Circulation, Vol 82, 2190-2200, Copyright © 1990 by American Heart Association
RS Schwartz, JG Murphy, WD Edwards, AR Camrud, RE Vliestra and DR Holmes
A model of proliferative human restenosis was developed in domestic pigs by
using deep injury to the coronary arterial media. Metal wire coils were
delivered percutaneously to the coronary arteries of 11 pigs with an
oversized, high-pressure (14 atm) balloon and were left in place for times
ranging from 28 to 70 days. During placement, the balloon expanded the
coils and delivered them securely within the arterial lumen. Light
microscopic examination of the vessels confirmed fracture of the internal
elastic lamina by the coil. An extensive proliferative response occurred in
10 of the 11 pigs and was associated with a luminal area narrowing of at
least 50% in all but one pig. The histopathologic features of the
proliferative response were identical to those observed in human cases of
restenosis after angioplasty. Immunohistochemical studies confirmed the
prominence of smooth muscle cells in the proliferative tissue. A similar
response was obtained in two of five porcine coronary arteries in which
balloon inflation only was performed, without coil implant. This model is
practical and inexpensive and closely mimics the proliferative portion of
human restenosis both grossly and microscopically. Thus, it may be useful
for understanding human restenosis and for testing therapies aimed at
preventing restenosis after balloon angioplasty or other coronary
interventional procedures.
ARTICLES
Restenosis after balloon angioplasty. A practical proliferative model in porcine coronary arteries
Division of Cardiovascular Diseases and Internal Medicine, Mayo Graduate School of Medicine, Mayo Clinic and Foundation, Rochester, Minn 55905.
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