Circulation, Vol 83, 1692-1697, Copyright © 1991 by American Heart Association
JR Stratton, WL Chandler, RS Schwartz, MD Cerqueira, WC Levy, SE Kahn, VG Larson, KC Cain, JC Beard and IB Abrass
BACKGROUND. The effects of 6 months of intensive endurance exercise
training on resting tissue-type plasminogen activator (t-PA) activity,
plasminogen activator inhibitor type 1 (PAI-1) activity, t-PA antigen, and
fibrinogen were studied in 10 young (24-30 years) and in 13 old male
subjects (60-82 years). METHODS AND RESULTS. After training, maximum oxygen
consumption was increased in the young group by 18% (44.9 +/- 5.0 to 52.9
+/- 6.6 ml/kg/min, p less than 0.001), whereas it was increased in the old
group by 22% (29.0 +/- 4.2 to 35.5 +/- 3.6 ml/kg/min, p less than 0.001).
The young group had no significant changes in any of the measured
variables, whereas the old group had a 39% increase in t-PA activity (0.82
+/- 0.47 to 1.14 +/- 0.42 IU/ml, p less than 0.03), a 141% increase in the
percentage of t-PA in the active form (11.1 +/- 7.7 to 26.8 +/- 15.1%, p
less than 0.01), a 58% decrease in PAI-1 activity (8.4 +/- 4.9 to 3.5 +/-
1.7 AU/ml, p less than 0.01), and a 13% decrease in fibrinogen (3.57 +/-
0.79 to 3.11 +/- 0.52 g/l, p less than 0.01). CONCLUSIONS. We conclude that
intensive exercise training enhances resting t-PA activity and reduces
fibrinogen and PAI-1 activity in older men. These effects are potential
mechanisms by which habitual physical activity might reduce the risk of
cardiovascular disease.
ARTICLES
Effects of physical conditioning on fibrinolytic variables and fibrinogen in young and old healthy adults
Division of Cardiology, Seattle VA Medical Center, WA 98108.
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