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Circulation, Vol 83, 504-514, Copyright © 1991 by American Heart Association
J Schaper, R Froede, S Hein, A Buck, H Hashizume, B Speiser, A Friedl and N Bleese
This study was designed to determine the morphological correlate of chronic
heart failure. Myocardial tissue from eight patients undergoing
transplantation surgery because of end-stage dilated cardiomyopathy was
investigated by electron microscopy and immunocytochemistry using
monoclonal antibodies against elements of the cytoskeleton: desmin,
tubulin, vinculin, and vimentin. The tissue showed hypertrophy, atrophy of
myocytes, and an increased amount of fibrosis. Ultrastructural changes
consisted of enlargement and varying shape of nuclei, numerous very small
mitochondria, proliferation of T tubules, and accumulation of lipid
droplets and glycogen. The most obvious ultrastructural alteration was the
decrease of myofilaments, ranging from rarefication to complete absence of
sarcomeres in cells filled with unspecified cytoplasm. Immunocytochemistry
showed that desmin was localized at the Z lines. In diseased myocardium,
the amount of desmin was increased, but it was disorderly arranged. Tubulin
formed a fine network throughout the myocytes and was significantly
increased in cardiomyopathic hearts. Vinculin, a protein closely associated
with the cytoskeleton, occurred not only at the sarcolemma and the
intercalated disc but also within the myocardial cells. Ultrastructural
changes and alterations of the cytoskeleton were severe in about one third
of all cells. About one third of all cells showed moderately severe
changes, and the remaining cells were normal. Vimentin was present in the
interstitial cells and was increased in relation to the increase of
fibrosis. We conclude that the increase of fibrosis, the degeneration of
hypertrophied myocardial cells, and the alterations of the cytoskeleton are
the morphological correlates of reduced myocardial function in chronic
heart failure.
ARTICLES
Impairment of the myocardial ultrastructure and changes of the cytoskeleton in dilated cardiomyopathy
Department of Experimental Cardiology, Max-Planck-Institute for Physiological and Clinical Research, Nauheim, FRG.
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M. A. Sussman, S. Welch, N. Gude, P. R. Khoury, S. R. Daniels, D. Kirkpatrick, R. A. Walsh, R. L. Price, H. W. Lim, and J. D. Molkentin Pathogenesis of Dilated Cardiomyopathy : Molecular, Structural, and Population Analyses inTropomodulin-Overexpressing Transgenic Mice Am. J. Pathol., December 1, 1999; 155(6): 2101 - 2113. [Abstract] [Full Text] [PDF] |
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C.F. Vahl, T. Kloss, Y. Yang, M. Castell, A. Mehrkens, R. deSimone, L. Schaffer, and S. Hagl Surgical treatment of oligosymptomatic mitral valve incompetence? Eur. J. Cardiothorac. Surg., November 1, 1999; 16(5): 524 - 532. [Abstract] [Full Text] [PDF] |
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J. Schaper, A. Elsasser, and S. Kostin The Role of Cell Death in Heart Failure Circ. Res., October 29, 1999; 85(9): 867 - 869. [Full Text] [PDF] |
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D. L. Mann Mechanisms and Models in Heart Failure : A Combinatorial Approach Circulation, August 31, 1999; 100(9): 999 - 1008. [Full Text] [PDF] |
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J. E. Saffitz, R. B. Schuessler, and K. A. Yamada Mechanisms of remodeling of gap junction distributions and the development of anatomic substrates of arrhythmias Cardiovasc Res, May 1, 1999; 42(2): 309 - 317. [Full Text] [PDF] |
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A. C. Cicogna, K. G. Robinson, C. H. Conrad, K. Singh, R. Squire, M. P. Okoshi, and O. H. L. Bing Direct Effects of Colchicine on Myocardial Function : Studies in Hypertrophied and Failing Spontaneously Hypertensive Rats Hypertension, January 1, 1999; 33(1): 60 - 65. [Abstract] [Full Text] [PDF] |
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H. F. Clemo, B. S. Stambler, and C. M. Baumgarten Persistent Activation of a Swelling-Activated Cation Current in Ventricular Myocytes From Dogs With Tachycardia-Induced Congestive Heart Failure Circ. Res., July 27, 1998; 83(2): 147 - 157. [Abstract] [Full Text] [PDF] |
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G. Hasenfuss Animal models of human cardiovascular disease, heart failure and hypertrophy Cardiovasc Res, July 1, 1998; 39(1): 60 - 76. [Abstract] [Full Text] [PDF] |
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H. A. Rockman, K. R. Chien, D.-J. Choi, G. Iaccarino, J. J. Hunter, J. Ross Jr., R. J. Lefkowitz, and W. J. Koch Expression of a beta -adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice PNAS, June 9, 1998; 95(12): 7000 - 7005. [Abstract] [Full Text] [PDF] |
