Circulation, Vol 77, 491-498, Copyright © 1988 by American Heart Association
RD Okada, D Glover, T Gaffney and S Williams
To study the potential usefulness of technetium-99m hexakis-2-methoxy-2-
methylpropyl-isonitrile (Tc-MIBI) as a cardiac perfusion imaging agent, the
left circumflex coronary arteries of 12 dogs were partially occluded. Eight
additional control dogs had no coronary artery stenosis. Myocardial Tc-MIBI
activities in the left circumflex and left anterior descending zones were
continuously monitored by miniature implantable radiation detectors for 4
hr after administration of the isotope. The dogs were then killed. Serial
gamma camera images were also acquired during the study. Heart rate,
arterial blood pressure, pressure distal to the stenosis, and cardiac
output did not change significantly during the experiment.
Microsphere-determined regional myocardial blood flow was significantly
reduced in the left circumflex distribution in the 12 dogs with coronary
artery stenoses. In the 12 dogs with left circumflex coronary artery
stenoses, the 4 hr fractional Tc-MIBI clearances from the normal and
ischemic zones were minimal and equivalent (0.15 +/- 0.05 vs 0.15 +/-
0.07). In the eight control dogs, 4 hr fractional Tc-MIBI clearances from
the left anterior descending and left circumflex artery zones were minimal
and equivalent (0.11 +/- 0.06 vs 0.10 +/- 0.07). Four hour fractional
Tc-MIBI clearance from the blood was 0.98 +/- 0.03 for the dogs with
stenosis and 0.97 +/- 0.02 for the dogs without stenosis. One additional
dog had complete occlusion of the left circumflex coronary artery followed
by administration of Tc-MIBI and scandium-46-labeled microspheres. This
heart was immediately sectioned and counted to determine the relationship
of regional blood flow to Tc-MIBI distribution (r = .92).(ABSTRACT
TRUNCATED AT 250 WORDS)
ARTICLES
Myocardial kinetics of technetium-99m-hexakis-2-methoxy-2-methylpropyl- isonitrile
St. Francis Medical Research Institute, Tulsa, OK 74136.
This article has been cited by other articles:
 |
|
 |
|
  P. Misra, D. Lebeche, H. Ly, M. Schwarzkopf, G. Diaz, R. J. Hajjar, A. D. Schecter, and J. V. Frangioni Quantitation of CXCR4 Expression in Myocardial Infarction Using 99mTc-Labeled SDF-1{alpha} J. Nucl. Med., June 1, 2008; 49(6): 963 - 969. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Madar, H. T. Ravert, Y. Du, J. Hilton, L. Volokh, R. F. Dannals, J. J. Frost, and J. M. Hare Characterization of Uptake of the New PET Imaging Compound 18F-Fluorobenzyl Triphenyl Phosphonium in Dog Myocardium J. Nucl. Med., August 1, 2006; 47(8): 1359 - 1366. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Natanzon, A. H. Aletras, L.-Y. Hsu, and A. E. Arai Determining Canine Myocardial Area at Risk with Manganese-enhanced MR Imaging Radiology, September 1, 2005; 236(3): 859 - 866. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Ibrahim, S. G. Nekolla, M. Hornke, H. P. Bulow, J. Dirschinger, A. Schomig, and M. Schwaiger Quantitative measurement of infarct size by contrast-enhanced magnetic resonance imaging early after acute myocardial infarction: Comparison with single-photon emission tomography using Tc99m-sestamibi J. Am. Coll. Cardiol., February 15, 2005; 45(4): 544 - 552. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Hatada, L. M. Riou, M. Ruiz, Y. Yamamichi, A. Duatti, R. L. Lima, A. R. Goode, D. D. Watson, G. A. Beller, and D. K. Glover 99mTc-N-DBODC5, a New Myocardial Perfusion Imaging Agent with Rapid Liver Clearance: Comparison with 99mTc-Sestamibi and 99mTc-Tetrofosmin in Rats J. Nucl. Med., December 1, 2004; 45(12): 2095 - 2101. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. B. Fram, R. R. Azar, A. W. Ahlberg, L. D. Gillam, J. F. Mitchel, F. J. Kiernan, J. A. Hirst, J. F. Mather, E. Ficaro, G. Cyr, et al. Duration of abnormal SPECT myocardial perfusion imaging following resolution of acute ischemia: an angioplasty model J. Am. Coll. Cardiol., February 5, 2003; 41(3): 452 - 459. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. M. Schaefer, B. Nowak, H.-J. Kaiser, K.-C. Koch, S. Block, J. vom Dahl, and U. Buell Comparison of Microsphere-Equivalent Blood Flow (15O-Water PET) and Relative Perfusion (99mTc-Tetrofosmin SPECT) in Myocardium Showing Metabolism-Perfusion Mismatch J. Nucl. Med., January 1, 2003; 44(1): 33 - 39. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Paluszkiewicz, P. Kwinecki, M. Jemielity, A. Szyszka, W. Dyszkiewicz, and A. Cieslinski Myocardial perfusion correlates with improvement of systolic function of the left ventricle after CABG. Dobutamine echocardiography and Tc-99m-MIBI SPECT study Eur. J. Cardiothorac. Surg., January 1, 2002; 21(1): 32 - 35. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Taki, S. Fujino, K. Nakajima, I. Matsunari, H. Okazaki, T. Saga, H. Bunko, and N. Tonami 99mTc-Sestamibi Retention Characteristics During Pharmacologic Hyperemia in Human Myocardium: Comparison with Coronary Flow Reserve Measured by Doppler Flowire J. Nucl. Med., October 1, 2001; 42(10): 1457 - 1463. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Soman, R. Taillefer, E. G. DePuey, J. E. Udelson, and A. Lahiri Enhanced detection of reversible perfusion defects by Tc-99m sestamibi compared to Tc-99m tetrofosmin during vasodilator stress SPECT imaging in mild-to-moderate coronary artery disease J. Am. Coll. Cardiol., February 1, 2001; 37(2): 458 - 462. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. G. Danias Stress testing and electron beam computed tomography for evaluation of patients with suspected coronary artery disease J. Am. Coll. Cardiol., January 1, 2001; 37(1): 334 - 335. [Full Text] [PDF]
|
|
|
|
|
|
B. Lubiszewska, E. Gosiewska, P. Hoffman, A. Teresinska, J. Rozanski, W. Piotrowski, W. Rydlewska-Sadowska, K. Kubicka, and W. Ruzyllo Myocardial perfusion and function of the systemic right ventricle in patients after atrial switch procedure for complete transposition: long-term follow-up J. Am. Coll. Cardiol., October 1, 2000; 36(4): 1365 - 1370. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Schomig, A. Kastrati, J. Dirschinger, J. Mehilli, U. Schricke, J. Pache, S. Martinoff, F.-J. Neumann, M. Schwaiger, and The Stent versus Thrombolysis for Occluded Coronar Coronary Stenting plus Platelet Glycoprotein IIb/IIIa Blockade Compared with Tissue Plasminogen Activator in Acute Myocardial Infarction N. Engl. J. Med., August 10, 2000; 343(6): 385 - 391. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Barilla, G. De Vincentis, E. Mangieri, M. Ciavolella, G. Pannitteri, F. Scopinaro, G. Critelli, and P. P. Campa Recovery of contractility of viable myocardium during inotropic stimulation is not dependent on an increase of myocardial blood flow in the absence of collateral filling J. Am. Coll. Cardiol., March 1, 1999; 33(3): 697 - 704. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. A. Dakik, J. F. Howell, G. M. Lawrie, R. Espada, D. G. Weilbaecher, Z.-X. He, J. J. Mahmarian, and M. S. Verani Assessment of Myocardial Viability With 99mTc-Sestamibi Tomography Before Coronary Bypass Graft Surgery : Correlation With Histopathology and Postoperative Improvement in Cardiac Function Circulation, November 4, 1997; 96(9): 2892 - 2898. [Abstract] [Full Text]
|
|
|
|
|
|
G. Ambrosio, S. Betocchi, L. Pace, M. A. Losi, P. Perrone-Filardi, A. Soricelli, F. Piscione, J. Taube, F. Squame, M. Salvatore, et al. Prolonged Impairment of Regional Contractile Function After Resolution of Exercise-Induced Angina: Evidence of Myocardial Stunning in Patients With Coronary Artery Disease Circulation, November 15, 1996; 94(10): 2455 - 2464. [Abstract] [Full Text]
|
|
|
|
|
|
R. Medrano, R. W. Lowry, J. B. Young, D. G. Weilbaecher, L. H. Michael, I. Afridi, Z.-X. He, J. J. Mahmarian, and M. S. Verani Assessment of Myocardial Viability With 99mTc Sestamibi in Patients Undergoing Cardiac Transplantation: A Scintigraphic/Pathological Study Circulation, September 1, 1996; 94(5): 1010 - 1017. [Abstract] [Full Text]
|
|
|
|
|
|
G. L. Schaer, L. J. Spaccavento, K. F. Browne, K. A. Krueger, D. Krichbaum, J. M. Phelan, W. O. Fletcher, C. L. Grines, S. Edwards, M. K. Jolly, et al. Beneficial Effects of RheothRx Injection in Patients Receiving Thrombolytic Therapy for Acute Myocardial Infarction: Results of a Randomized, Double-Blind, Placebo-Controlled Trial Circulation, August 1, 1996; 94(3): 298 - 307. [Abstract] [Full Text]
|
|
|
|
|
|
V. Sansoy, D. K. Glover, D. D. Watson, M. Ruiz, W. H. Smith, J. P. Simanis, and G. A. Beller Comparison of Thallium-201 Resting Redistribution With Technetium-99m–Sestamibi Uptake and Functional Response to Dobutamine for Assessment of Myocardial Viability Circulation, August 15, 1995; 92(4): 994 - 1004. [Abstract] [Full Text]
|
|
|
|
|
|
T. D. Miller, T. F. Christian, M. R. Hopfenspirger, D. O. Hodge, B. J. Gersh, and R. J. Gibbons Infarct Size After Acute Myocardial Infarction Measured by Quantitative Tomographic 99mTc Sestamibi Imaging Predicts Subsequent Mortality Circulation, August 1, 1995; 92(3): 334 - 341. [Abstract] [Full Text]
|
|
|
|
|
|
D. K. Glover, M. Ruiz, N. C. Edwards, M. Cunningham, J. P. Simanis, W. H. Smith, D. D. Watson, and G. A. Beller Comparison Between 201Tl and 99mTc Sestamibi Uptake During Adenosine-Induced Vasodilation as a Function of Coronary Stenosis Severity Circulation, February 1, 1995; 91(3): 813 - 820. [Abstract] [Full Text]
|
|
|
|
|
|
R. J. Gibbons, D. R. Holmes, G. S. Reeder, K. R. Bailey, M. R. Hopfenspirger, B. J. Gersh, and The Mayo Coronary Care Unit and Catheterization La Immediate Angioplasty Compared with the Administration of a Thrombolytic Agent Followed by Conservative Treatment for Myocardial Infarction N. Engl. J. Med., March 11, 1993; 328(10): 685 - 691. [Abstract] [Full Text]
|
|
|
|
 |
|
 T. F. Christian, I. P. Clements, T. Behrenbeck, K. C. Huber, J. H. Chesebro, B. J. Gersh, and R. J. Gibbons Limitations of the Electrocardiogram in Estimating Infarction Size after Acute Reperfusion Therapy for Myocardial Infarction Ann Intern Med, February 15, 1991; 114(4): 264 - 270. [Abstract] [PDF]
|
|