Circulation, Vol 84, 2011-2019, Copyright © 1991 by American Heart Association
M Trevisan and M Laurenzi
BACKGROUND. Numerous reports have presented evidence for a positive
association between the maximal velocity of the sodium-lithium
countertransport (Na-Li CT) in erythrocytes and hypertension. The nature of
this association remains to be clarified. METHODS AND RESULTS. This report
presents correlates of Na-Li CT in a population sample of 3,591 people aged
5-74 years. Males had higher mean age- specific levels of Na-Li CT than
females except for the 5-14-year age stratum. In adults aged 25-74, for
both men (n = 1,044) and women (n = 1,192), body mass index, plasma uric
acid and glucose, alcohol consumption, and red blood cell mean corpuscular
volume were positively related to countertransport in multivariate
analyses; plasma high- density lipoprotein (HDL) cholesterol and plasma
potassium were inversely related. Plasma non-HDL cholesterol was
independently and directly related to Na-Li CT in women, and plasma sodium
was inversely associated with Na-Li CT in men. These relations prevailed
for men when persons with hypertension were excluded from the analyses and
prevailed in part for women. When stepwise regression analyses were done
for all men and women combined (n = 2,236), sex ceased to be significantly
related to countertransport with plasma uric acid and alcohol intake in the
model. In adults of either sex, no independent association was detected
between Na-Li CT and age, heart rate, or the ratios of sodium to potassium
or of sodium to creatinine in overnight untimed urine. CONCLUSIONS. In both
sexes, Na-Li CT is significantly and independently associated with a number
of metabolic variables (plasma uric acid, plasma glucose, body mass index,
plasma potassium, and life-style habits [e.g., alcohol intake]). Further
research is needed to elucidate the meaning of the significant associations
between Na-Li CT and the foregoing variables (all of them also related to
blood pressure).
ARTICLES
Correlates of sodium-lithium countertransport. Findings from the Gubbio Epidemiological Study. The Gubbio Collaborative Study Group
Institute of Internal Medicine and Metabolic Diseases, Second Medical School, University of Naples, Italy.
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