Circulation, Vol 85, 1374-1379, Copyright © 1992 by American Heart Association
JJ McMurray, SG Ray, I Abdullah, HJ Dargie and JJ Morton
BACKGROUND. Endothelins are recently characterized vasoconstrictor
peptides. As chronic heart failure (CHF) is characterized by peripheral
arteriolar and renal vasoconstriction, we have measured venous plasma
endothelin-like immunoreactivity ("endothelin") in patients with this
syndrome. METHODS AND RESULTS. Compared with age- and sex-matched healthy
volunteers (mean +/- SEM plasma endothelin concentration 6.4 +/- 0.3
pmol/l, n = 16), patients with severe CHF had elevated peripheral venous
endothelin concentrations (12.4 +/- 0.6 pmol/l, n = 47, p less than 0.01).
Plasma endothelin did not increase with exercise in normal subjects or in
patients. Plasma endothelin concentration (mean, 13.4 +/- 0.9 pmol/l) did
not correlate with plasma atrial natriuretic factor concentration (mean,
88.9 +/- 11.9 pg/ml) in patients with CHF (n = 21). There was also no
correlation between plasma endothelin and serum urea or between endothelin
and serum creatinine in patients with CHF (n = 34). There was, however,
significant renal extraction of endothelin (aorta, 11.1 +/- 0.8 pmol/l;
renal vein, 8.8 +/- 0.6 pmol/ml; p = 0.02) in patients with CHF (n = 13).
CONCLUSIONS. Evidence suggests that circulatory endothelin concentrations
in the range 5-40 pmol/l are vasoactive. Consequently, the endothelin
concentrations found in patients with CHF may be of pathophysiological
significance.
ARTICLES
Plasma endothelin in chronic heart failure
Department of Cardiology, Western Infirmary, Glasgow, UK.
This article has been cited by other articles:
 |
|
 |
|
  B. J Epstein Efficacy and Safety of Darusentan: A Novel Endothelin Receptor Antagonist Ann. Pharmacother., July 1, 2008; 42(7): 1060 - 1069. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Otani, F. Otsuka, K. Inagaki, J. Suzuki, T. Miyoshi, Y. Kano, J. Goto, T. Ogura, and H. Makino Aldosterone Breakthrough Caused by Chronic Blockage of Angiotensin II Type 1 Receptors in Human Adrenocortical Cells: Possible Involvement of Bone Morphogenetic Protein-6 Actions Endocrinology, June 1, 2008; 149(6): 2816 - 2825. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. B. Murray, J. D. Gardner, G. L. Brower, and J. S. Janicki Effects of nonselective endothelin-1 receptor antagonism on cardiac mast cell-mediated ventricular remodeling in rats Am J Physiol Heart Circ Physiol, March 1, 2008; 294(3): H1251 - H1257. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. J. V. McMurray, J. R. Teerlink, G. Cotter, R. C. Bourge, J. G. F. Cleland, G. Jondeau, H. Krum, M. Metra, C. M. O'Connor, J. D. Parker, et al. Effects of Tezosentan on Symptoms and Clinical Outcomes in Patients With Acute Heart Failure: The VERITAS Randomized Controlled Trials JAMA, November 7, 2007; 298(17): 2009 - 2019. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. W. Wray, S. K. Nishiyama, A. J. Donato, M. Sander, P. D. Wagner, and R. S. Richardson Endothelin-1-mediated vasoconstriction at rest and during dynamic exercise in healthy humans Am J Physiol Heart Circ Physiol, October 1, 2007; 293(4): H2550 - H2556. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Gujic, A. Houssiere, O. Xhaet, J.-F. Argacha, N. Denewet, A. Noseda, P. Jespers, C. Melot, R. Naeije, and P. van de Borne Does Endothelin Play a Role in Chemoreception During Acute Hypoxia in Normal Men? Chest, May 1, 2007; 131(5): 1467 - 1472. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Merkus, O. Sorop, B. Houweling, F. Boomsma, A. H. van den Meiracker, and D. J. Duncker NO and prostanoids blunt endothelin-mediated coronary vasoconstrictor influence in exercising swine Am J Physiol Heart Circ Physiol, November 1, 2006; 291(5): H2075 - H2081. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. R. Schwarz, S. Rastogi, V. Kapur, N. Sulemanjee, and J. J. Rodriguez Erectile Dysfunction in Heart Failure Patients J. Am. Coll. Cardiol., September 19, 2006; 48(6): 1111 - 1119. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. D. Jackson, K. Barnes, S. Homer-Vanniasinkam, and A. J. Turner Expression and localization of human endothelin-converting enzyme-1 isoforms in symptomatic atherosclerotic disease and saphenous vein. Experimental Biology and Medicine, June 1, 2006; 231(6): 794 - 801. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Vetter, S. G. Shaw, R. P. Brandes, K. MuNter, W. Vetter, and M. Barton Beneficial Cardiovascular Effects of Endothelin ETA Receptor Blockade in Established Long-Term Heart Failure After Myocardial Infarction. Experimental Biology and Medicine, June 1, 2006; 231(6): 857 - 860. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Maeda, S. Jesmin, M. Iemitsu, T. Otsuki, T. Matsuo, K. Ohkawara, Y. Nakata, K. Tanaka, K. Goto, and T. Miyauchi Weight loss reduces plasma endothelin-1 concentration in obese men. Experimental Biology and Medicine, June 1, 2006; 231(6): 1044 - 1047. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Backs, E. Bresch, M. Lutz, A. V. Kristen, and M. Haass Endothelin-1 inhibits the neuronal norepinephrine transporter in hearts of male rats Cardiovasc Res, August 1, 2005; 67(2): 283 - 290. