Circulation, Vol 80, 146-157, Copyright © 1989 by American Heart Association
GE Billman and RS Hoskins
Periodic fluctuations in the R-R interval have been used as noninvasive
measures of cardiac autonomic tone. For example, a reduced heart rate
variability has been shown to correlate with an increased mortality in
patients recovering from myocardial infarction. The effects that
physiologic perturbations such as exercise have on this heart rate
variability have not been investigated. Therefore, heart rate variability
was measured throughout a submaximal exercise test in 36 mongrel dogs with
healed anterior myocardial infarctions. The amplitude of the respiratory
component (0.24-1.04 Hz) was determined by time- series analysis techniques
and was used as an index of cardiac vagal tone. On a subsequent day, a
2-minute coronary occlusion was initiated during the last minute of
exercise. Twenty-two animals developed ventricular fibrillation
(susceptible), whereas 14 animals did not (resistant). Exercise elicited a
significantly greater increase in heart rate (resistant, 205.4 +/- 7.1;
susceptible, 227.0 +/- 5.4 beats/min) in susceptible animals, which was
accompanied by a greater reduction in the cardiac vagal tone index
(resistant, 2.7 +/- 0.3; susceptible, 1.1 +/- 0.2 ln msec2) as compared
with resistant animals. Conversely, atropine sulfate (50 micrograms/kg)
given during exercise elicited a greater heart rate increase in the
resistant dogs (heart rate change: resistant, 54.2 +/- 7.0; susceptible,
18.7 +/- 4.4 beats/min). Taken together, these data suggest that exercise
elicited a greater reduction in cardiac vagal tone in animals known to be
susceptible to ventricular fibrillation.
ARTICLES
Time-series analysis of heart rate variability during submaximal exercise. Evidence for reduced cardiac vagal tone in animals susceptible to ventricular fibrillation
Department of Physiology, Ohio State University, Columbus 43210.
This article has been cited by other articles:
 |
|
 |
|
  G. E. Billman Cardiac autonomic neural remodeling and susceptibility to sudden cardiac death: effect of endurance exercise training Am J Physiol Heart Circ Physiol, October 1, 2009; 297(4): H1171 - H1193. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. K. Lahiri, P. J. Kannankeril, and J. J. Goldberger Assessment of Autonomic Function in Cardiovascular Disease: Physiological Basis and Prognostic Implications J. Am. Coll. Cardiol., May 6, 2008; 51(18): 1725 - 1733. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K P Savonen, T A Lakka, J A Laukkanen, T H Rauramaa, J T Salonen, and R Rauramaa Workload at the heart rate of 100 beats/min and mortality in middle-aged men with known or suspected coronary heart disease Heart, April 1, 2008; 94(4): e14 - e14. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. E. Billman Heart rate response to onset of exercise: evidence for enhanced cardiac sympathetic activity in animals susceptible to ventricular fibrillation Am J Physiol Heart Circ Physiol, July 1, 2006; 291(1): H429 - H435. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Goldberger, F. K. Le, M. Lahiri, P. J. Kannankeril, J. Ng, and A. H. Kadish Assessment of parasympathetic reactivation after exercise Am J Physiol Heart Circ Physiol, June 1, 2006; 290(6): H2446 - H2452. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kukielka, D. R. Seals, and G. E. Billman Cardiac vagal modulation of heart rate during prolonged submaximal exercise in animals with healed myocardial infarctions: effects of training Am J Physiol Heart Circ Physiol, April 1, 2006; 290(4): H1680 - H1685. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. E. Billman and M. Kukielka Effects of endurance exercise training on heart rate variability and susceptibility to sudden cardiac death: protection is not due to enhanced cardiac vagal regulation J Appl Physiol, March 1, 2006; 100(3): 896 - 906. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. L. Smith, M. Kukielka, and G. E. Billman Heart rate recovery after exercise: a predictor of ventricular fibrillation susceptibility after myocardial infarction Am J Physiol Heart Circ Physiol, April 1, 2005; 288(4): H1763 - H1769. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. E. Billman Aerobic exercise conditioning: a nonpharmacological antiarrhythmic intervention J Appl Physiol, February 1, 2002; 92(2): 446 - 454. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. S. Khan, N. Zhao, A. L. Sica, N. Gootman, and P. M. Gootman Changes in R-R and Q-T Intervals Following Cardiac Vagotomy in Neonatal Swine Experimental Biology and Medicine, January 1, 2001; 226(1): 32 - 36. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. W. Hughes and C. M. Stoney Depressed Mood Is Related to High-Frequency Heart Rate Variability During Stressors Psychosom Med, December 1, 2000; 62(6): 796 - 803. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. N. Bartels, J. M. Gonzalez, W. Kim, and R. E. De Meersman Oxygen Supplementation and Cardiac-Autonomic Modulation in COPD Chest, September 1, 2000; 118(3): 691 - 696. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Houle and G. E. Billman Low-frequency component of the heart rate variability spectrum: a poor marker of sympathetic activity Am J Physiol Heart Circ Physiol, January 1, 1999; 276(1): H215 - H223. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Shusterman, B. Aysin, V. Gottipaty, R. Weiss, S. Brode, D. Schwartzman, K. P. Anderson, and for the ESVEM Investigators Autonomic nervous system activity and the spontaneous initiation of ventricular tachycardia J. Am. Coll. Cardiol., December 1, 1998; 32(7): 1891 - 1899. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. Tulppo, T. H. Makikallio, T. Seppanen, R. T. Laukkanen, and H. V. Huikuri Vagal modulation of heart rate during exercise: effects of age and physical fitness Am J Physiol Heart Circ Physiol, February 1, 1998; 274(2): H424 - H429. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-F. Xiao and J. P. Morgan Cocaine Blockade of the Acetylcholine-Activated Muscarinic K+ Channel in Ferret Cardiac Myocytes J. Pharmacol. Exp. Ther., January 1, 1998; 284(1): 10 - 18. [Abstract] [Full Text]
|
|
|
|
 |
|
 B. Diamond, H Kim, J DeLuca, and D. Cordero Cardiovascular regulation in multiple sclerosis Multiple Sclerosis, November 1, 1995; 1(3): 156 - 162. [Abstract] [PDF]
|
|
|
|
 |
|
 M. J. Cowan Measurement of Heart Rate Variability West J Nurs Res, February 1, 1995; 17(1): 32 - 48. [Abstract] [PDF]
|
|
|
|
|
|
P. J. Kannankeril and J. J. Goldberger Parasympathetic effects on cardiac electrophysiology during exercise and recovery Am J Physiol Heart Circ Physiol, June 1, 2002; 282(6): H2091 - H2098. [Abstract] [Full Text] [PDF]
|
|