Circulation, Vol 85, 205-211, Copyright © 1992 by American Heart Association
D Reed, C Reed, G Stemmermann and T Hayashi
BACKGROUND. The emerging controversy concerning the causal role of
atherosclerosis in the development of aortic aneurysms was examined using
the accumulated clinical and autopsy data obtained during a 20- year
follow-up of a cohort of more than 8,000 men of Japanese ancestry in
Hawaii. METHODS AND RESULTS. Analyses of 174 clinical incident events
indicated that there were two types of aneurysmal disease, 151 aortic
aneurysms and 23 aortic dissections. The baseline risk factors that
predicted the clinical aortic aneurysms were the same factors that
predicted aortic atherosclerosis in the same cohort, namely, high blood
pressure, high serum cholesterol, and cigarette smoking. These same risk
factors were also significantly associated with the occurrence of 27 aortic
aneurysms among 293 autopsied men. The less common aortic dissections had
an age-specific incidence pattern indicative of an innate susceptibility
precipitated by an exposure to another factor. This pattern was consistent
with the findings that the incidence of aortic dissections was predicted
mainly by baseline high blood pressure. CONCLUSIONS. From the perspective
of prevention, it appears that the risk factors for aortic atherosclerosis
and probably atherosclerosis itself are necessary elements in the causal
pathway for the great majority of aortic aneurysms in this cohort.
ARTICLES
Are aortic aneurysms caused by atherosclerosis?
Honolulu Heart Program, HI 96817.
This article has been cited by other articles:
 |
|
 |
|
  S. H. Forsdahl, S. Solberg, K. Singh, and B. K Jacobsen Abdominal aortic aneurysms, or a relatively large diameter of non-aneurysmal aortas, increase total and cardiovascular mortality: the Tromso study Int. J. Epidemiol., November 12, 2009; (2009) dyp320v2. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. Badger, C. V. Soong, I. S. Young, A. McGinty, C. Mercer, and A. E. Hughes The Influence of COX-2 Single Nucleotide Polymorphisms on Abdominal Aortic Aneurysm Development and the Associated Inflammation Angiology, October 1, 2009; 60(5): 576 - 581. [Abstract] [PDF]
|
|
|
|
 |
|
 C. W. Kotze, S. W. Jusuf, L. J. Menezes, B. F. Hutton, P. J. Ell, and A. M. Groves Reply: Vascular Imaging with 18F-FDG PET/CT: Optimal 18F-FDG Circulation Time? J. Nucl. Med., September 1, 2009; 50(9): 1560 - 1561. [Full Text] [PDF]
|
|
|
|
 |
|
 A. Jones, R. Deb, E. Torsney, F. Howe, M. Dunkley, Y. Gnaneswaran, D. Gaze, H. Nasr, I. M. Loftus, M. M. Thompson, et al. Rosiglitazone Reduces the Development and Rupture of Experimental Aortic Aneurysms Circulation, June 23, 2009; 119(24): 3125 - 3132. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. H. Forsdahl, K. Singh, S. Solberg, and B. K. Jacobsen Risk Factors for Abdominal Aortic Aneurysms: A 7-Year Prospective Study: The Tromso Study, 1994-2001 Circulation, April 28, 2009; 119(16): 2202 - 2208. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. H. Lin, T. T. Huynh, P. Kougias, J. Huh, S. A. LeMaire, and J. S. Coselli Descending Thoracic Aortic Dissection: Evaluation and Management in the Era of Endovascular Technology Vascular and Endovascular Surgery, February 1, 2009; 43(1): 5 - 24. [Abstract] [PDF]
|
|
|
|
|
|
S. A. Badger, M. E. O'Donnell, M. A. Sharif, C. McMaster, I. S. Young, and C. V. Soong The Role of Smoking in Abdominal Aortic Aneurysm Development Angiology, February 1, 2009; 60(1): 115 - 119. [Abstract] [PDF]
|
|
|
|
 |
|
 C. A. Nienaber, I. Akin, R. Erbel, and A. Haverich CHAPTER 31 Diseases of the Aorta and Trauma to the Aorta and the Heart ESC Textbook of Cardiovascular Medicine, January 1, 2009; 2(1): med-9780199566990-chapter - med-9780199566990-chapter. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. D. Patel and R. R. Arora Pathophysiology, diagnosis, and management of aortic dissection Therapeutic Advances in Cardiovascular Disease, December 1, 2008; 2(6): 439 - 468. [Abstract] [PDF]
