Donate Help Contact The AHA Sign In Home
American Heart Association
Circulation
Search: search_blue_button Advanced Search
Circulation. 1990;81:772-779

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Treasure, C. B.
Right arrow Articles by Alexander, R. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Treasure, C. B.
Right arrow Articles by Alexander, R. W.

Circulation, Vol 81, 772-779, Copyright © 1990 by American Heart Association


ARTICLES

Endothelium-dependent dilation of the coronary microvasculature is impaired in dilated cardiomyopathy

CB Treasure, JA Vita, DA Cox, RD Fish, JB Gordon, GH Mudge, WS Colucci, MG Sutton, AP Selwyn and RW Alexander
Department of Medicine (Cardiovascular Division), Brigham and Women's Hospital, Boston, MA 02115.

Dilator reserve of the coronary microvasculature is diminished in patients with dilated cardiomyopathy. Although increased extravascular compressive forces, tachycardia, and increased myocardial mass can explain some impairment, recent evidence suggests the possibility of intrinsic microvascular disease. We tested the hypothesis that impairment of endothelium-dependent dilation of the microvasculature could be a contributing mechanism. We infused the endothelium-dependent dilator acetylcholine (Ach) (10(-8) to 10(-6) M) and the smooth muscle vasodilator adenosine (AD) (10(-6) to 10(-4) M) into the left anterior descending coronary artery in eight patients with dilated cardiomyopathy (mean ejection fraction, 28%) and seven controls (atypical chest pain). Small vessel resistance was assessed by measuring coronary blood flow (CBF) at constant arterial pressure with a Doppler velocity catheter (corrected for cross-sectional area by angiography). With Ach, control patients increased CBF 232 +/- 40% (mean +/- SEM), whereas CBF did not significantly change in cardiomyopathy patients (41 +/- 24%) (p less than 0.0001, control vs. cardiomyopathy). With AD, control patients increased CBF 422 +/- 56% and cardiomyopathy patients increased CBF 268 +/- 43% (p = 0.13). An index of the proportion of coronary flow reserve attributable to endothelium-dependent vasodilation was obtained by standardizing each patient's Ach dose response to his maximal AD flow response. In seven control patients receiving both Ach and AD, 56 +/- 9% of the maximal AD flow response was attained with the endothelium-dependent vasodilator Ach, whereas in seven cardiomyopathy patients receiving both Ach and AD, only 23 +/- 14% of the maximal AD response was attained (p less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)


This article has been cited by other articles:


Home page
HypertensionHome page
A. Gamboa, C. Shibao, A. Diedrich, S. Y. Paranjape, G. Farley, B. Christman, S. R. Raj, D. Robertson, and I. Biaggioni
Excessive Nitric Oxide Function and Blood Pressure Regulation in Patients With Autonomic Failure
Hypertension, June 1, 2008; 51(6): 1531 - 1536.
[Abstract] [Full Text] [PDF]


Home page
HeartHome page
D. Neglia, R. De Maria, S. Masi, M. Gallopin, P. Pisani, S. Pardini, A. Gavazzi, A. L'Abbate, and O. Parodi
Effects of long-term treatment with carvedilol on myocardial blood flow in idiopathic dilated cardiomyopathy
Heart, July 1, 2007; 93(7): 808 - 813.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Heart Circ. Physiol.Home page
R. M. Gill, J. C. Braz, N. Jin, G. J. Etgen, and W. Shen
Restoration of impaired endothelium-dependent coronary vasodilation in failing heart: role of eNOS phosphorylation and CGMP/cGK-I signaling
Am J Physiol Heart Circ Physiol, June 1, 2007; 292(6): H2782 - H2790.
[Abstract] [Full Text] [PDF]


Home page
J Am Coll CardiolHome page
E. M. deGoma, R. H. Vagelos, M. B. Fowler, and E. A. Ashley
Emerging Therapies for the Management of Decompensated Heart Failure: From Bench to Bedside
J. Am. Coll. Cardiol., November 28, 2006; (2006) j.jacc.2006.08.039v1.
[Abstract] [Full Text] [PDF]


