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Circulation, Vol 81, 1959-1966, Copyright © 1990 by American Heart Association
W Wang, JS Chen and IH Zucker
Single-unit carotid sinus baroreceptor activity was recorded in normal and
heart-failure (pacing-induced) dogs. The sensitivity of these units was
compared between the two groups of dogs. After development of clinical
heart failure, the animals were anesthetized, and the left carotid sinus
was vascularly isolated and perfused with oxygenated Krebs-Henseleit
solution. Single-unit baroreceptor discharge was recorded from the carotid
sinus nerve in response to stepwise increases in carotid sinus pressure
(CSP). In addition, the carotid sinus diameter was measured with
sonomicrometer crystals. In this way, both CSP-discharge and CSP-diameter
curves were constructed for both normal and heart-failure dogs. Analysis of
these curves demonstrated that the heart-failure group exhibited a
significant decrease in peak discharge (48.1 +/- 3.0 vs. 22.2 +/- 2.2
spikes/sec; p less than 0.001) and a significant elevation in threshold
pressure compared with the normal animals (91.0 +/- 5.0 vs. 119.1 +/- 4.4
mm Hg; p less than 0.001). The peak slope of the CSP-discharge curve was
also significantly lower in the heart-failure group (0.63 +/- 0.06 vs. 0.40
+/- 0.09 spikes/sec/mm Hg; p less than 0.05). In the heart-failure group,
perfusion of the carotid sinus with ouabain (0.01 micrograms/ml) caused a
significant decrease in threshold pressure and a significant increase in
peak discharge frequency, as well as an increase in slope of the CSP-
discharge curve. There were no changes in CSP-diameter relations in
response to ouabain. This dose of ouabain had no effect on pressure-
discharge relations or carotid sinus diameters in normal dogs.(ABSTRACT
TRUNCATED AT 250 WORDS)
ARTICLES
Carotid sinus baroreceptor sensitivity in experimental heart failure
Department of Physiology and Biophysics, University of Nebraska College of Medicine, Omaha 68105.
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