Circulation, Vol 83, 2021-2028, Copyright © 1991 by American Heart Association
M Tominaga, A Matsumori, I Okada, T Yamada and C Kawai
BACKGROUND. The effects of carteolol, a nonselective beta-adrenergic
receptor blocker with intrinsic sympathomimetic activity, were compared
with those of metoprolol in a murine model of viral myocarditis and dilated
cardiomyopathy caused by encephalomyocarditis virus. METHODS AND RESULTS.
In the acute experiment, BALB/c and DBA/2 mice were inoculated with
encephalomyocarditis virus. BALB/c mice were then given carteolol at 1 (n =
10), 10 (n = 10), 30 (n = 11), or 100 mg/kg (n = 9) daily, and DBA/2 mice
were given carteolol at 1 (n = 9) or 10 mg/kg (n = 9) daily starting the
day of inoculation. Controls were given distilled water (n = 23 for BALB/c
mice and n = 8 for DBA/2 mice). BALB/c mice were killed on day 7, and DBA/2
mice were killed on day 14. In the subacute experiment, DBA/2 mice were
inoculated with the virus and then given carteolol at 1 (n = 12) or 10
mg/kg (n = 16), or distilled water (n = 27) daily, starting on day 14. Mice
were killed on day 28. Virus replication, murine survival, heart weight to
body weight ratio, and histopathological findings were similar in each
group in the acute and subacute experiments. In the chronic experiment,
DBA/2 mice were inoculated with the virus and were then given carteolol at
1 (n = 13) or 10 mg/kg (n = 9), metoprolol at 30 mg/kg (n = 9), or
distilled water (n = 31) daily, starting on day 14. Mice were killed on day
104. Heart weight to body weight ratio and histopathological scores were
significantly lower in mice given carteolol than in the infected control
group. Furthermore, left ventricular cavity dimension, left ventricular
wall thickness, and myocardial fiber diameter of the left ventricle were
significantly reduced in mice given carteolol compared with the control
group. Metoprolol did not cause any significant changes compared with the
control group. CONCLUSIONS. This study suggests that carteolol prevents the
development of myocardial lesions similar to those in dilated
cardiomyopathy after myocarditis in the chronic stage.
ARTICLES
Beta-blocker treatment of dilated cardiomyopathy. Beneficial effect of carteolol in mice
Department of Internal Medicine, Faculty of Medicine, Kyoto University, Japan.
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