Home page
J CARDIOVASC PHARMACOL THERHome page
F. Bitar, A. Lerman, M. W. Akhter, P. Hatamizadeh, M. Janmohamed, S. Khan, and U. Elkayam
Variable response of conductance and resistance coronary arteries to endothelial stimulation in patients with heart failure due to nonischemic dilated cardiomyopathy.
Journal of Cardiovascular Pharmacology and Therapeutics, September 1, 2006; 11(3): 197 - 202.
[Abstract] [PDF]


Home page
RadiologyHome page
P. Knaapen, M. J. W. Gotte, W. J. Paulus, J. J. M. Zwanenburg, P. A. Dijkmans, R. Boellaard, J. T. Marcus, J. W. R. Twisk, C. A. Visser, A. C. van Rossum, et al.
Does Myocardial Fibrosis Hinder Contractile Function and Perfusion in Idiopathic Dilated Cardiomyopathy? PET and MR Imaging Study.
Radiology, August 1, 2006; 240(2): 380 - 388.
[Abstract] [Full Text] [PDF]


Home page
Cardiovasc ResHome page
P. van der Harst, A. A. Voors, W. H. van Gilst, M. Bohm, and D. J. van Veldhuisen
Statins in the treatment of chronic heart failure: Biological and clinical considerations
Cardiovasc Res, August 1, 2006; 71(3): 443 - 454.
[Abstract] [Full Text] [PDF]


Home page
Eur Heart JHome page
F. Rigo, S. Gherardi, M. Galderisi, L. Pratali, L. Cortigiani, R. Sicari, and E. Picano
The prognostic impact of coronary flow-reserve assessed by Doppler echocardiography in non-ischaemic dilated cardiomyopathy
Eur. Heart J., June 1, 2006; 27(11): 1319 - 1323.
[Abstract] [Full Text] [PDF]


Home page
J Am Board Fam MedHome page
R. P. Blankfield
Can Natriuretic Peptide Levels Predict the Cardiovascular Complications of COX-2 Inhibitors and Nonsteroidal Anti-inflammatory Drugs?
J Am Board Fam Med, March 1, 2006; 19(2): 178 - 182.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Heart Circ. Physiol.Home page
M. Azzawi and C. Austin
Extravascular pressure modulates responses of isolated rat coronary arteries to vasodilator, but not vasoconstrictor, stimuli
Am J Physiol Heart Circ Physiol, March 1, 2006; 290(3): H1151 - H1156.
[Abstract] [Full Text] [PDF]


Home page
Eur Heart JHome page
D. J. Green, A. J. Maiorana, J. H. J. Siong, V. Burke, M. Erickson, C. T. Minson, W. Bilsborough, and G. O'Driscoll
Impaired skin blood flow response to environmental heating in chronic heart failure
Eur. Heart J., February 1, 2006; 27(3): 338 - 343.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Heart Circ. Physiol.Home page
X. Sun and D. D. Ku
Selective right, but not left, coronary endothelial dysfunction precedes development of pulmonary hypertension and right heart hypertrophy in rats
Am J Physiol Heart Circ Physiol, February 1, 2006; 290(2): H758 - H764.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Heart Circ. Physiol.Home page
D. G. Haider, R. A. Bucek, A. G. Giurgea, G. Maurer, H. Glogar, E. Minar, M. Wolzt, M. R. Mehrabi, and M. Baghestanian
PGE1 analog alprostadil induces VEGF and eNOS expression in endothelial cells
Am J Physiol Heart Circ Physiol, November 1, 2005; 289(5): H2066 - H2072.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Heart Circ. Physiol.Home page
S. Iida, Y. Chu, J. Francis, R. M. Weiss, C. A. Gunnett, F. M. Faraci, and D. D. Heistad
Gene transfer of extracellular superoxide dismutase improves endothelial function in rats with heart failure
Am J Physiol Heart Circ Physiol, August 1, 2005; 289(2): H525 - H532.
[Abstract] [Full Text] [PDF]


Home page
Am J Crit CareHome page
K. B. Keller and L. Lemberg
Statin Therapy in Congestive Heart Failure
Am. J. Crit. Care., July 1, 2005; 14(4): 338 - 340.
[Full Text] [PDF]


