Circulation, Vol 81, 107-117, Copyright © 1990 by American Heart Association
G de Simone, RB Devereux, S Chien, MH Alderman, SA Atlas and JH Laragh
Although increased blood viscosity occurs in several cardiovascular
diseases, little is known of factors influencing blood rheology in normal
adults. Accordingly, we examined the relations of whole blood viscosity
(WBV) to its rheologic determinants (hematocrit level, plasma viscosity,
protein concentration, and red cell aggregability and rigidity), to
demographic and laboratory variables, and to cardiovascular risk factors in
128 normotensive employed adults. Hematocrit levels accounted for 67-84% of
variability of WBV at shear rates from 208 to 0.1 sec-1 with lesser
contributions from plasma viscosity, red cell aggregability, and rigidity
(multiple r = 0.95- 0.97); WBV was predicted accurately from standard
measurements of hematocrit and total plasma protein levels (multiple r =
0.78-0.92 in "learning" and "test" analysis). Male sex, obesity, dietary
Na+ intake, and increasing age had additive effects on WBV (multiple r
greater than or equal to 0.59, p less than 0.00001); the last three of
these factors and black race independently predicted plasma viscosity
(multiple r = 0.36, p less than 0.001). Among regulators of plasma volume,
plasma renin activity and urinary Na+ excretion bore independent positive
relations to WBV. Diastolic and mean blood pressures were independent
predictors of WBV and hematocrit levels (all p less than 0.05).
Conventional risk factors (e.g., triglycerides, obesity, and cholesterol
levels) were positively related to WBV or plasma viscosity. Thus, in
apparently normal adults, 1) WBV or plasma viscosity are increased by male
sex, obesity, high sodium intake, aging, and black race, 2) WBV is
positively related to plasma renin activity, 3) WBV or plasma viscosity are
related to diastolic and mean blood pressures, triglycerides and
cholesterol concentrations, and 4) WBV can be predicted from simple
measurements of hematocrit and total plasma protein levels.
ARTICLES
Relation of blood viscosity to demographic and physiologic variables and to cardiovascular risk factors in apparently normal adults
Department of Medicine, New York Hospital-Cornell Medical Center, New York 10021.
This article has been cited by other articles:
 |
|
 |
|
  G. de Simone, R. B. Devereux, M. Chinali, L. G. Best, E. T. Lee, T. K. Welty, and for the Strong Heart Study Investigators Association of Blood Pressure With Blood Viscosity in American Indians: The Strong Heart Study Hypertension, April 1, 2005; 45(4): 625 - 630. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Sass, C. Blanquart, P.-E. Morange, M. Pfister, and S. Visvikis-Siest Association Between Factor VII Polymorphisms and Blood Pressure: The Stanislas Cohort Hypertension, November 1, 2004; 44(5): 674 - 680. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Dammers, F. Stifft, J. H. M. Tordoir, J. M. M. Hameleers, A. P. G. Hoeks, and P. J. E. H. M. Kitslaar Shear stress depends on vascular territory: comparison between common carotid and brachial artery J Appl Physiol, February 1, 2003; 94(2): 485 - 489. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Chan, S. F. Knutsen, G. G. Blix, J. W. Lee, and G. E. Fraser Water, Other Fluids, and Fatal Coronary Heart Disease: The Adventist Health Study Am. J. Epidemiol., May 1, 2002; 155(9): 827 - 833. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Palmieri, A. Celentano, M. J. Roman, G. de Simone, M. R. Lewis, L. Best, E. T. Lee, D. C. Robbins, B. V. Howard, and R. B. Devereux Fibrinogen and Preclinical Echocardiographic Target Organ Damage: The Strong Heart Study Hypertension, November 1, 2001; 38(5): 1068 - 1074. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Palmieri, G. de Simone, M. J. Roman, J. E. Schwartz, T. G. Pickering, and R. B. Devereux Ambulatory Blood Pressure and M;etabolic Abnormalities in Hypertensive Subjects With Inappropriately High Left Ventricular Mass Hypertension, November 1, 1999; 34(5): 1032 - 1040. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Arabi, B. J. Morgan, B. Goodman, D. S. Puleo, A. Xie, and J. B. Skatrud Daytime blood pressure elevation after nocturnal hypoxia J Appl Physiol, August 1, 1999; 87(2): 689 - 698. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.K. Samijo, J.M. Willigers, R. Barkhuysen, P.J.E.H.M. Kitslaar, R.S. Reneman, P.J. Brands, and A.P.G. Hoeks Wall shear stress in the human common carotid artery as function of age and gender Cardiovasc Res, August 1, 1998; 39(2): 515 - 522. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Junker, J. Heinrich, H. Ulbrich, H. Schulte, R. Schonfeld, E. Kohler, and G. Assmann Relationship Between Plasma Viscosity and the Severity of Coronary Heart Disease Arterioscler. Thromb. Vasc. Biol., June 1, 1998; 18(6): 870 - 875. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Gardin, A. Arnold, J. S. Gottdiener, N. D. Wong, L. P. Fried, H. S. Klopfenstein, D. H. O'Leary, R. Tracy, and R. Kronmal Left Ventricular Mass in the Elderly : The Cardiovascular Health Study Hypertension, May 1, 1997; 29(5): 1095 - 1103. [Abstract] [Full Text]
|
|
|
|
 |
|
 D. S. Sharp, J. D. Curb, I. J. Schatz, H. J. Meiselman, T. C. Fisher, C. M. Burchfiel, B. L. Rodriguez, and K. Yano Mean Red Cell Volume as a Correlate of Blood Pressure Circulation, May 1, 1996; 93(9): 1677 - 1684. [Abstract] [Full Text]
|
|
|
|
|
|
M. H. Alderman, S. Madhavan, H. Cohen, J. E. Sealey, and J. H. Laragh Low Urinary Sodium Is Associated With Greater Risk of Myocardial Infarction Among Treated Hypertensive Men Hypertension, June 1, 1995; 25(6): 1144 - 1152. [Abstract] [Full Text]
|
|
|
|
 |
|
 J.P. Fawcett and D.B. Menkes Does Cholesterol Depletion Have Adverse Effects on Blood Rheology? Angiology, March 1, 1994; 45(3): 199 - 206. [Abstract] [PDF]
|
|
|
|
 |
|
 E. I. Cabrera Fischer, R. L. Armentano, F. M. Pessana, S. Graf, L. Romero, A. I. Christen, A. Simon, and J. Levenson Endothelium-dependent arterial wall tone elasticity modulated by blood viscosity Am J Physiol Heart Circ Physiol, February 1, 2002; 282(2): H389 - H394. [Abstract] [Full Text] [PDF]
|
|