Circulation, Vol 82, 1778-1789, Copyright © 1990 by American Heart Association
DM Roth, FC White, ML Nichols, SL Dobbs, JC Longhurst and CM Bloor
The effect of myocardial ischemia, induced by long-term exercise, on
regional myocardial function and coronary collateral development was
examined in pigs after gradual occlusion of the left circumflex coronary
artery (LCx) with an ameroid occluder. Thirty days after surgery, regional
myocardial function and blood flow were assessed during exercise in 22 pigs
separated into exercise (n = 12) and sedentary groups (n = 10). The
exercise group trained on a treadmill for 25 +/- 1 days, 30-50 min/day, at
heart rates of 210-220 beats/min. After 5 weeks, another exercise test was
performed. In the exercise group, after training, we observed an
improvement in systolic wall thickening, expressed as a percentage of rest,
in the collateral- dependent LCx region from 64 +/- 8% to 87 +/- 6% (p less
than 0.01) at moderate exercise levels (220 beats/min) and from 45 +/- 7%
to 73 +/- 7% (p less than 0.01) at severe exercise levels (265 beats/min).
Transmural myocardial blood flow in the LCx region expressed as a ratio of
flow in the nonoccluded region of the left ventricle also increased
significantly (p less than 0.01) during severe exercise after 5 weeks. The
sedentary group showed an improvement in systolic wall thickening in the
LCx region during moderate exercise compared with the initial exercise test
(p less than 0.05) but no significant change in systolic wall thickening or
myocardial blood flow ratios during severe exercise after 5 weeks. We
conclude that long-term exercise after gradual LCx coronary artery
occlusion in pigs improves myocardial function and coronary collateral
reserve in collateral-dependent myocardium during exercise.
ARTICLES
Effect of long-term exercise on regional myocardial function and coronary collateral development after gradual coronary artery occlusion in pigs
Department of Pathology, University of California, San Diego 92093.
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