Home page
Physiol. Rev.Home page
W. C. Stanley, F. A. Recchia, and G. D. Lopaschuk
Myocardial Substrate Metabolism in the Normal and Failing Heart
Physiol Rev, July 1, 2005; 85(3): 1093 - 1129.
[Abstract] [Full Text] [PDF]


Home page
JNMHome page
R. Jagathesan, P. A. Kaufmann, S. D. Rosen, O. E. Rimoldi, F. Turkeimer, R. Foale, and P. G. Camici
Assessment of the Long-Term Reproducibility of Baseline and Dobutamine-Induced Myocardial Blood Flow in Patients with Stable Coronary Artery Disease
J. Nucl. Med., February 1, 2005; 46(2): 212 - 219.
[Abstract] [Full Text] [PDF]


Home page
CirculationHome page
A. Lerman and A. M. Zeiher
Endothelial Function: Cardiac Events
Circulation, January 25, 2005; 111(3): 363 - 368.
[Full Text] [PDF]


Home page
CirculationHome page
S. D. Katz, K. Hryniewicz, I. Hriljac, K. Balidemaj, C. Dimayuga, A. Hudaihed, and A. Yasskiy
Vascular Endothelial Dysfunction and Mortality Risk in Patients With Chronic Heart Failure
Circulation, January 25, 2005; 111(3): 310 - 314.
[Abstract] [Full Text] [PDF]


Home page
JNMHome page
P. A. Kaufmann and P. G. Camici
Myocardial Blood Flow Measurement by PET: Technical Aspects and Clinical Applications
J. Nucl. Med., January 1, 2005; 46(1): 75 - 88.
[Full Text] [PDF]


Home page
Eur Heart JHome page
D. Fischer, S. Rossa, U. Landmesser, S. Spiekermann, N. Engberding, B. Hornig, and H. Drexler
Endothelial dysfunction in patients with chronic heart failure is independently associated with increased incidence of hospitalization, cardiac transplantation, or death
Eur. Heart J., January 1, 2005; 26(1): 65 - 69.
[Abstract] [Full Text] [PDF]


Home page
Eur J EchocardiogrHome page
M. Vanderheyden, J. Bartunek, S. Verstreken, L. Mortier, M. Goethals, and B. de Bruyne
Non-invasive assessment of coronary flow reserve in idiopathic dilated cardiomyopathy: hemodynamic correlations
Eur J Echocardiogr, January 1, 2005; 6(1): 47 - 53.
[Abstract] [Full Text] [PDF]


Home page
J Am Coll CardiolHome page
E. I. Skalidis, F. I. Parthenakis, A. P. Patrianakos, M. I. Hamilos, and P. E. Vardas
Regional coronary flow and contractile reserve in patients with idiopathic dilated cardiomyopathy
J. Am. Coll. Cardiol., November 16, 2004; 44(10): 2027 - 2032.
[Abstract] [Full Text] [PDF]


Home page
J. Physiol.Home page
D. J Green, A. Maiorana, G. O'Driscoll, and R. Taylor
Effect of exercise training on endothelium-derived nitric oxide function in humans
J. Physiol., November 15, 2004; 561(1): 1 - 25.
[Abstract] [Full Text] [PDF]


Home page
CirculationHome page
U. Landmesser, N. Engberding, F. H. Bahlmann, A. Schaefer, A. Wiencke, A. Heineke, S. Spiekermann, D. Hilfiker-Kleiner, C. Templin, D. Kotlarz, et al.
Statin-Induced Improvement of Endothelial Progenitor Cell Mobilization, Myocardial Neovascularization, Left Ventricular Function, and Survival After Experimental Myocardial Infarction Requires Endothelial Nitric Oxide Synthase
Circulation, October 5, 2004; 110(14): 1933 - 1939.
[Abstract] [Full Text] [PDF]


Home page
CirculationHome page
P. A. Kaufmann, O. Rimoldi, T. Gnecchi-Ruscone, R. S. Bonser, T. F. Luscher, and P. G. Camici
Systemic Inhibition of Nitric Oxide Synthase Unmasks Neural Constraint of Maximal Myocardial Blood Flow in Humans
Circulation, September 14, 2004; 110(11): 1431 - 1436.
[Abstract] [Full Text] [PDF]