|
|
|
|
|
|
S. A. Badger, M. E. O'Donnell, M. A. Sharif, C. S. Boyd, R. J. Hannon, L. L. Lau, B. Lee, and C. V. Soong Risk Factors for Abdominal Aortic Aneurysm and the Influence of Social Deprivation Angiology, October 1, 2008; 59(5): 559 - 566. [Abstract] [PDF]
|
|
|
|
|
|
M. S. Freiberg, A. M. Arnold, A. B. Newman, M. S. Edwards, K. L. Kraemer, and L. H. Kuller Abdominal Aortic Aneurysms, Increasing Infrarenal Aortic Diameter, and Risk of Total Mortality and Incident Cardiovascular Disease Events: 10-Year Follow-Up Data From the Cardiovascular Health Study Circulation, February 26, 2008; 117(8): 1010 - 1017. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Wang, S. A. LeMaire, L. Chen, Y. H. Shen, Y. Gan, H. Bartsch, S. A. Carter, B. Utama, H. Ou, J. S. Coselli, et al. Increased Collagen Deposition and Elevated Expression of Connective Tissue Growth Factor in Human Thoracic Aortic Dissection Circulation, July 4, 2006; 114(1_suppl): I-200 - I-205. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Shimizu, R. N. Mitchell, and P. Libby Inflammation and Cellular Immune Responses in Abdominal Aortic Aneurysms Arterioscler Thromb Vasc Biol, May 1, 2006; 26(5): 987 - 994. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Momiyama, R. Kato, Z. A. Fayad, N. Tanaka, H. Taniguchi, R. Ohmori, T. Kihara, A. Kameyama, K. Miyazaki, K. Kimura, et al. A Possible Association Between Coronary Plaque Instability and Complex Plaques in Abdominal Aorta Arterioscler Thromb Vasc Biol, April 1, 2006; 26(4): 903 - 909. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Caligiuri, P. Rossignol, P. Julia, E. Groyer, D. Mouradian, D. Urbain, N. Misra, V. Ollivier, M. Sapoval, P. Boutouyrie, et al. Reduced Immunoregulatory CD31+ T Cells in Patients With Atherosclerotic Abdominal Aortic Aneurysm Arterioscler Thromb Vasc Biol, March 1, 2006; 26(3): 618 - 623. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. T. Tsai, C. A. Nienaber, and K. A. Eagle Acute Aortic Syndromes Circulation, December 13, 2005; 112(24): 3802 - 3813. [Full Text] [PDF]
|
|
|
|
 |
|
 A. Yonemura, Y. Momiyama, Z. A. Fayad, M. Ayaori, R. Ohmori, K. Higashi, T. Kihara, S. Sawada, N. Iwamoto, M. Ogura, et al. Effect of lipid-lowering therapy with atorvastatin on atherosclerotic aortic plaques detected by noninvasive magnetic resonance imaging J. Am. Coll. Cardiol., March 1, 2005; 45(5): 733 - 742. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. C. Newby Dual Role of Matrix Metalloproteinases (Matrixins) in Intimal Thickening and Atherosclerotic Plaque Rupture Physiol Rev, January 1, 2005; 85(1): 1 - 31. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. A. Henriques, J. Huang, S. S. D'Souza, A. Daugherty, and L. A. Cassis Orchidectomy, But Not Ovariectomy, Regulates Angiotensin II-Induced Vascular Diseases in Apolipoprotein E-Deficient Mice Endocrinology, August 1, 2004; 145(8): 3866 - 3872. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Saraff, F. Babamusta, L. A. Cassis, and A. Daugherty Aortic Dissection Precedes Formation of Aneurysms and Atherosclerosis in Angiotensin II-Infused, Apolipoprotein E-Deficient Mice Arterioscler Thromb Vasc Biol, September 1, 2003; 23(9): 1621 - 1626. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Nienaber and K. A. Eagle Aortic Dissection: New Frontiers in Diagnosis and Management: Part I: From Etiology to Diagnostic Strategies Circulation, August 5, 2003; 108(5): 628 - 635. [Full Text] [PDF]
|
|
|
|
 |
|
