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(Circulation. 1953;8:494.)
© 1953 American Heart Association, Inc.

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Antibiotic Therapy of Bacterial Endocarditis

IV. Successful Short-Term (Two Weeks) Combined Penicillin-Dihydrostreptomycin Therapy in Subacute Bacterial Endocarditis Caused by Penicillin-Sensitive Streptococci

JOSEPH E. GERACI M.D. WILLIAM J. MARTIN M.D.

Twenty-three patients with endocarditis caused by penicillin-sensitive streptococci have received short-term treatment with penicillin and dihydrostreptomycin, combined, for two weeks. Five of the patients died from complications of their infection; 18 were living and well, at the time of this study, after an average follow-up period of more than one year. No failures in treatment or relapses have occurred. It is concluded from the study of these patients that 1,000,000 units of aqueous procaine penicillin-G and 1 Gm. of dihydrostreptomycin sulfate given intramuscularly every 12 hours for two weeks is curative for this type of endocarditis.

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