Circulation, Vol 81, 281-288, Copyright © 1990 by American Heart Association
CW Haws and RL Lux
Classic cable theory was used to analyze the relation between the
activation-recovery interval measured from unipolar electrograms and
transmembrane action potential duration. Theoretic analysis demonstrated
that the temporal derivative of the extracellular potential is proportional
to a spatial weighting of the third temporal derivative of the
transmembrane action potentials along a cable with uniform propagation in a
homogeneous medium. Thus, the activation- recovery interval, measured as
the interval between times of minimum derivative (Vmin) of the QRS and
maximum derivative (Vmax) of the T wave, should be related to action
potential duration, measured as the interval between times of Vmax of the
upstroke and Vmin of the downstroke of the transmembrane action potential.
This relation was examined experimentally in 12 anesthetized dogs. Unipolar
electrograms and transmembrane action potentials were recorded
simultaneously from sites within 2 mm of each other during control states,
cardiac sympathetic nerve stimulation, localized epicardial warming, and
graded reductions in myocardial perfusion. The heart was paced from several
sites. There was close correlation between activation-recovery interval and
action potential duration measurements taken during cardiac sympathetic
nerve stimulation and local epicardial warming (r = 0.96 and 0.99 for
cardiac sympathetic nerve stimulation and warming, respectively). In five
animals in which coronary perfusion pressure was gradually lowered, the
variables correlated closely over a range of values from 62 to 212 msec (r
= 0.98). However, although the overall correlation was good and mean
differences between activation-recovery interval and action potential
duration were small, in individual cases there were differences up to 24
msec.(ABSTRACT TRUNCATED AT 250 WORDS)
ARTICLES
Correlation between in vivo transmembrane action potential durations and activation-recovery intervals from electrograms. Effects of interventions that alter repolarization time
Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City 84112.
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