Home page
Endocr. Rev.Home page
Z. Y. Fang, J. B. Prins, and T. H. Marwick
Diabetic Cardiomyopathy: Evidence, Mechanisms, and Therapeutic Implications
Endocr. Rev., August 1, 2004; 25(4): 543 - 567.
[Abstract] [Full Text] [PDF]


Home page
J. Appl. Physiol.Home page
D. J. Green, J. H. Walsh, A. Maiorana, V. Burke, R. R. Taylor, and J. G. O'Driscoll
Comparison of resistance and conduit vessel nitric oxide-mediated vascular function in vivo: effects of exercise training
J Appl Physiol, August 1, 2004; 97(2): 749 - 755.
[Abstract] [Full Text] [PDF]


Home page
FASEB J.Home page
V. STANGL, M. LORENZ, S. MEINERS, A. LUDWIG, C. BARTSCH, M. MOOBED, A. VIETZKE, H.-T. KINKEL, G. BAUMANN, and K. STANGL
Long-term up-regulation of eNOS and improvement of endothelial function by inhibition of the ubiquitin-proteasome pathway
FASEB J, February 1, 2004; 18(2): 272 - 279.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Heart Circ. Physiol.Home page
D. J. Green, J. H. Walsh, A. Maiorana, M. J. Best, R. R. Taylor, and J. G. O'Driscoll
Exercise-induced improvement in endothelial dysfunction is not mediated by changes in CV risk factors: pooled analysis of diverse patient populations
Am J Physiol Heart Circ Physiol, December 1, 2003; 285(6): H2679 - H2687.
[Abstract] [Full Text] [PDF]


Home page
Cardiovasc ResHome page
J.-N. Trochu, S. Mital, X.-p. Zhang, X. Xu, M. Ochoa, J. K Liao, F. A Recchia, and T. H Hintze
Preservation of NO production by statins in the treatment of heart failure
Cardiovasc Res, November 1, 2003; 60(2): 250 - 258.
[Abstract] [Full Text] [PDF]


Home page
J. Appl. Physiol.Home page
H. Post, J. Kajstura, B. Lei, W. C. Sessa, B. Byrne, P. Anversa, T. H. Hintze, and F. A. Recchia
Adeno-associated virus mediated gene delivery into coronary microvessels of chronically instrumented dogs
J Appl Physiol, October 1, 2003; 95(4): 1688 - 1694.
[Abstract] [Full Text] [PDF]


Home page
Physiol. Rev.Home page
D. L. Brutsaert
Cardiac Endothelial-Myocardial Signaling: Its Role in Cardiac Growth, Contractile Performance, and Rhythmicity
Physiol Rev, January 1, 2003; 83(1): 59 - 115.
[Abstract] [Full Text] [PDF]


Home page
Circ. Res.Home page
D. M. Kaye, M. M. Parnell, and B. A. Ahlers
Reduced Myocardial and Systemic L-Arginine Uptake in Heart Failure
Circ. Res., December 13, 2002; 91(12): 1198 - 1203.
[Abstract] [Full Text] [PDF]


Home page
CirculationHome page
U. Landmesser, S. Spiekermann, S. Dikalov, H. Tatge, R. Wilke, C. Kohler, D. G. Harrison, B. Hornig, and H. Drexler
Vascular Oxidative Stress and Endothelial Dysfunction in Patients With Chronic Heart Failure: Role of Xanthine-Oxidase and Extracellular Superoxide Dismutase
Circulation, December 10, 2002; 106(24): 3073 - 3078.
[Abstract] [Full Text] [PDF]


Home page
J Am Coll CardiolHome page
J. M. Hare, G. C. Nguyen, A. F. Massaro, J. M. Drazen, L. W. Stevenson, W. S. Colucci, J. C. Fang, W. Johnson, M. M. Givertz, and C. Lucas
Exhaled nitric oxide: a marker of pulmonary hemodynamics in heart failure
J. Am. Coll. Cardiol., September 18, 2002; 40(6): 1114 - 1119.
[Abstract] [Full Text] [PDF]


