Circulation, Vol 78, 104-115, Copyright © 1988 by American Heart Association
H Iida, I Kanno, A Takahashi, S Miura, M Murakami, K Takahashi, Y Ono, F Shishido, A Inugami and N Tomura
An in vivo technique was developed for measuring the absolute myocardial
blood flow with H215O and dynamic positron-emission tomography. This
technique was based on a new model involving the concept of the tissue
fraction, which was defined as the fraction of the tissue mass in the
volume of the region of interest. The myocardium was imaged dynamically by
positron-emission tomography, starting at the time of intravenous bolus
injection of H215O. The arterial input function was measured continuously
with a beta-ray detector. A separate image after C15O inhalation was also
obtained for correction of the H215O radioactivity in the blood. The
absolute myocardial blood flow and the tissue fraction were calculated for
15 subjects with a kinetic technique under region-of-interest analysis.
These results seem consistent with their coronary angiographic findings.
The mean value of the measured absolute myocardial blood flows in normal
subjects was 0.95 +/- 0.09 ml/min/g. This technique detected a diffuse
decrease of myocardial blood flow in patients with triple-vessel disease.
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Measurement of absolute myocardial blood flow with H215O and dynamic positron-emission tomography. Strategy for quantification in relation to the partial-volume effect [published erratum appears in Circulation 1988 Oct;78(4):1078]
Department of Radiology and Nuclear Medicine, Research Institute for Brain and Blood Vessels-AKITA, Japan.
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