Circulation, Vol 78, 1-9, Copyright © 1988 by American Heart Association
H Yasue, A Takizawa, M Nagao, S Nishida, M Horie, J Kubota, S Omote, K Takaoka and K Okumura
Two hundred forty-five patients with variant angina were followed for an
average of 80.5 months (range, 36-184 months). Survival rate at 1, 3, 5,
and 10 years was 98%, 97%, 97%, and 93%, respectively. Survival rate
without myocardial infarction at 1, 3, 5, and 10 years was 86%, 85%, 83%,
and 81%, respectively. By univarite analysis, ST segment elevation in both
the anterior and inferior electrocardiographic leads was the most important
factor influencing survival, followed by use of calcium antagonists, left
ventricular function, smoking, and alcohol intake. The variables that
significantly correlated with survival without myocardial infarction were
use of calcium antagonists, left ventricular function, extent and severity
of coronary artery disease, coronary artery bypass surgery, and disease
activity. Multivariate analysis using the Cox proportional hazards model
showed that intake of calcium antagonists, extent and severity of coronary
artery disease, and ST segment elevation in both the anterior and inferior
leads were significant independent predictors of survival without
myocardial infarction. We conclude that long-term prognosis for patients
with variant angina is relatively good and that use of calcium antagonists
improves it.
ARTICLES
Long-term prognosis for patients with variant angina and influential factors
Division of Cardiology, Kumamoto University Medical School, Japan.
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