Circulation, Vol 81, 470-476, Copyright © 1990 by American Heart Association
DH Blankenhorn, P Alaupovic, E Wickham, HP Chin and SP Azen
A within-group risk factor analysis was conducted to predict angiographic
change in the Cholesterol Lowering Atherosclerosis Study, a randomized,
placebo-controlled trial of colestipol plus niacin therapy in men with
previous coronary bypass surgery. Global angiographic change, including
both native coronary arteries and bypass grafts after 2 treatment years,
was the end point. Risk factors included on-trial clinical measures, plasma
lipids, lipoproteins, and apolipoproteins. Univariate analysis indicated
that risk factors previously observed by others in epidemiologic
investigation of ischemic heart disease--total cholesterol, LDL
cholesterol, non-HDL cholesterol, triglycerides, apolipoprotein B, and
diastolic blood pressure--had significant effects in the placebo-treated
group. Univariate analysis indicated significant effects of apolipoprotein
C- III in drug- and placebo-treated groups. Multivariate analysis indicated
the predominant risk factor predicting the probability of global coronary
progression was non-HDL cholesterol in placebo-treated subjects and the
content of apolipoprotein C-III in high density lipoproteins of
drug-treated subjects. Both drug- and placebo-treated group findings point
to an important role for triglyceride-rich lipoproteins in progression and
regression of human atherosclerosis.
ARTICLES
Prediction of angiographic change in native human coronary arteries and aortocoronary bypass grafts. Lipid and nonlipid factors
Department of Medicine and Preventive Medicine, University of Southern California, Los Angeles.
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