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Circulation, Vol 82, 1900-1909, Copyright © 1990 by American Heart Association

ARTICLES

Pathophysiological insights into the cardiomyopathy of Chagas' disease

SA Morris, HB Tanowitz, M Wittner and JP Bilezikian
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032.

The evidence gained from both human and animal studies of chronic chagasic cardiomyopathy suggests that the disease occurs as a consequence of several discrete and progressive pathophysiological processes occurring after infection, the ultimate expression of which depends on a host of unidentified factors. Collectively, the infection- associated events compromise microvasculature function and result in hypoperfusion, with consequences indistinguishable from those observed in other, nonparasitological cardiomyopathic diseases secondary to hypoperfusion. Therefore, chronic chagasic cardiomyopathy may share similar pathophysiological abnormalities with other chronic congestive cardiomyopathic states.

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