This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Walsh, M. N. Articles by Geltman, E. M. Search for Related Content PubMed PubMed Citation Articles by Walsh, M. N. Articles by Geltman, E. M.

Circulation, Vol 78, 612-620, Copyright © 1988 by American Heart Association

ARTICLES

Delineation of impaired regional myocardial perfusion by positron emission tomography with H2(15)O

MN Walsh, SR Bergmann, RL Steele, JL Kenzora, MM Ter-Pogossian, BE Sobel and EM Geltman
Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110.

Positron emission tomography with 15O-labeled water (H2(15)O) can be used to delineate abnormal regional myocardial blood flow in experimental animals. To determine the feasibility of this method in humans, we studied 33 subjects (9 normal volunteers and 24 patients with angiographically documented coronary artery disease) at rest and after myocardial hyperemia induced with intravenous infusion of dipyridamole. At rest, the myocardial region demonstrating the lowest relative H2(15)O activity exhibited 71 +/- 8% of activity in the region with peak activity in control subjects and 62 +/- 17% in patients (p = NS). After the dipyridamole infusion, differences between the two groups were accentuated. In control subjects, activity in the region with lowest relative radioactivity averaged 77 +/- 5% of that in the region with peak activity. In patients, it averaged 55 +/- 22% of activity in the region with peak activity (p less than 0.01). Results in patients with ischemia with or without a history of remote myocardial infarction were not significantly different. In 22 of the 24 patients, the region with lowest relative perfusion corresponded anatomically to the region of myocardium distal to a stenosis. Thus, delineation of regional myocardial perfusion in patients with coronary artery disease is possible with positron emission tomography and H2(15)O. Further studies will be necessary to prospectively determine sensitivity and specificity.

This article has been cited by other articles:

				V. C. Vasile, L. Babuin, E. Giannitsis, H. A. Katus, and A. S. Jaffe Relationship of MRI-Determined Infarct Size and cTnI Measurements in Patients with ST-Elevation Myocardial Infarction Clin. Chem., March 1, 2008; 54(3): 617 - 619. [Full Text] [PDF]

				C. Katoh, K. Morita, T. Shiga, N. Kubo, K. Nakada, and N. Tamaki Improvement of Algorithm for Quantification of Regional Myocardial Blood Flow Using 15O-Water with PET J. Nucl. Med., November 1, 2004; 45(11): 1908 - 1916. [Abstract] [Full Text] [PDF]

				R M Quinlivan, R O Robinson, and M N Maisey Positron emission tomography in paediatric cardiology Arch. Dis. Child., December 1, 1998; 79(6): 520 - 522. [Full Text]

				B. L. Zaret and F. J. Wackers Nuclear Cardiology- Second of Two Parts N. Engl. J. Med., September 16, 1993; 329(12): 855 - 863. [Full Text]