Circulation, Vol 81, 1415-1418, Copyright © 1990 by American Heart Association
H Vierhapper, O Wagner, P Nowotny and W Waldhausl
The effect of an intravenous infusion of human endothelin-1 on blood
pressure and plasma concentrations of endothelin-1, potassium, sodium,
renin, aldosterone, and atrial natriuretic factor was investigated in six
healthy, sodium-loaded men. During the peptide's exogenous application
(1.0, 2.5, and 5.0 ng/kg.min), its plasma concentrations rose from a basal
value of 1.2 +/- 0.3 to 3.2 +/- 1.9, 9.9 +/- 7.6, and 56.5 +/- 50.3 pmol/l
(p less than 0.01), respectively, and mean blood pressure rose from a basal
value of 87.1 +/- 7.3 to 92.6 +/- 8.2 mm Hg (p less than 0.01). A rise in
serum concentrations of potassium (from 4.0 +/- 0.3 to 4.6 +/- 0.2 mmol/l;
p less than 0.005) and a concomitant fall in serum concentrations of sodium
(from 142.7 +/- 1.0 to 139.5 +/- 2.3 mmol/l; p less than 0.05) was seen in
each subject. Plasma concentrations of renin, aldosterone, and atrial
natriuretic factor did not change during the infusion of endothelin-1.
Thus, in the doses used, endothelin-1 induces a rise in blood pressure and
serum potassium concentrations.
ARTICLES
Effect of endothelin-1 in man
I. Medizinische Universitatsklinik, Division of Clinical Endocrinology and Diabetes Mellitus, Wien, Austria.
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