Circulation, Vol 81, 201-211, Copyright © 1990 by American Heart Association
R Ferrari, O Alfieri, S Curello, C Ceconi, A Cargnoni, P Marzollo, A Pardini, E Caradonna and O Visioli
We have investigated the relation between occurrence of myocardial
oxidative stress and functional recovery during postischemic reperfusion in
20 selected patients subjected to aortocoronary bypass grafting. Patients
were selected for having normal percent ejection fraction and left
ventricular end-diastolic pressure before the operation. Occurrence of
oxidative stress was assessed by measuring the formation and release of
oxidized glutathione (GSSG) in the coronary sinus immediately before aortic
cross-clamp, 1, 5, 10, and 20 minutes after removal of aortic cross-clamp,
and 10 and 20 minutes after the end of cardiopulmonary bypass. Reduced
glutathione (GSH), lactate, and creatine phosphokinase release were also
monitored with the same timing. Standard hemodynamic measurements were
recorded by means of a triple-lumen thermodilution pulmonary artery
catheter before sternotomy, 15 minutes after the end of cardiopulmonary
bypass, and during the 24 hours after termination of cardiopulmonary
bypass. Reperfusion in patients after a short period of ischemia (less than
30 minutes; group 1) resulted in a small and transient release in the
coronary sinus of GSSG and GSH and in a progressive improvement of
hemodynamic parameters reaching a stable state 4 hours after the operation.
In patients with a period of ischemia longer than 30 minutes (group 2),
reperfusion induced a marked and sustained release of lactate, GSH, and
GSSG; the arteriocoronary sinus difference for GSSG was still negative
after the end of cardiopulmonary bypass. The arteriocoronary sinus
difference for creatine phosphokinase also remained negative for as long as
20 minutes after cardiopulmonary bypass, and the rate of functional
recovery was significantly delayed, reaching the values of group 1 only 12
hours after the operation. In these patients there was a positive
correlation (r = 0.88, p less than 0.01) between the duration of ischemia
and the myocardial arteriovenous difference for GSSG. In addition, there
was a negative correlation between the arteriocoronary sinus difference for
GSSG and cardiac index measured 2, 4, and 6 hours after the operation.
These data suggest for the first time that, depending on the severity of
the ischemic period, oxidative stress occurs during reperfusion of patients
with coronary artery disease who are subjected to heart surgery and that it
may be linked with a delay in postoperative recovery of cardiac function.
ARTICLES
Occurrence of oxidative stress during reperfusion of the human heart
Cattedra di Cardiologia, University of Brescia, Italy.
This article has been cited by other articles:
 |
|
 |
|
  T. Seefeldt, Y. Zhao, W. Chen, A. S. Raza, L. Carlson, J. Herman, A. Stoebner, S. Hanson, R. Foll, and X. Guan Characterization of a Novel Dithiocarbamate Glutathione Reductase Inhibitor and Its Use as a Tool to Modulate Intracellular Glutathione J. Biol. Chem., January 30, 2009; 284(5): 2729 - 2737. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Moukdar, J. Robidoux, O. Lyght, J. Pi, K. W. Daniel, and S. Collins Reduced antioxidant capacity and diet-induced atherosclerosis in uncoupling protein-2-deficient mice J. Lipid Res., January 1, 2009; 50(1): 59 - 70. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Z. Simkhovich, M. T. Kleinman, and R. A. Kloner Air Pollution and Cardiovascular Injury: Epidemiology, Toxicology, and Mechanisms J. Am. Coll. Cardiol., August 26, 2008; 52(9): 719 - 726. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J C Ferreira, E L Gastal, and O J Ginther Uterine blood flow and perfusion in mares with uterine cysts: effect of the size of the cystic area and age Reproduction, April 1, 2008; 135(4): 541 - 550. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. M. Hadzimichalis, S. S. Baliga, R. Golfetti, K. M. Jaques, B. L. Firestein, and G. F. Merrill Acetaminophen-mediated cardioprotection via inhibition of the mitochondrial permeability transition pore-induced apoptotic pathway Am J Physiol Heart Circ Physiol, December 1, 2007; 293(6): H3348 - H3355. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Ramlawi, H. Otu, S. Mieno, M. Boodhwani, N. R. Sodha, R. T. Clements, C. Bianchi, and F. W. Sellke Oxidative Stress and Atrial Fibrillation After Cardiac Surgery: A Case-Control Study Ann. Thorac. Surg., October 1, 2007; 84(4): 1166 - 1173. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Milei, P. Forcada, C. G. Fraga, D. R. Grana, G. Iannelli, M. Chiariello, I. Tritto, and G. Ambrosio Relationship between oxidative stress, lipid peroxidation, and ultrastructural damage in patients with coronary artery disease undergoing cardioplegic arrest/reperfusion Cardiovasc Res, March 1, 2007; 73(4): 710 - 719. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Zweier and M.A. H. Talukder The role of oxidants and free radicals in reperfusion injury Cardiovasc Res, May 1, 2006; 70(2): 181 - 190. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Suleiman, D. Aronson, R. Asleh, M. R. Kapeliovich, A. Roguin, S. R. Meisel, M. Shochat, A. Sulieman, S. A. Reisner, W. Markiewicz, et al. Haptoglobin Polymorphism Predicts 30-Day Mortality and Heart Failure in Patients With Diabetes and Acute Myocardial Infarction Diabetes, September 1, 2005; 54(9): 2802 - 2806. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. R. Paiva, R. Novo, B. B. Matsubara, L. S. Matsubara, P. S. Azevedo, M. F. Minicucci, A. O. Campana, and L. A. M. Zornoff {beta}-Carotene Attenuates the Paradoxical Effect of Tobacco Smoke on the Mortality of Rats after Experimental Myocardial Infarction J. Nutr., September 1, 2005; 135(9): 2109 - 2113. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. M. Knott, M.-G. Ryou, J. Sun, A. Heymann, A. B. Sharma, Y. Lei, M. Baig, R. T. Mallet, and A. H. Olivencia-Yurvati Pyruvate-fortified cardioplegia suppresses oxidative stress and enhances phosphorylation potential of arrested myocardium Am J Physiol Heart Circ Physiol, September 1, 2005; 289(3): H1123 - H1130. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. M. Lalu, E. Pasini, C. J. Schulze, M. Ferrari-Vivaldi, G. Ferrari-Vivaldi, T. Bachetti, and R. Schulz Ischaemia-reperfusion injury activates matrix metalloproteinases in the human heart Eur. Heart J., January 1, 2005; 26(1): 27 - 35. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Valgimigli, E. Merli, P. Malagutti, O. Soukhomovskaia, G. Cicchitelli, A. Antelli, D. Canistro, G. Francolini, G. Macri, F. Mastrorilli, et al. Hydroxyl radical generation, levels of tumor necrosis factor-alpha, and progression to heart failure after acute myocardial infarction J. Am. Coll. Cardiol., June 2, 2004; 43(11): 2000 - 2008. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Lassnigg, A. Punz, R. Barker, P. Keznickl, N. Manhart, E. Roth, and M. Hiesmayr Influence of intravenous vitamin E supplementation in cardiac surgery on oxidative stress: a double-blinded, randomized, controlled study Br. J. Anaesth., February 1, 2003; 90(2): 148 - 154. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Ceconi, G. La Canna, O. Alfieri, A. Cargnoni, G. Coletti, S. Curello, M. Zogno, G. Parrinello, S. H. Rahimtoola, and R. Ferrari Revascularization of hibernating myocardium. Rate of metabolic and functional recovery and occurrence of oxidative stress Eur. Heart J., December 1, 2002; 23(23): 1877 - 1885. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Stangl, G. Baumann, K. Stangl, and S. B Felix Negative inotropic mediators released from the heart after myocardial ischaemia-reperfusion Cardiovasc Res, January 1, 2002; 53(1): 12 - 30. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z.-k. Wu, M. R. Tarkka, J. Eloranta, E. Pehkonen, L. Kaukinen, E. L. Honkonen, and S. Kaukinen Effect of Ischemic Preconditioning on Myocardial Protection in Coronary Artery Bypass Graft Patients : Can the Free Radicals Act as a Trigger for Ischemic Preconditioning? Chest, April 1, 2001; 119(4): 1061 - 1068. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Cargnoni, C. Ceconi, P. Bernocchi, A. Boraso, G. Parrinello, S. Curello, and R. Ferrari Reduction of oxidative stress by carvedilol: role in maintenance of ischaemic myocardium viability Cardiovasc Res, August 18, 2000; 47(3): 556 - 566. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Ceconi, P. Bernocchi, A. Boraso, A. Cargnoni, P. Pepi, S. Curello, and R. Ferrari New insights on myocardial pyridine nucleotides and thiol redox state in ischemia and reperfusion damage Cardiovasc Res, August 18, 2000; 47(3): 586 - 594. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G LaCanna, S.H Rahimtoola, O Visioli, R Giubbini, O Alfieri, M Zognio, E Milan, C Ceconi, M Gargano, R LoRusso, et al. Sensitivity, specificity, and predictive accuracies of non-invasive tests, singly and in combination, for diagnosis of hibernating myocardium Eur. Heart J., August 2, 2000; 21(16): 1358 - 1367. [Abstract] [PDF]
|
|
|
|
 |
|
 F. Courtois, I. Suc, C. Garofalo, M. Ledoux, E. Seidman, and E. Levy Iron-ascorbate alters the efficiency of Caco-2 cells to assemble and secrete lipoproteins Am J Physiol Gastrointest Liver Physiol, July 1, 2000; 279(1): G12 - G19. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Buffon, S. A. Santini, V. Ramazzotti, S. Rigattieri, G. Liuzzo, L. M. Biasucci, F. Crea, B. Giardina, and A. Maseri Large, sustained cardiac lipid peroxidation and reduced antioxidant capacity in the coronary circulation after brief episodes of myocardial ischemia J. Am. Coll. Cardiol., March 1, 2000; 35(3): 633 - 639. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Morrison, D. W. Jacobsen, D. L. Sprecher, K. Robinson, P. Khoury, and S. R. Daniels Serum Glutathione in Adolescent Males Predicts Parental Coronary Heart Disease Circulation, November 30, 1999; 100(22): 2244 - 2247. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Massoudy, S. Zahler, A. Barankay, B. F. Becker, J. A. Richter, and H. Meisner Sodium nitroprusside during coronary artery bypass grafting: evidence for an antiinflammatory action Ann. Thorac. Surg., April 1, 1999; 67(4): 1059 - 1064. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T W Koh, J Hooper, M Kemp, F D Ferdinand, D G Gibson, and J R Pepper Intraoperative release of troponin T in coronary venous and arterial blood and its relation to recovery of left ventricular function and oxidative metabolism following coronary artery surgery Heart, October 1, 1998; 80(4): 341 - 348. [Abstract] [Full Text]
|
|
|
|
|
|
D. J Duncker, R. Schulz, R. Ferrari, D. Garcia-Dorado, C. Guarnieri, G. Heusch, and P. D Verdouw "Myocardial stunning": remaining questions Cardiovasc Res, June 1, 1998; 38(3): 549 - 558. [Full Text] [PDF]
|
|
|
|
|
|
N. Hayashida, T. Isomura, T. Sato, H. Maruyama, T. Higashi, K. Arinaga, and S. Aoyagi Minimally Diluted Tepid Blood Cardioplegia Ann. Thorac. Surg., March 1, 1998; 65(3): 615 - 621. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D P JENKINS Are patients with poor left ventricular function more prone to oxidative stress during cardiac surgery? Heart, March 1, 1998; 79(3): 219 - 219. [Full Text]
