This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Wilcken, D. E. Articles by Hickey, A. J. Search for Related Content PubMed PubMed Citation Articles by Wilcken, D. E. Articles by Hickey, A. J.

Circulation, Vol 78, 10-14, Copyright © 1988 by American Heart Association

ARTICLES

Lifetime risk for patients with mitral valve prolapse of developing severe valve regurgitation requiring surgery

DE Wilcken and AJ Hickey
Department of Cardiovascular Medicine, University of New South Wales, Prince Henry Hospital, Sydney, Australia.

Severe mitral regurgitation requiring surgery is the most common life- threatening complication of mitral valve prolapse (MVP) and is due to progressive myxomatous change in the valve. We identified all residents of New South Wales, Australia, who had mitral valve surgery for myxomatous valve disease during 1982 and, using these data and the adult population statistics from 1982, estimated the cumulative risk of valve surgery in patients with MVP. In 1982, 50 of the 5.36 million New South Wales residents required surgery for this complication of MVP. Of the 50, 36 were men and 14 were women, which was significantly different from the population sex distribution (p less than 0.02) for mean age +/- SD of 60 +/- 11 years (range, 26-78 years). Using our previously determined 4% prevalence of adult MVP in New South Wales, we estimated the number of male and female patients with MVP at risk for each 5-year age interval and calculated age-specific event rates. The results show that the cumulative risk is minimal below the age of 50 years but then rises steeply, particularly in men. The risks in men aged 50, 60, and 70 years (with 95% confidence intervals) were 1:202 (130-448), 1:53 (37-82), and 1:28 (22-41), respectively. In women, the risk was less than half that in men (p less than 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)

This article has been cited by other articles:

				A. M. Gillinov, E. H. Blackstone, A. Alaulaqi, J. F. Sabik III, T. Mihaljevic, L. G. Svensson, P. L. Houghtaling, A. Salemi, D. R. Johnston, and B. W. Lytle Outcomes After Repair of the Anterior Mitral Leaflet for Degenerative Disease Ann. Thorac. Surg., September 1, 2008; 86(3): 708 - 717. [Abstract] [Full Text] [PDF]

				H. Gunduz, H. Arinc, M. Kayardi, R. Akdemir, S. Ozyildirim, and C. Uyan Heart rate turbulence and heart rate variability in patients with mitral valve prolapse Europace, July 1, 2006; 8(7): 515 - 520. [Abstract] [Full Text] [PDF]

				C. Kaymaz, N. Ozdemir, and M. Ozkan Differentiating clinical and echocardiographic characteristics of chordal rupture detected in patients with rheumatic mitral valve disease and floppy mitral valve: impact of the infective endocarditis on chordal rupture Eur J Echocardiogr, March 1, 2005; 6(2): 117 - 126. [Abstract] [Full Text] [PDF]

				K. J. Grande-Allen, B. P. Griffin, N. B. Ratliff, D. M. Cosgrove III, and I. Vesely Glycosaminoglycan profiles of myxomatous mitral leaflets and chordae parallel the severity of mechanical alterations J. Am. Coll. Cardiol., July 16, 2003; 42(2): 271 - 277. [Abstract] [Full Text] [PDF]

				L. A. Freed, E. J. Benjamin, D. Levy, M. G. Larson, J. C. Evans, D. L. Fuller, B. Lehman, and R. A. Levine Mitral valve prolapse in the general population: the benign nature of echocardiographic features in the Framingham Heart Study J. Am. Coll. Cardiol., October 2, 2002; 40(7): 1298 - 1304. [Abstract] [Full Text] [PDF]

				M. S. J. Sutton and A. E. Weyman Mitral Valve Prolapse Prevalence and Complications: An Ongoing Dialogue Circulation, September 10, 2002; 106(11): 1305 - 1307. [Full Text] [PDF]

				L. A. Freed, D. Levy, R. A. Levine, M. G. Larson, J. C. Evans, D. L. Fuller, B. Lehman, and E. J. Benjamin Prevalence and Clinical Outcome of Mitral-Valve Prolapse N. Engl. J. Med., July 1, 1999; 341(1): 1 - 7. [Abstract] [Full Text] [PDF]

				A. J. Orencia, G. W. Petty, B. K. Khandheria, J. F. Annegers, D. J. Ballard, J. D. Sicks, W. M. O'Fallon, and J. P. Whisnant Risk of Stroke With Mitral Valve Prolapse in Population-Based Cohort Study Stroke, January 1, 1995; 26(1): 7 - 13. [Abstract] [Full Text]

				L. H. Cohn, G. S. Couper, S. F. Aranki, R. J. Rizzo, N. M. Kinchla, and J. J. Collins Jr. Long-term results of mitral valve reconstruction for regurgitation of the myxomatous mitral valve J. Thorac. Cardiovasc. Surg., January 1, 1994; 107(1): 143 - 151. [Abstract] [Full Text]

				R. B. Devereux, R. Kramer-Fox, and P. Kligfield Mitral Valve Prolapse: Causes, Clinical Manifestations, and Management Ann Intern Med, August 15, 1989; 111(4): 305 - 317. [Abstract] [PDF]