Home page
CirculationHome page
G. Theilmeier, P. Verhamme, S. Dymarkowski, H. Beck, H. Bernar, M. Lox, S. Janssens, M.-C. Herregods, E. Verbeken, D. Collen, et al.
Hypercholesterolemia in Minipigs Impairs Left Ventricular Response to Stress: Association With Decreased Coronary Flow Reserve and Reduced Capillary Density
Circulation, August 27, 2002; 106(9): 1140 - 1146.
[Abstract] [Full Text] [PDF]


Home page
CirculationHome page
D. Sun, A. Huang, S. Mital, M. R. Kichuk, C. C. Marboe, L. J. Addonizio, R. E. Michler, A. Koller, T. H. Hintze, and G. Kaley
Norepinephrine Elicits {beta}2-Receptor-Mediated Dilation of Isolated Human Coronary Arterioles
Circulation, July 30, 2002; 106(5): 550 - 555.
[Abstract] [Full Text] [PDF]


Home page
CirculationHome page
U. Landmesser and H. Drexler
Allopurinol and Endothelial Function in Heart Failure: Future or Fantasy?
Circulation, July 9, 2002; 106(2): 173 - 175.
[Full Text] [PDF]


Home page
Cardiovasc ResHome page
A. F.M van den Heuvel, J. J Bax, P. K Blanksma, W. Vaalburg, H. J.G.M Crijns, and D. J van Veldhuisen
Abnormalities in myocardial contractility, metabolism and perfusion reserve in non-stenotic coronary segments in heart failure patients
Cardiovasc Res, July 1, 2002; 55(1): 97 - 103.
[Abstract] [Full Text] [PDF]


Home page
J Am Coll CardiolHome page
J. L. Houghton, E. F. Philbin, D. S. Strogatz, M. T. Torosoff, S. A. Fein, P. A. Kuhner, V. E. Smith, and A. A. Carr
The presence of African American race predicts improvement in coronary endothelial function after supplementary L-arginine
J. Am. Coll. Cardiol., April 17, 2002; 39(8): 1314 - 1322.
[Abstract] [Full Text] [PDF]


Home page
CirculationHome page
D. Neglia, C. Michelassi, M. G. Trivieri, G. Sambuceti, A. Giorgetti, L. Pratali, M. Gallopin, P. Salvadori, O. Sorace, C. Carpeggiani, et al.
Prognostic Role of Myocardial Blood Flow Impairment in Idiopathic Left Ventricular Dysfunction
Circulation, January 15, 2002; 105(2): 186 - 193.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Heart Circ. Physiol.Home page
R. Nakamura, K. Egashira, K. Arimura, Y. Machida, T. Ide, H. Tsutsui, H. Shimokawa, and A. Takeshita
Increased inactivation of nitric oxide is involved in impaired coronary flow reserve in heart failure
Am J Physiol Heart Circ Physiol, December 1, 2001; 281(6): H2619 - H2625.
[Abstract] [Full Text] [PDF]


Home page
Cardiovasc ResHome page
J. H Traverse, Y. Chen, M. Crampton, S. Voss, and R. J Bache
Increased extravascular forces limit endothelium-dependent and -independent coronary vasodilation in congestive heart failure
Cardiovasc Res, December 1, 2001; 52(3): 454 - 461.
[Abstract] [Full Text] [PDF]


Home page
Cardiovasc ResHome page
M. Lepori, C. Sartori, H. Duplain, P. Nicod, and U. Scherrer
Interaction between cholinergic and nitrergic vasodilation: a novel mechanism of blood pressure control
Cardiovasc Res, September 1, 2001; 51(4): 767 - 772.
[Abstract] [Full Text] [PDF]


Home page
Eur Heart JHome page
S Adamopoulos, J Parissis, C Kroupis, M Georgiadis, D Karatzas, G Karavolias, K Koniavitou, A.J.S Coats, and D.T. Kremastinos
Physical training reduces peripheral markers of inflammation in patients with chronic heart failure
Eur. Heart J., May 1, 2001; 22(9): 791 - 797.
[Abstract] [PDF]


