Circulation, Vol 83, 1327-1332, Copyright © 1991 by American Heart Association
M Ueda, AE Becker, T Tsukada, F Numano and T Fujimoto
BACKGROUND. Restenosis after initial, successful percutaneous transluminal
coronary angioplasty (PTCA) is due to fibrocellular proliferation. METHODS
AND RESULTS. The present study focused on the nature of fibrocellular
tissue in humans by use of immunocytochemical techniques. Four hearts (five
coronary arteries) were investigated; time lapse between PTCA and death
varied between 20 days (two arteries) and 1 year 7 months. Proliferating
cells stained positive with smooth muscle cell-specific monoclonal
antibodies. Cells from early proliferative lesions (20 days) have a
phenotypic expression different from cells in "old" lesions. Proliferating
cells stained positive with vimentin but were negative with desmin,
irrespective of the lesion's age. CONCLUSIONS. The findings indicate a
change in actin isoform expression of smooth muscle cells while adapting to
a pathological state.
ARTICLES
Fibrocellular tissue response after percutaneous transluminal coronary angioplasty. An immunocytochemical analysis of the cellular composition
Department of Pathology, Osaka City University Medical School.
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