Circulation, Vol 85, 46-53, Copyright © 1992 by American Heart Association
FL Anderson, JD Port, BB Reid, P Larrabee, G Hanson and MR Bristow
BACKGROUND. Myocardial adrenergic neurotransmitters and beta-adrenergic
receptor levels were measured in left and right ventricular myocardial
specimens obtained from 30 patients with biventricular failure resulting
from idiopathic dilated cardiomyopathy. METHODS AND RESULTS. Nonfailing
myocardium obtained from 12 organ donors provided control data.
Norepinephrine, dopamine, and neuropeptide Y concentrations were
significantly decreased in failing compared with nonfailing control hearts.
The mean ratio of dopamine to norepinephrine and of dopamine to
neuropeptide Y in failing hearts was also significantly decreased compared
with nonfailing control hearts. Compared with nonfailing control hearts,
Bmax and beta 1-receptor density were significantly decreased in failing
hearts and there were weak but significantly positive correlations of Bmax
and beta 1-adrenergic receptors with norepinephrine, dopamine, and
neuropeptide Y. CONCLUSIONS. Norepinephrine and its cotransmitter
neuropeptide Y are depleted in failing human ventricular myocardium.
Decreased norepinephrine stores correlate weakly with beta 1-adrenergic
receptor downregulation consistent with the hypothesis that norepinephrine
depletion occurs in response to increased adrenergic drive. Decreased
dopamine relative to norepinephrine implies that an abnormality of dopamine
conversion to norepinephrine is not present in failing human heart.
ARTICLES
Myocardial catecholamine and neuropeptide Y depletion in failing ventricles of patients with idiopathic dilated cardiomyopathy. Correlation with beta-adrenergic receptor downregulation
Department of Medicine (Cardiology), University of Utah School of Medicine, Salt Lake City.
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