Circulation, Vol 82, 140-146, Copyright © 1990 by American Heart Association
S De Servi, A Mazzone, G Ricevuti, A Fioravanti, E Bramucci, L Angoli, G Stefano and G Specchia
To determine whether percutaneous transluminal coronary angioplasty (PTCA)
would lead to neutrophil activation with subsequent discharge of
proteolytic enzymes, like elastase, and oxygen free radicals, like
superoxide anion, blood samples were taken from the coronary sinus and
aorta in 14 patients with stable angina and one-vessel disease who
underwent PTCA. Neutrophils were separated by means of the Ficoll- Hypaque
system and were stimulated to detect release of elastase and generation of
superoxide anion. Plasma levels of elastase were also measured by an
immunoenzymatic method. PTCA was successful in all patients. Plasma
elastase levels increased significantly at the end of the procedure
compared with pre-PTCA values both in the coronary sinus (from 129.2 +/-
16.6 to 286.6 +/- 39.7 micrograms/l, p less than 0.005) and in the aorta
(from 117.4 +/- 13.6 to 258.1 +/- 41.3 micrograms/l, p less than 0.005). On
the other hand, superoxide anion released in the supernatants after
neutrophil stimulation by phorbol-myristate-acetate decreased after PTCA in
the coronary sinus (before PTCA, 60.1 +/- 7.1; after PTCA, 40.7 +/- 6.8
nmol 1 x 10(7) granulocytes/ml/15 min, p less than 0.05), whereas a mild
but not significant decrease was observed in the aorta (from 58.3 +/- 10.9
to 55.3 +/- 8.6 nmol 1 x 10(7) granulocytes/ml/15 min, p = NS).(ABSTRACT
TRUNCATED AT 250 WORDS)
ARTICLES
Granulocyte activation after coronary angioplasty in humans
Division of Cardiology, University of Pavia, IRCCS San Matteo Hospital, Italy.
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