This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Herrero, P. Articles by Bergmann, S. R. Search for Related Content PubMed PubMed Citation Articles by Herrero, P. Articles by Bergmann, S. R.

Circulation, Vol 82, 1377-1386, Copyright © 1990 by American Heart Association

ARTICLES

Noninvasive quantification of regional myocardial perfusion with rubidium-82 and positron emission tomography. Exploration of a mathematical model

P Herrero, J Markham, ME Shelton, CJ Weinheimer and SR Bergmann
Cardiovascular Division, Washington University School of Medicine, St. Louis, Missouri 63110.

Positron emission tomography (PET) centers without cyclotrons use generator-produced rubidium-82 (82Rb) for assessment of myocardial perfusion. The aim of the present study was to determine whether myocardial blood flow could be assessed quantitatively with 82Rb and PET. Because the myocardial extraction fraction of 82Rb varies inversely and nonlinearly with flow and cannot be measured conveniently with PET, we used an experimentally derived mathematical function defining the relation between single-pass extraction fraction of 82Rb and flow to obviate the necessity of measuring the extraction fraction directly. Myocardial blood flow in absolute terms (ml/g/min) was estimated from dynamic PET scans after intravenous administration of 82Rb in intact dogs and compared with flows measured with radiolabeled microspheres. In 36 comparisons in 13 dogs studied at rest, or after coronary occlusion, reperfusion, or after coronary hyperemia induced with intravenous dipyridamole, over the flow range from 0.2 to 2.0 ml/g/min, estimates of perfusion with rubidium correlated well with flows measured concomitantly with microspheres, although there was a slight underestimation of flow with rubidium (flow by 82Rb = 0.92 x flow by microspheres-0.021, r = 0.83). In general, estimates of flow in ischemic regions were less reliable than estimates for regions with normal flow. Thus, although the relation between myocardial extraction and retention of 82Rb and flow can vary under a variety of physiological and pathophysiological conditions, this study demonstrates the ability to obtain quantitative estimates of myocardial blood flow with 82Rb and PET under carefully defined conditions without measuring the extraction fraction directly.

This article has been cited by other articles:

				G. El Fakhri, A. Kardan, A. Sitek, S. Dorbala, N. Abi-Hatem, Y. Lahoud, A. Fischman, M. Coughlan, T. Yasuda, and M. F. Di Carli Reproducibility and Accuracy of Quantitative Myocardial Blood Flow Assessment with 82Rb PET: Comparison with 13N-Ammonia PET J. Nucl. Med., July 1, 2009; 50(7): 1062 - 1071. [Abstract] [Full Text] [PDF]

				I. Madar, H. Ravert, A. DiPaula, Y. Du, R. F. Dannals, and L. Becker Assessment of Severity of Coronary Artery Stenosis in a Canine Model Using the PET Agent 18F-Fluorobenzyl Triphenyl Phosphonium: Comparison with 99mTc-Tetrofosmin J. Nucl. Med., June 1, 2007; 48(6): 1021 - 1030. [Abstract] [Full Text] [PDF]

				P. A. Kaufmann and P. G. Camici Myocardial Blood Flow Measurement by PET: Technical Aspects and Clinical Applications J. Nucl. Med., January 1, 2005; 46(1): 75 - 88. [Full Text] [PDF]

				G. D. Hutchins What Is the Best Approach to Quantify Myocardial Blood Flow with PET? J. Nucl. Med., August 1, 2001; 42(8): 1183 - 1184. [Full Text] [PDF]

				J.-W. Lin, A. F. Laine, O. Akinboboye, and S. R. Bergmann Use of Wavelet Transforms in Analysis of Time-Activity Data from Cardiac PET J. Nucl. Med., February 1, 2001; 42(2): 194 - 200. [Abstract] [Full Text]

				J.-W. Lin, R. R. Sciacca, R.-L. Chou, A. F. Laine, and S. R. Bergmann Quantification of Myocardial Perfusion in Human Subjects Using 82Rb and Wavelet-Based Noise Reduction J. Nucl. Med., February 1, 2001; 42(2): 201 - 208. [Abstract] [Full Text]

				J. vom Dahl, O. Muzik, E. R. Wolfe Jr, C. Allman, G. Hutchins, and M. Schwaiger Myocardial Rubidium-82 Tissue Kinetics Assessed by Dynamic Positron Emission Tomography as a Marker of Myocardial Cell Membrane Integrity and Viability Circulation, January 15, 1996; 93(2): 238 - 245. [Abstract] [Full Text]

				N. G. Uren, J. A. Melin, B. De Bruyne, W. Wijns, T. Baudhuin, and P. G. Camici Relation between Myocardial Blood Flow and the Severity of Coronary-Artery Stenosis N. Engl. J. Med., June 23, 1994; 330(25): 1782 - 1788. [Abstract] [Full Text]