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(Circulation. 1953;8:15.)
© 1953 American Heart Association, Inc.

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The Syndrome of Patent Ductus Arteriosus with Pulmonary Hypertension

HERBERT HULTGREN M.D.¹; ARTHUR SELZER M.D.¹; ANN PURDY M.D.¹; EMILE HOLMAN M.D.¹; FRANK GERBODE M.D.¹

¹ From the Departments of Medicine, Pediatrics and Surgery of the Stanford University School of Medicine, San Francisco, Calif.

Eight cases of patent ductus arteriosus associated with marked pulmonary hypertension are presented with complete cardiac catheterization studies in six patients and autopsy studies in three cases. Four patients had clear evidence of a "reversed" shunt through the ductus, three presenting the clinical picture of cyanotic congenital heart disease. The authors discuss the nature of the increased resistance of the pulmonary vascular bed which is the basis of the circulatory changes in these cases.

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