Circulation, Vol 83, 1305-1314, Copyright © 1991 by American Heart Association
KH Bonaa and DS Thelle
BACKGROUND. High blood pressure has been associated with elevated
atherogenic blood lipid fractions, but epidemiological surveys often give
inconsistent results across population subgroups. A better understanding of
the relation between blood pressure and blood lipids may provide insight
into the mechanism(s) whereby hypertension is associated with increased
risk of coronary heart disease. METHODS AND RESULTS. We assessed the
cross-sectional relations of serum total cholesterol, high density
lipoprotein (HDL) cholesterol, non-HDL cholesterol (total minus HDL
cholesterol), and triglyceride levels with blood pressure in a population
of 8,081 men 20-54 years old and 7,663 women 20-49 years old. Stratified
analyses and multivariable methods were used to control for potential
confounding anthropometric and lifestyle variables. Total and non-HDL
cholesterol levels increased significantly with increasing systolic or
diastolic blood pressure in both sexes. Men 20-29 years old had steeper
regression slopes for blood pressure by total cholesterol level than did
women of similar age. In men, the association between blood pressure and
total cholesterol level decreased with age, whereas in women, it increased
with age. Body mass index modified the relation, whereas smoking, physical
activity, and alcohol consumption had little influence on the association.
Triglyceride levels increased with blood pressure, but this relation was
weak in lean subjects. HDL cholesterol level correlated positively with
blood pressure in population subgroups having a high alcohol consumption.
CONCLUSION. These results support the hypothesis that there are biological
interrelations between blood pressure and blood lipids that may influence
the mechanisms whereby blood pressure is associated with risk of coronary
heart disease.
ARTICLES
Association between blood pressure and serum lipids in a population. The Tromso Study
Institute of Community Medicine, University of Tromso, Norway.
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