Circulation, Vol 80, 1-9, Copyright © 1989 by American Heart Association
PM Vanhoutte and H Shimokawa
The endothelium releases the powerful vasodilator and antiaggregatory
substance, EDRF, both under basal conditions and upon stimulation by a wide
variety of agents. Endothelial injury or dysfunction may play an important
role in the spasmogenicity of the coronary artery, although other possible
alterations related to atherosclerosis should also be considered. Among the
possible stimuli, aggregating platelets are important as a source of
vasoconstrictor substances. The endothelium may also produce the vasoactive
substances EDHF and EDCF(s). Their pathophysiologic significance remains to
be determined.
ARTICLES
Endothelium-derived relaxing factor and coronary vasospasm
Department of Physiology and Biophysics, Mayo Clinic, Rochester, MN 55905.
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