Circulation, Vol 83, 1788-1798, Copyright © 1991 by American Heart Association
WJ van der Giessen, PW Serruys, HM van Beusekom, LJ van Woerkens, H van Loon, LK Soei, BH Strauss, KJ Beatt and PD Verdouw
BACKGROUND. Intracoronary stents may be effective when used as "bail- out"
devices for acute complications after percutaneous transluminal coronary
angioplasty. Furthermore, preliminary reports have demonstrated some
promising results with stents with regard to the reduction of restenosis.
Several stent devices are available for preclinical and clinical
evaluation. The use of these stainless-steel stents has been limited by
poor visibility during fluoroscopy and thrombogenicity during the first
days to weeks after implantation. We therefore investigated the immediate
and short-term effects on arterial patency of a new, radiopaque,
balloon-expandable coil stent in normal coronary arteries of pigs. METHODS
AND RESULTS. In 10 animals, a stent was placed in two of the three
epicardial coronary arteries. During the implantation procedure, the
animals received heparin; after the procedure, no antithrombotic drugs were
administered. After 1 week (five animals and 10 stents) or 4 weeks (five
animals and 10 stents), repeat angiography was performed, followed by
pressure-fixation of the coronary arteries for light and electron
microscopic examination. Angiographic analysis revealed that all stented
coronary segments were patent and without signs of intraluminal defects.
Scanning electron microscopy showed complete endothelial covering of all
stents within 7 days. Light microscopy showed a reduced tunica media
locally under the stent wires, which resulted from exerted pressure. The
neointima on top of the stent wires measured 56 microns (range, 42-88
microns) after 1 week and 139 microns (range, 84-250 microns) after 4
weeks. CONCLUSIONS. Results from this study show that this radiopaque
endoprosthesis can be safely placed in normal coronary arteries of pigs.
After 4 weeks, all stents were patent and there was no need for additional
antithrombotic treatment, whereas neointimal proliferation was limited.
ARTICLES
Coronary stenting with a new, radiopaque, balloon-expandable endoprosthesis in pigs
Department of Cardiology, Erasmus University Rotterdam, The Netherlands.
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