Home page
J Am Coll CardiolHome page
A. R. Patel, J. T. Kuvin, N. G. Pandian, J. J. Smith, J. E. Udelson, M. E. Mendelsohn, M. A. Konstam, and R. H. Karas
Heart failure etiology affects peripheral vascular endothelial function after cardiac transplantation
J. Am. Coll. Cardiol., January 1, 2001; 37(1): 195 - 200.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Heart Circ. Physiol.Home page
K. Arimura, K. Egashira, R. Nakamura, T. Ide, H. Tsutsui, H. Shimokawa, and A. Takeshita
Increased inactivation of nitric oxide is involved in coronary endothelial dysfunction in heart failure
Am J Physiol Heart Circ Physiol, January 1, 2001; 280(1): H68 - H75.
[Abstract] [Full Text] [PDF]


Home page
CirculationHome page
G. S. Nelson, R. D. Berger, B. J. Fetics, M. Talbot, J. C. Spinelli, J. M. Hare, and D. A. Kass
Left Ventricular or Biventricular Pacing Improves Cardiac Function at Diminished Energy Cost in Patients With Dilated Cardiomyopathy and Left Bundle-Branch Block
Circulation, December 19, 2000; 102(25): 3053 - 3059.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Heart Circ. Physiol.Home page
S. Mital, X. Zhang, G. Zhao, R. D. Bernstein, C. J. Smith, D. L. Fulton, W. C. Sessa, J. K. Liao, and T. H. Hintze
Simvastatin upregulates coronary vascular endothelial nitric oxide production in conscious dogs
Am J Physiol Heart Circ Physiol, December 1, 2000; 279(6): H2649 - H2657.
[Abstract] [Full Text] [PDF]


Home page
CirculationHome page
D. M. Kaye, B. A. Ahlers, D. J. Autelitano, and J. P. F. Chin-Dusting
In Vivo and In Vitro Evidence for Impaired Arginine Transport in Human Heart Failure
Circulation, November 28, 2000; 102(22): 2707 - 2712.
[Abstract] [Full Text] [PDF]


Home page
J Am Coll CardiolHome page
S. Mital, K. E. Loke, L. J. Addonizio, M. C. Oz, and T. H. Hintze
Left ventricular assist device implantation augments nitric oxide dependent control of mitochondrial respiration in failing human hearts
J. Am. Coll. Cardiol., November 15, 2000; 36(6): 1897 - 1902.
[Abstract] [Full Text] [PDF]


Home page
Eur Heart JHome page
F Boomsma, P.J de Kam, G Tjeerdsma, A.H van Den Meiracker, and D.J van Veldhuisen
Plasma semicarbazide-sensitive amine oxidase (SSAO) is an independent prognostic marker for mortality in chronic heart failure
Eur. Heart J., November 2, 2000; 21(22): 1859 - 1863.
[Abstract] [PDF]


Home page
RadiologyHome page
G. K. Lund, M. F. Wendland, A. Shimakawa, H. Arheden, F. Ståhlberg, C. B. Higgins, and M. Saeed
Coronary Sinus Flow Measurement by Means of Velocity-encoded Cine MR Imaging: Validation by Using Flow Probes in Dogs
Radiology, November 1, 2000; 217(2): 487 - 493.
[Abstract] [Full Text]


Home page
Am. J. Physiol. Heart Circ. Physiol.Home page
A. Maiorana, G. O'Driscoll, L. Dembo, C. Cheetham, C. Goodman, R. Taylor, and D. Green
Effect of aerobic and resistance exercise training on vascular function in heart failure
Am J Physiol Heart Circ Physiol, October 1, 2000; 279(4): H1999 - H2005.
[Abstract] [Full Text] [PDF]


Home page
CirculationHome page
P. A. Kaufmann, T. Gnecchi-Ruscone, M. di Terlizzi, K. P. Schafers, T. F. Luscher, and P. G. Camici
Coronary Heart Disease in Smokers : Vitamin C Restores Coronary Microcirculatory Function
Circulation, September 12, 2000; 102(11): 1233 - 1238.
[Abstract] [Full Text] [PDF]


Home page
ChestHome page
J. L. Houghton, T. A. Pearson, R. G. Reed, M. T. Torosoff, N. L. Henches, P. A. Kuhner, and E. F. Philbin
Cholesterol Lowering With Pravastatin Improves Resistance Artery Endothelial Function : Report of Six Subjects With Normal Coronary Arteriograms
Chest, September 1, 2000; 118(3): 756 - 760.
[Abstract] [Full Text] [PDF]