Circulation, Vol 78, 539-545, Copyright © 1988 by American Heart Association
E Barrett-Connor and KT Khaw
Plasma obtained and frozen in 1972-1974 from 1,009 white men (40-79 years
old) who have been followed for 12 years was examined for endogenous sex
hormone levels according to prevalent or subsequent cardiovascular disease.
In these older men, no sex hormone measured (testosterone, androstenedione,
estrone, or estradiol) was significantly associated with known
cardiovascular disease at baseline or with subsequent cardiovascular
mortality or ischemic heart disease morbidity or mortality. Sex
hormone-binding globulin levels were also similar by disease status.
Analyses of hormone:sex hormone-binding globulin ratios or of
estrogen:androgen ratios showed a similar lack of association with
cardiovascular disease. Testosterone levels were significantly inversely
associated with levels of blood pressure, fasting plasma glucose, and
triglyceride and body mass index. In contrast, the only significant
estrogen risk factor associations were positive correlations of estrone
with total plasma cholesterol, triglyceride, and glucose. These data do not
support a causal role for elevated endogenous estrogen levels and heart
disease.
ARTICLES
Endogenous sex hormones and cardiovascular disease in men. A prospective population-based study
University of California, San Diego, Department of Community and Family Medicine, La Jolla 92093.
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