Circulation, Vol 78, 1365-1372, Copyright © 1988 by American Heart Association
JA Vassallo, DM Cassidy, KE Kindwall, FE Marchlinski and ME Josephson
The purpose of this study was to determine left ventricular activation,
dispersion of refractoriness, and total recovery time in patients with
coronary artery disease and ventricular tachycardia and in patients with
the long QT syndrome and to compare these patients with a group of normal
patients. Left ventricular endocardial catheter mapping and left
ventricular refractory period determination were performed in 18 patients.
Group 1 consisted of seven patients with no heart disease and no
arrhythmia; group 2 consisted of six patients with previous infarction and
sustained ventricular tachycardia; and group 3 consisted of five patients
with prolonged QT interval and previous cardiac arrest. Total left
ventricular endocardial activation was significantly longer in group 2 (75
+/- 23 msec, mean +/- SD) compared with group 1 (34 +/- 9 msec, p less than
0.01) and group 3 (42 +/- 5 msec, p less than 0.05). Dispersion of
refractoriness was significantly greater in group 3 (87 +/- 27 msec) than
in group 1 (40 +/- 14 msec, p less than 0.01) and group 2 (53 +/- 14 msec,
p less than 0.05). Dispersion of total recovery time was significantly
greater in group 2 (90 +/- 30 msec) than in group 1 (52 +/- 14 msec, p less
than 0.05) as well as group 3 (114 +/- 43 msec) compared with group 1 (p
less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
ARTICLES
Nonuniform recovery of excitability in the left ventricle
Clinical Electrophysiology Laboratory, Hospital of the University of Pennsylvania, Philadelphia 19104.
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