|
|
|
|
|
|
E De Vecchi, M G Pala, G Di Credico, V Agape, G Paolini, P A Bonini, A Grossi, and R Paroni Relation between left ventricular function and oxidative stress in patients undergoing bypass surgery Heart, March 1, 1998; 79(3): 242 - 247. [Abstract] [Full Text]
|
|
|
|
|
|
M. P. Reilly, N. Delanty, L. Roy, J. Rokach, P. O. Callaghan, P. Crean, J. A. Lawson, and G. A. FitzGerald Increased Formation of the Isoprostanes IPF2{alpha}-I and 8-Epi-Prostaglandin F2{alpha} in Acute Coronary Angioplasty : Evidence for Oxidant Stress During Coronary Reperfusion in Humans Circulation, November 18, 1997; 96(10): 3314 - 3320. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. Westhuyzen, A. D. Cochrane, P. J. Tesar, T. Mau, D. B. Cross, M. P. Frenneaux, F. A. Khafagi, and S. J. Fleming EFFECT OF PREOPERATIVE SUPPLEMENTATION WITH {{alpha}}-TOCOPHEROL AND ASCORBIC ACID ON MYOCARDIAL INJURY IN PATIENTS UNDERGOING CARDIAC OPERATIONS J. Thorac. Cardiovasc. Surg., May 1, 1997; 113(5): 942 - 948. [Abstract] [Full Text]
|
|
|
|
|
|
R. Ferrari, A. Cargnoni, P. Bernocchi, E. Pasini, S. Curello, C. Ceconi, and T.J.C. Ruigrok Metabolic Adaptation During a Sequence of No-Flow and Low-Flow Ischemia: A Possible Trigger for Hibernation Circulation, November 15, 1996; 94(10): 2587 - 2596. [Abstract] [Full Text]
|
|
|
|
|
|
L. Torracca, E. Pasini, S. Curello, C. Ceconi, G. Coletti, O. Alfieri, R. Solfrini, and R. Ferrari Continuous Versus Intermittent Warm Blood Cardioplegia: Functional and Energetics Changes Ann. Thorac. Surg., October 1, 1996; 62(4): 1172 - 1179. [Abstract] [Full Text]
|
|
|
|
|
|
S. R. Powell, L. Aiuto, D. Hall, and A. J. Tortolani ZINC SUPPLEMENTATION ENHANCES THE EFFECTIVENESS OF ST. THOMAS' HOSPITAL NO. 2 CARDIOPLEGIC SOLUTION IN AN IN VITRO MODEL OF HYPOTHERMIC CARDIAC ARREST J. Thorac. Cardiovasc. Surg., December 1, 1995; 110(6): 1642 - 1648. [Abstract] [Full Text]
|
|
|
|
|
|
M. A. Arstall, J. Yang, I. Stafford, W. H. Betts, and J. D. Horowitz N-Acetylcysteine in Combination With Nitroglycerin and Streptokinase for the Treatment of Evolving Acute Myocardial Infarction : Safety and Biochemical Effects Circulation, November 15, 1995; 92(10): 2855 - 2862. [Abstract] [Full Text]
|
|
|
|
|
|
A. Mezzetti, A. M. Calafiore, D. Lapenna, R. Deslauriers, G. Tian, T. A. Salerno, A. M. Verna, G. Bosco, S. D. Pierdomenico, and F. Caccurullo Intermittent antegrade warm cardioplegia reduces oxidative stress and improves metabolism of the ischemic-reperfused human myocardium J. Thorac. Cardiovasc. Surg., April 1, 1995; 109(4): 787 - 795. [Abstract] [Full Text]
|
|
|
|
 |
|
 Shu Tao, G. Calza, F. Lerzo, A. Virgone, N. Camassa, G. Panizzon, L. Brunelli, R. Moretti, P. Grasso, G. Ghiggeri, et al. Activation of the intracellular glutathione system by oxydative stress during cardiopulmonary bypass and myocardial perfusion Perfusion, January 1, 1995; 10(1): 45 - 50. [Abstract] [PDF]
|
|
|
|
|
|
G. Valen, G. A Khoschsorur, S. M Almdahl, H. Esterbauer, and J. Vaage Lipid peroxidation in open-heart surgery Perfusion, July 1, 1994; 9(4): 277 - 283. [Abstract] [PDF]
|
|
|
|
|
|
H. J. Toivonen and M. Ahotupa Free radical reaction products and antioxidant capacity in arterial plasma during coronary artery bypass grafting J. Thorac. Cardiovasc. Surg., July 1, 1994; 108(1): 140 - 147. [Abstract] [Full Text]
|
|
|
|
|
|
J. G. Coghlan, W. D. Flitter, S. M. Clutton, R. Panda, R. Daly, G. Wright, C. D. Ilsley, and T. F. Slater Allopurinol pretreatment improves postoperative recovery and reduces lipid peroxidation in patients undergoing coronary artery bypass grafting J. Thorac. Cardiovasc. Surg., January 1, 1994; 107(1): 248 - 256. [Abstract] [Full Text]
|
|