Circulation, Vol 76, 1364-1372, Copyright © 1987 by American Heart Association
JR Kaplan, SB Manuck, MR Adams, KW Weingand and TB Clarkson
We studied the effect of propranolol on the diet-induced coronary artery
atherosclerosis (CAA) in 30 adult male cynomolgus monkeys living in social
groupings of five animals each. Animals in the "treated" segment (n = 15)
consumed propranolol, which was mixed into an atherogenic diet. Animals in
the "untreated" group (n = 15) consumed only the atherogenic diet. Finally,
the social groupings were subjected to disruption through monthly
redistribution of monkeys among the groups within each treatment segment.
The experiment lasted 26 months, following which all animals underwent
autopsy during which the coronary arteries were evaluated for
atherosclerosis. Regarding atherosclerosis, we observed a significant
interaction between social status and experimental condition (p less than
.03). Socially dominant animals had (as in previous studies) significantly
exacerbated CAA, but only in the untreated segment; the effect of social
dominance on CAA was abolished by long-term administration of propranolol.
The antiatherogenic effect of propranolol on dominant animals was
independent of the influences of serum lipid concentrations, blood
pressure, and resting heart rate. We conclude that treatment with
beta-adrenergic-blocking agents may confer a degree of protection against
CAA among individuals behaviorally predisposed to coronary heart disease.
ARTICLES
Inhibition of coronary atherosclerosis by propranolol in behaviorally predisposed monkeys fed an atherogenic diet
Department of Comparative Medicine, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, NC.
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