Circulation, Vol 83, 438-447, Copyright © 1991 by American Heart Association
DH Blankenhorn, SP Azen, DW Crawford, SA Nessim, ME Sanmarco, RH Selzer, AM Shircore and EC Wickham
The 2-year therapy effect on femoral atherosclerosis was evaluated in the
Cholesterol Lowering Atherosclerosis Study (CLAS), a randomized,
placebo-plus-diet-controlled angiographic trial of colestipol-niacin
therapy plus diet in men with previous coronary bypass surgery. Different
diet compositions were prescribed to enhance the differential in blood
cholesterol responses between the two groups. The annual rate of change in
computer-estimated atherosclerosis (CEA), a measure of lumen abnormality,
was evaluated between treatment groups. A significant per-segment therapy
effect was found in segments with moderately severe atherosclerosis (p less
than 0.04) and in proximal segments (p less than 0.02). When segmental CEA
measures were combined into a per-patient score using an adaptation of the
National Heart, Lung, and Blood Institute scoring procedure, a significant
therapy effect was observed (p less than 0.02). Total variance of the
annual change rate in CEA was as predicted from pilot studies, but
measurement variation was larger. The therapy effect observed in femoral
arteries, although significant, was less marked than the strong and
consistent benefit previously reported for both native coronary arteries
and aortocoronary bypass grafts.
ARTICLES
Effects of colestipol-niacin therapy on human femoral atherosclerosis
Department of Medicine, University of Southern California, Los Angeles 90033.
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