 S. Kakko, T. Raisanen, M. Tamminen, J. Airaksinen, K. Groundstroem, T. Juvonen, A. Ylitalo, P. Uusimaa, and M. J. Savolainen Candidate locus analysis of familial ascending aortic aneurysms and dissections confirms the linkage to the chromosome 5q13-14 in Finnish families J. Thorac. Cardiovasc. Surg., July 1, 2003; 126(1): 106 - 113. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. B. Rodin, M. L. Daviglus, G. C. Wong, K. Liu, D. B. Garside, P. Greenland, and J. Stamler Middle Age Cardiovascular Risk Factors and Abdominal Aortic Aneurysm in Older Age Hypertension, July 1, 2003; 42(1): 61 - 68. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Nomura, A. Ihara, M. Yoshitatsu, K. Tamura, A. Katayama, and K. Ihara Relationship between coagulation cascade, cytokine, adhesion molecule and aortic aneurysm Eur. J. Cardiothorac. Surg., June 1, 2003; 23(6): 1034 - 1039. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. T. Powell and R. M. Greenhalgh Small Abdominal Aortic Aneurysms N. Engl. J. Med., May 8, 2003; 348(19): 1895 - 1901. [Full Text] [PDF]
|
|
|
|
 |
|
 P. McCarron, M. Okasha, J. McEwen, and G. D. Smith Height in Young Adulthood and Risk of Death from Cardiorespiratory Disease: A Prospective Study of Male Former Students of Glasgow University, Scotland Am. J. Epidemiol., April 15, 2002; 155(8): 683 - 687. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Erbel, F. Alfonso, C. Boileau, O. Dirsch, B. Eber, A. Haverich, H. Rakowski, J. Struyven, K. Radegran, U. Sechtem, et al. Diagnosis and management of aortic dissection: Task Force on Aortic Dissection, European Society of Cardiology Eur. Heart J., September 2, 2001; 22(18): 1642 - 1681. [PDF]
|
|
|
|
|
|
J.-B. Michel Contrasting Outcomes of Atheroma Evolution: Intimal Accumulation Versus Medial Destruction Arterioscler Thromb Vasc Biol, September 1, 2001; 21(9): 1389 - 1392. [Full Text] [PDF]
|
|
|
|
|
|
K. Singh, K. H. Bonaa, B. K. Jacobsen, L. Bjork, and S. Solberg Prevalence of and Risk Factors for Abdominal Aortic Aneurysms in a Population-based Study : The Tromso Study Am. J. Epidemiol., August 1, 2001; 154(3): 236 - 244. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. R. Brady, F. G. R. Fowkes, S. G. Thompson, and J. T. Powell Aortic Aneurysm Diameter and Risk of Cardiovascular Mortality Arterioscler Thromb Vasc Biol, July 1, 2001; 21(7): 1203 - 1207. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. de Paiva Magalhaes, S. R. M. Fernandes, V. A. Zanardi, C. A. F. Medeiros, R. Y. Midori, Z. Sachetto, and A. M. Samara Ehlers-Danlos Syndrome Type IV and Multiple Aortic Aneurysms: A Case Report Angiology, March 1, 2001; 52(3): 223 - 228. [Abstract] [PDF]
|
|
|
|
 |
|
 R J. Lewis, A R. Schnatter, A. M Katz, F S Thompson, N. Murray, G. Jorgensen, and G. Thériault Updated mortality among diverse operating segments of a petroleum company Occup. Environ. Med., September 1, 2000; 57(9): 595 - 604. [Abstract] [Full Text]
|
|
|
|
|
|
J. R. Parra, R. A. Cambria, J. A. Freischlag, G. R. Seabrook, and J. B. Towne Smoking Increases Proteolytic Activity in the Human Abdominal Aorta Vascular and Endovascular Surgery, November 1, 1998; 32(6): 617 - 622. [Abstract] [PDF]
|
|
|
|
|
|
M.J. Davies Aortic Aneurysm Formation : Lessons From Human Studies and Experimental Models Circulation, July 21, 1998; 98(3): 193 - 195. [Full Text] [PDF]
|
|
|
|
|
|
T. Freestone, R.J. Turner, D.J. Higman, M.J. Lever, and J.T. Powell Influence of Hypercholesterolemia and Adventitial Inflammation on the Development of Aortic Aneurysm in Rabbits Arterioscler Thromb Vasc Biol, January 1, 1997; 17(1): 10 - 17. [Abstract] [Full Text]
|
|
|
|
 |
|
 G. Simon, D. Nordgren, S. Connelly, and P. J. Shultz Screening for Abdominal Aortic Aneurysms in a Hypertensive Patient Population Arch Intern Med, October 14, 1996; 156(18): 2081 - 2084. [Abstract] [PDF]
|
|
|
|
|
|
H. G. Alcorn, S. K. Wolfson Jr, K. Sutton-Tyrrell, L. H. Kuller, D. O'Leary, and Risk Factors for Abdominal Aortic Aneurysms in Older Adults Enrolled in the Cardiovascular Health Study Arterioscler Thromb Vasc Biol, August 1, 1996; 16(8): 963 - 970. [Abstract] [Full Text]
|
|