Circulation, Vol 82, 2115-2127, Copyright © 1990 by American Heart Association
S Watabe, B Taccardi, RL Lux and PR Ershler
The effect of nontransmural necrosis on epicardial potential distributions
was studied in 13 dogs. In previous studies, left ventricular epicardial
pacing generated epicardial potential maps at QRS onset with a negative
central area and two positive areas that faced the portions of the
wavefront propagating along fibers. Subsequently, the positive areas
expanded in a counterclockwise direction by 90 degrees to 120 degrees. In
those studies, the rotatory expansion of the positive areas was tentatively
attributed to the spread of excitation through deep myocardial layers,
where fiber direction rotated counterclockwise from epicardium to
endocardium. To test this hypothesis, we tried to interrupt the
counterclockwise expansion of the positive area by creating localized,
nontransmural necrosis at various depths in the left ventricular wall by
injection of formalin or application of laser energy. Epicardial potential
maps were obtained from a grid of 12 x 15 electrodes on a 44 x 56-mm area.
Epicardial pacing from selected sites generated epicardial maps in which
some positive areas were missing compared with controls. The direction of
the straight line joining the pacing site to the site of missing positivity
correlated well with the average fiber direction in the necrotic mass (r =
0.82, p less than 0.01). Angle between epicardial fiber direction and the
straight line described above correlated well with the average depth of the
necrosis, expressed as percent of the wall thickness (r = 0.95, p less than
0.01). These data support the hypothesis that the counterclockwise
expansion of the epicardial positivity occurring after epicardial pacing
results from excitation spreading along deep fibers.(ABSTRACT TRUNCATED AT
250 WORDS)
ARTICLES
Effect of nontransmural necrosis on epicardial potential fields. Correlation with fiber direction
Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah School of Medicine, Salt Lake City 84112.
This article has been cited by other articles:
 |
|
 |
|
  J. E. Burnes, B. Taccardi, R. S. MacLeod, and Y. Rudy Noninvasive ECG Imaging of Electrophysiologically Abnormal Substrates in Infarcted Hearts : A Model Study Circulation, February 8, 2000; 101(5): 533 - 540. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Macchi, M. Cavalieri, D. Stilli, E. Musso, S. Baruffi, G. Olivetti, P. R. Ershler, R. L. Lux, and B. Taccardi High-density epicardial mapping during current injection and ventricular activation in rat hearts Am J Physiol Heart Circ Physiol, November 1, 1998; 275(5): H1886 - H1897. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. S. Oster, B. Taccardi, R. L. Lux, P. R. Ershler, and Y. Rudy Electrocardiographic Imaging : Noninvasive Characterization of Intramural Myocardial Activation From Inverse-Reconstructed Epicardial Potentials and Electrograms Circulation, April 21, 1998; 97(15): 1496 - 1507. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Hatala, P. Savard, G. Tremblay, P. Page, R. Cardinal, F. Molin, T. Kus, and R. Nadeau Three Distinct Patterns of Ventricular Activation in Infarcted Human Hearts : An Intraoperative Cardiac Mapping Study During Sinus Rhythm Circulation, March 1, 1995; 91(5): 1480 - 1494. [Abstract] [Full Text]
|
|
|
|
|
|
D. S. Khoury, B. Taccardi, R. L. Lux, P. R. Ershler, and Y. Rudy Reconstruction of Endocardial Potentials and Activation Sequences From Intracavitary Probe Measurements : Localization of Pacing Sites and Effects of Myocardial Structure Circulation, February 1, 1995; 91(3): 845 - 863. [Abstract] [Full Text]
|
|