Circulation, Vol 81, 238-246, Copyright © 1990 by American Heart Association
R Karam, BP Healy and P Wicker
After a myocardial infarction (MI), the remaining myocardium undergoes a
compensatory reactive hypertrophy. Although coronary perfusion to the
surviving myocardium can be an important determinant of cardiac function in
this setting, there are no available data regarding myocardial blood flow
in reactive hypertrophy. Accordingly, we measured coronary blood flow and
reserve using radioactive microspheres in rats 4 weeks after induction of
an MI by ligation of the left coronary artery. Maximal coronary dilation
was induced by Carbochrome, a potent coronary vasodilator, infused at a
rate of 0.45 mg/kg/min up to a total dose of 12 mg/kg. Sham-operated rats
served as controls. All animals in the infarct group had a large MI
affecting 30-51% (average, 41%) of the left ventricle. Left ventricular
end-diastolic pressure was significantly elevated (30 +/- 6.5 vs. 8.0 +/-
2.5 mm Hg in sham- operated rats, p less than 0.01) and baseline
hemodynamic indexes of cardiac performance were significantly (p less than
0.01) reduced in this group. Myocyte cross-sectional area measurements were
used as an index to quantify the degree of reactive hypertrophy and
indicated that the infarcted animals had, on average, a 30% hypertrophic
response of the surviving left ventricular myocardium. In the infarcted
animals, both coronary flow and vasodilator reserve in the surviving
myocardium were depressed. Maximal coronary blood flow in the remaining
myocardium was significantly lower than that measured in the sham-operated
animals (839 and 1,479 ml/min/100 g, respectively; p less than 0.001).
Similarly, minimal coronary resistance was significantly higher in the MI
group as compared with the sham group (0.12 vs. 0.07 mm Hg/ml/min/100 g,
respectively; p less than 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)
ARTICLES
Coronary reserve is depressed in postmyocardial infarction reactive cardiac hypertrophy
Research Institute, Cleveland Clinic Foundation, Ohio.
This article has been cited by other articles:
 |
|
 |
|
  D. Leosco, G. Rengo, G. Iaccarino, L. Golino, M. Marchese, F. Fortunato, C. Zincarelli, E. Sanzari, M. Ciccarelli, G. Galasso, et al. Exercise promotes angiogenesis and improves {beta}-adrenergic receptor signalling in the post-ischaemic failing rat heart Cardiovasc Res, May 1, 2008; 78(2): 385 - 394. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. I. Dedkov, W. Zheng, L. P. Christensen, R. M. Weiss, F. Mahlberg-Gaudin, and R. J. Tomanek Preservation of coronary reserve by ivabradine-induced reduction in heart rate in infarcted rats is associated with decrease in perivascular collagen Am J Physiol Heart Circ Physiol, July 1, 2007; 293(1): H590 - H598. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Merkus, D. B. Haitsma, O. Sorop, F. Boomsma, V. J. de Beer, J. M. J. Lamers, P. D. Verdouw, and D. J. Duncker Coronary vasoconstrictor influence of angiotensin II is reduced in remodeled myocardium after myocardial infarction Am J Physiol Heart Circ Physiol, November 1, 2006; 291(5): H2082 - H2089. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. I. Dedkov, W. Zheng, and R. J. Tomanek Compensatory growth of coronary arterioles in postinfarcted heart: regional differences in DNA synthesis and growth factor/receptor expression patterns Am J Physiol Heart Circ Physiol, October 1, 2006; 291(4): H1686 - H1693. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Leri, J. Kajstura, and P. Anversa Cardiac Stem Cells and Mechanisms of Myocardial Regeneration Physiol Rev, October 1, 2005; 85(4): 1373 - 1416. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. I. Dedkov, L. P. Christensen, R. M. Weiss, and R. J. Tomanek Reduction of heart rate by chronic {beta}1-adrenoceptor blockade promotes growth of arterioles and preserves coronary perfusion reserve in postinfarcted heart Am J Physiol Heart Circ Physiol, June 1, 2005; 288(6): H2684 - H2693. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Merkus, B. Houweling, M. van Vliet, and D. J. Duncker Contribution of KATP+ channels to coronary vasomotor tone regulation is enhanced in exercising swine with a recent myocardial infarction Am J Physiol Heart Circ Physiol, March 1, 2005; 288(3): H1306 - H1313. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Merkus, B. Houweling, A. H. van den Meiracker, F. Boomsma, and D. J. Duncker Contribution of endothelin to coronary vasomotor tone is abolished after myocardial infarction Am J Physiol Heart Circ Physiol, February 1, 2005; 288(2): H871 - H880. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Lei, R. Zhou, W. Zheng, L. P. Christensen, R. M. Weiss, and R. J. Tomanek Bradycardia Induces Angiogenesis, Increases Coronary Reserve, and Preserves Function of the Postinfarcted Heart Circulation, August 17, 2004; 110(7): 796 - 802. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Zheng, R. M. Weiss, X. Wang, R. Zhou, A. M. Arlen, L. Lei, E. Lazartigues, and R. J. Tomanek DITPA stimulates arteriolar growth and modifies myocardial postinfarction remodeling Am J Physiol Heart Circ Physiol, May 1, 2004; 286(5): H1994 - H2000. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Nahrendorf, K.-H. Hiller, D. Theisen, K. Hu, C. Waller, R. Kaiser, A. Haase, G. Ertl, R. Brinkmann, and W. R. Bauer Effect of Transmyocardial Laser Revascularization on Myocardial Perfusion and Left Ventricular Remodeling after Myocardial Infarction in Rats Radiology, November 1, 2002; 225(2): 487 - 493. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. I. Jugdutt, V. Menon, D. Kumar, and H. Idikio Vascular remodeling during healing after myocardial infarction in the dog model: Effects of reperfusion, amlodipine and enalapril J. Am. Coll. Cardiol., May 1, 2002; 39(9): 1538 - 1545. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. B Haitsma, D. Bac, N. Raja, F. Boomsma, P. D Verdouw, and D. J Duncker Minimal impairment of myocardial blood flow responses to exercise in the remodeled left ventricle early after myocardial infarction, despite significant hemodynamic and neurohumoral alterations Cardiovasc Res, December 1, 2001; 52(3): 417 - 428. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Waller, K.-H. Hiller, E. Kahler, K. Hu, M. Nahrendorf, S. Voll, A. Haase, G. Ertl, and W. R. Bauer Serial Magnetic Resonance Imaging of Microvascular Remodeling in the Infarcted Rat Heart Circulation, March 20, 2001; 103(11): 1564 - 1569. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Quinones, B. H. Greenberg, H. A. Kopelen, C. Koilpillai, M. C. Limacher, D. M. Shindler, B. J. Shelton, D. H. Weiner, and for the SOLVD Investigators Echocardiographic predictors of clinical outcome in patients with left ventricular dysfunction enrolled in the SOLVD registry and trials: significance of left ventricular hypertrophy J. Am. Coll. Cardiol., April 1, 2000; 35(5): 1237 - 1244. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Wildhirt, H. Suzuki, D. Horstman, S. Weismuller, R. R. Dudek, K. Akiyama, and B. Reichart Selective Modulation of Inducible Nitric Oxide Synthase Isozyme in Myocardial Infarction Circulation, September 2, 1997; 96(5): 1616 - 1623. [Abstract] [Full Text]
|
|
|
|
|
|
K. C. Wollert, R. Studer, K. Doerfer, E. Schieffer, C. Holubarsch, H. Just, and H. Drexler Differential Effects of Kinins on Cardiomyocyte Hypertrophy and Interstitial Collagen Matrix in the Surviving Myocardium After Myocardial Infarction in the Rat Circulation, April 1, 1997; 95(7): 1910 - 1917. [Abstract] [Full Text]
|
|
|
|
|
|
C. M. Kramer, W. J. Rogers, T. M. Theobald, T. P. Power, S. Petruolo, and N. Reichek Remote Noninfarcted Region Dysfunction Soon After First Anterior Myocardial Infarction: A Magnetic Resonance Tagging Study Circulation, August 15, 1996; 94(4): 660 - 666. [Abstract] [Full Text]
|
|
|
|
|
|
H.J. M. G. Nelissen-Vrancken, J. J.M. Debets, L. H.E.H. Snoeckx, M. J.A.P. Daemen, and J. F.M. Smits Time-Related Normalization of Maximal Coronary Flow in Isolated Perfused Hearts of Rats With Myocardial Infarction Circulation, January 15, 1996; 93(2): 349 - 355. [Abstract] [Full Text]
|
|
|
|
|
|
J. Zhang and K. M. McDonald Bioenergetic Consequences of Left Ventricular Remodeling Circulation, August 15, 1995; 92(4): 1011 - 1019. [Abstract] [Full Text]
|
|
|
|
 |
|
 N. G. Uren, T. Crake, D. C. Lefroy, R. de Silva, G. J. Davies, and A. Maseri Reduced Coronary Vasodilator Function in Infarcted and Normal Myocardium after Myocardial Infarction N. Engl. J. Med., July 28, 1994; 331(4): 222 - 227. [Abstract] [Full Text]
|
|