Circulation, Vol 84, 160-167, Copyright © 1991 by American Heart Association
SR Srinivasan, GH Dahlen, RA Jarpa, LS Webber and GS Berenson
BACKGROUND. The value of lipoprotein (a) [Lp(a)] in the prediction of
coronary artery disease risk very early in life remains to be established
in different racial groups. METHODS AND RESULTS. Serum Lp(a) distribution
and its relation to parental histories of myocardial infarction were
examined in 2,438 children (8-17 years old) from a biracial community.
Parental myocardial infarction was used as a surrogate measure of future
risk of disease in the offspring. Lp(a) levels averaged 1.7-fold higher in
blacks than in whites (p less than 0.0001). A small but significant sex
difference (females greater than males, p less than 0.05) was seen in both
races. Race was the only independent variable that contributed appreciably
(9%) to the variability of Lp(a) in serum. White children with parental
myocardial infarction (n = 90) had increased levels of Lp(a) compared with
those without parental myocardial infarction (22.4 versus 17.1 mg/dl, p
less than 0.01). Furthermore, among white children, the prevalence of
parental myocardial infarction was higher in those with Lp(a) levels of
more than 25 mg/dl than in those with values of 25 mg/dl or less (9.5%
versus 5.4%, p less than 0.01). In contrast, the relation of Lp(a) to
parental myocardial infarction was not seen in black children. No
associations were observed between parental myocardial infarction and serum
levels of any of the lipids or lipoprotein cholesterol classes in children
of either race. CONCLUSIONS. Serum Lp(a) levels may prove valuable in the
assessment of coronary artery disease risk early in life among white
populations. These findings also emphasize the need to evaluate the
atherogenic potential of Lp(a) in different racial groups.
ARTICLES
Racial (black-white) differences in serum lipoprotein (a) distribution and its relation to parental myocardial infarction in children. Bogalusa Heart Study
Department of Medicine, Louisiana State University Medical Center, New Orleans 70112.
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