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R. R. Kaprielian, M. Gunning, E. Dupont, M. N. Sheppard, S. M. Rothery, R. Underwood, D. J. Pennell, K. Fox, J. Pepper, P. A. Poole-Wilson, et al. Downregulation of Immunodetectable Connexin43 and Decreased Gap Junction Size in the Pathogenesis of Chronic Hibernation in the Human Left Ventricle Circulation, February 24, 1998; 97(7): 651 - 660. [Abstract] [Full Text] [PDF] |
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P. P de Tombe Altered contractile function in heart failure Cardiovasc Res, February 1, 1998; 37(2): 367 - 380. [Abstract] [Full Text] [PDF] |
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M. C. Schaub, M. A. Hefti, R. A. Zuellig, and I. Morano Modulation of contractility in human cardiac hypertrophy by myosin essential light chain isoforms Cardiovasc Res, February 1, 1998; 37(2): 381 - 404. [Abstract] [Full Text] [PDF] |
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M. Pauschinger, A. Doerner, A. Remppis, R. Tannhauser, U. Kuhl, and H.-P. Schultheiss Differential myocardial abundance of collagen type I and type III mRNA in dilated cardiomyopathy: effects of myocardial inflammation Cardiovasc Res, January 1, 1998; 37(1): 123 - 129. [Abstract] [Full Text] [PDF] |
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I. S. Anand, D. Liu, S. S. Chugh, A. J.C. Prahash, S. Gupta, R. John, F. Popescu, and Y. Chandrashekhar Isolated Myocyte Contractile Function Is Normal in Postinfarct Remodeled Rat Heart With Systolic Dysfunction Circulation, December 2, 1997; 96(11): 3974 - 3984. [Abstract] [Full Text] |
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A. Elsasser, M. Schlepper, W.-P. Klovekorn, W.-j. Cai, R. Zimmermann, K.-D. Muller, R. Strasser, S. Kostin, C. Gagel, B. Munkel, et al. Hibernating Myocardium : An Incomplete Adaptation to Ischemia Circulation, November 4, 1997; 96(9): 2920 - 2931. [Abstract] [Full Text] |
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E. Missov, C. Calzolari, and B. Pau Circulating Cardiac Troponin I in Severe Congestive Heart Failure Circulation, November 4, 1997; 96(9): 2953 - 2958. [Abstract] [Full Text] |
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A. M. Gómez, H. H. Valdivia, H. Cheng, M. R. Lederer, L. F. Santana, M. B. Cannell, S. A. McCune, R. A. Altschuld, and W. J. Lederer Defective Excitation-Contraction Coupling in Experimental Cardiac Hypertrophy and Heart Failure Science, May 2, 1997; 276(5313): 800 - 806. [Abstract] [Full Text] |
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S. Stevenson, S. Rothery, M. J. Cullen, and N. J. Severs Dystrophin Is Not a Specific Component of the Cardiac Costamere Circ. Res., February 1, 1997; 80(2): 269 - 280. [Abstract] [Full Text] |
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M. Maeda, E. Holder, B. Lowes, S. Valent, and R. D. Bies Dilated Cardiomyopathy Associated With Deficiency of the Cytoskeletal Protein Metavinculin Circulation, January 7, 1997; 95(1): 17 - 20. [Abstract] [Full Text] |
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M. A. Sussman, S. F. Hamm-Alvarez, P. M. Vilalta, S. Welch, and L. Kedes Involvement of Phosphorylation in Doxorubicin-Mediated Myofibril Degeneration: An Immunofluorescence Microscopy Analysis Circ. Res., January 1, 1997; 80(1): 52 - 61. [Abstract] [Full Text] |
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K. T. Sun, J. Czernin, J. Krivokapich, Y.-K. Lau, M. Bottcher, G. Maurer, M. E. Phelps, and H. R. Schelbert Effects of Dobutamine Stimulation on Myocardial Blood Flow, Glucose Metabolism, and Wall Motion in Normal and Dysfunctional Myocardium Circulation, December 15, 1996; 94(12): 3146 - 3154. [Abstract] [Full Text] |
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M. N. Sack, T. A. Rader, S. Park, J. Bastin, S. A. McCune, and D. P. Kelly Fatty Acid Oxidation Enzyme Gene Expression Is Downregulated in the Failing Heart Circulation, December 1, 1996; 94(11): 2837 - 2842. [Abstract] [Full Text] |
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H. Meng, J. J. Leddy, J. Frank, P. Holland, and B. S. Tuana The Association of Cardiac Dystrophin with Myofibrils/Z-disc Regions in Cardiac Muscle Suggests a Novel Role in the Contractile Apparatus J. Biol. Chem., May 24, 1996; 271(21): 12364 - 12371. [Abstract] [Full Text] [PDF] |
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D. R. Meldrum, J. C. Cleveland Jr, B. C. Sheridan, R. T. Rowland, A. Banerjee, and A. H. Harken Cardiac Surgical Implications of Calcium Dyshomeostasis in the Heart Ann. Thorac. Surg., April 1, 1996; 61(4): 1273 - 1280. [Abstract] [Full Text] |
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