Circulation, Vol 78, 132-141, Copyright © 1988 by American Heart Association
SD Colan, E Trowitzsch, G Wernovsky, GF Sholler, SP Sanders and AR Castaneda
Left ventricular dimensions, wall thickness, wall stress, and indexes of
afterload, preload, contractility, and early diastolic function, as well as
regional wall motion, were determined by echocardiographic methods in
patients with transposition of the great vessels after arterial switch
operation and in age-matched normal controls. In patients evaluated early
after surgery, body surface area-adjusted left ventricular dimensions were
smaller, and wall thickness was increased compared with controls.
Ventricular performance (fractional shortening) was normal in most patients
but was abnormally low in 10%. Nevertheless, contractility was normal or
augmented in all subjects, with a mean value higher than the control group.
The reduction in systolic function was related to altered loading
conditions with a combination of reduced afterload and preload combined
with augmented contractility. These altered myocardial mechanics appeared
to be secondary to routine therapy with digitalis and diuretics. Diastolic
function was also normal with differences in the rate of peak filling and
rate of wall thinning entirely attributable to differences in ventricular
size and function, and normalized indexes of diastolic function were not
different between patients and controls. Patients evaluated late after
repair were found to have normal regional wall motion with no evidence to
suggest regional dysfunction as might be seen with regional ischemia.
Ventricular size, wall thickness, systolic function, afterload, preload,
contractility, and early diastolic function were indistinguishable from
control values. Indexes of diastolic function demonstrated the same
relation to age, body surface area, and ventricular size and function in
both patients and controls.(ABSTRACT TRUNCATED AT 250 WORDS)
ARTICLES
Myocardial performance after arterial switch operation for transposition of the great arteries with intact ventricular septum
Department of Cardiology, Children's Hospital, Boston, MA 02143.
This article has been cited by other articles:
 |
|
 |
|
  Y.-H. Choi, D. B. Cowan, A. M. Moran, S. D. Colan, C. Stamm, K. Takeuchi, I. Friehs, P. J. del Nido, and F. X. McGowan Jr. Myocyte apoptosis occurs early during the development of pressure-overload hypertrophy in infant myocardium. J. Thorac. Cardiovasc. Surg., June 1, 2009; 137(6): 1356 - 1362.e3. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Lamers, G. Ensing, R. Pignatelli, C. Goldberg, L. Bezold, N. Ayres, and R. Gajarski Evaluation of Left Ventricular Systolic Function in Pediatric Sickle Cell Anemia Patients Using the End-Systolic Wall Stress-Velocity of Circumferential Fiber Shortening Relationship J. Am. Coll. Cardiol., June 6, 2006; 47(11): 2283 - 2288. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. G Raja, A. Shauq, and M. Kaarne Outcomes after Arterial Switch Operation for Simple Transposition Asian Cardiovasc Thorac Ann, June 1, 2005; 13(2): 190 - 198. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L Hui, A K T Chau, M P Leung, C S W Chiu, and Y F Cheung Assessment of left ventricular function long term after arterial switch operation for transposition of the great arteries by dobutamine stress echocardiography Heart, January 1, 2005; 91(1): 68 - 72. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G Bosi, R Crepaz, M R Gamberini, M Fortini, S Scarcia, E Bonsante, W Pitscheider, and M Vaccari Left ventricular remodelling, and systolic and diastolic function in young adults with {beta} thalassaemia major: a Doppler echocardiographic assessment and correlation with haematological data Heart, July 1, 2003; 89(7): 762 - 766. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S M Tibby and I A Murdoch Monitoring cardiac function in intensive care Arch. Dis. Child., January 1, 2003; 88(1): 46 - 52. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Vaccari, R. Crepaz, M. Fortini, M. R. Gamberini, S. Scarcia, W. Pitscheider, and G. Bosi Left Ventricular Remodeling, Systolic Function, and Diastolic Function in Young Adults With {beta}-Thalassemia Intermedia : A Doppler Echocardiography Study Chest, February 1, 2002; 121(2): 506 - 512. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Myers Transposition of the Great Arteries Ann. Thorac. Surg., March 1, 1997; 63(3): 895 - 898. [Full Text]
|
|
|
|
 |
|
 G. Wernovsky, D. Wypij, R. A. Jonas, J. E. Mayer Jr, F. L. Hanley, P. R. Hickey, A. Z. Walsh, A. C. Chang, A. R. Castaneda, J. W. Newburger, et al. Postoperative Course and Hemodynamic Profile After the Arterial Switch Operation in Neonates and Infants : A Comparison of Low-Flow Cardiopulmonary Bypass and Circulatory Arrest Circulation, October 15, 1995; 92(8): 2226 - 2235. [Abstract] [Full Text]
|
|
|
|
|
|
G. Wernovsky, J. E. Mayer Jr., R. A. Jonas, F. L. Hanley, E. H. Blackstone, J. W. Kirklin, and A. R. Castaneda Factors influencing early and late outcome of the arterial switch operation for transposition of the great arteries J. Thorac. Cardiovasc. Surg., February 1, 1995; 109(2): 289 - 302. [Abstract] [Full Text]
|
|
|
|
|
|
S. D. Colan, C. Boutin, A. R. Castaneda, and G. Wernovsky Status of the left ventricle after arterial switch operation for transposition of the great arteriesHemodynamic and echocardiographic evaluation J. Thorac. Cardiovasc. Surg., February 1, 1995; 109(2): 311 - 321. [Abstract] [Full Text]
|
|