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S J Leslie, J C S Spratt, S P McKee, F E Strachan, D E Newby, D B Northridge, M A Denvir, and D J Webb Direct comparison of selective endothelin A and non-selective endothelin A/B receptor blockade in chronic heart failure Heart, July 1, 2005; 91(7): 914 - 919. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. B. Tanowitz, H. Huang, L. A. Jelicks, M. Chandra, M. L. Loredo, L. M. Weiss, S. M. Factor, V. Shtutin, S. Mukherjee, R. N. Kitsis, et al. Role of Endothelin 1 in the Pathogenesis of Chronic Chagasic Heart Disease Infect. Immun., April 1, 2005; 73(4): 2496 - 2503. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. B. Murray, J. D. Gardner, G. L. Brower, and J. S. Janicki Endothelin-1 mediates cardiac mast cell degranulation, matrix metalloproteinase activation, and myocardial remodeling in rats Am J Physiol Heart Circ Physiol, November 1, 2004; 287(5): H2295 - H2299. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. E Tisdale, M. B Huang, and S. Borzak Risk factors for hypertensive crisis: importance of out-patient blood pressure control Fam. Pract., August 1, 2004; 21(4): 420 - 424. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. G von Lueder, H. Kjekshus, T. Edvardsen, E. Oie, S. Urheim, L. E. Vinge, M. S. Ahmed, O. A Smiseth, and H. Attramadal Mechanisms of elevated plasma endothelin-1 in CHF: congestion increases pulmonary synthesis and secretion of endothelin-1 Cardiovasc Res, July 1, 2004; 63(1): 41 - 50. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Motte, R. van Beneden, J. Mottet, B. Rondelet, M. Mathieu, X. Havaux, P. Lause, C. Clercx, J.-M. Ketelslegers, R. Naeije, et al. Early activation of cardiac and renal endothelin systems in experimental heart failure Am J Physiol Heart Circ Physiol, December 1, 2003; 285(6): H2482 - H2491. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M Tovar and J. G Gums Tezosentan in the Treatment of Acute Heart Failure Ann. Pharmacother., December 1, 2003; 37(12): 1877 - 1883. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D B McKenzie and A J Cowley Drug therapy in chronic heart failure Postgrad. Med. J., November 1, 2003; 79(937): 634 - 642. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Gattenlohner, C. Waller, G. Ertl, B.-D. Bultmann, H.-K. Muller-Hermelink, and A. Marx NCAM(CD56) and RUNX1(AML1) Are Up-Regulated in Human Ischemic Cardiomyopathy and a Rat Model of Chronic Cardiac Ischemia Am. J. Pathol., September 1, 2003; 163(3): 1081 - 1090. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Maeda, T. Tanabe, T. Miyauchi, T. Otsuki, J. Sugawara, M. Iemitsu, S. Kuno, R. Ajisaka, I. Yamaguchi, and M. Matsuda Aerobic exercise training reduces plasma endothelin-1 concentration in older women J Appl Physiol, July 1, 2003; 95(1): 336 - 341. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Godecke, A. Molojavyi, J. Heger, U. Flogel, Z. Ding, C. Jacoby, and J. Schrader Myoglobin Protects the Heart from Inducible Nitric-oxide Synthase (iNOS)-mediated Nitrosative Stress J. Biol. Chem., June 6, 2003; 278(24): 21761 - 21766. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Chu, R. Takahashi, I. Norota, T. Miyamoto, Y. Takeishi, K. Ishii, I. Kubota, and M. Endoh Signal Transduction and Ca2+ Signaling in Contractile Regulation Induced by Crosstalk Between Endothelin-1 and Norepinephrine in Dog Ventricular Myocardium Circ. Res., May 16, 2003; 92(9): 1024 - 1032. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Ogata, M. Takahashi, S. Ueno, K. Takeuchi, T. Okada, H. Mano, S. Ookawara, K. Ozawa, B. C. Berk, U. Ikeda, et al. Antiapoptotic Effect of Endothelin-1 in Rat Cardiomyocytes In Vitro Hypertension, May 1, 2003; 41(5): 1156 - 1163. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. L. Pina, C. S. Apstein, G. J. Balady, R. Belardinelli, B. R. Chaitman, B. D. Duscha, B. J. Fletcher, J. L. Fleg, J. N. Myers, and M. J. Sullivan Exercise and Heart Failure: A Statement From the American Heart Association Committee on Exercise, Rehabilitation, and Prevention Circulation, March 4, 2003; 107(8): 1210 - 1225. [Full Text] [PDF]
|
|
|
|
|
|
E. Kaluski, I. Kobrin, R. Zimlichman, A. Marmor, O. Krakov, O. Milo, A. Frey, S. Kaplan, R. Krakover, A. Caspi, et al. RITZ-5: randomized intravenousTeZosentan (an endothelin-A/B antagonist)for the treatment of pulmonary edema: A prospective, multicenter, double-blind, placebo-controlled study J. Am. Coll. Cardiol., January 15, 2003; 41(2): 204 - 210. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. F. Luscher, F. Enseleit, R. Pacher, V. Mitrovic, M. R. Schulze, R. Willenbrock, R. Dietz, V. Rousson, D. Hurlimann, S. Philipp, et al. Hemodynamic and Neurohumoral Effects of Selective Endothelin A (ETA) Receptor Blockade in Chronic Heart Failure: The Heart Failure ETA Receptor Blockade Trial (HEAT) Circulation, November 19, 2002; 106(21): 2666 - 2672. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J J V McMurray Heart failure in 10 years time: focus on pharmacological treatment Heart, October 1, 2002; 88(90002): ii40 - 46. [Full Text] [PDF]
|
|
|
|
|
|
W. Johnson, A. Nohria, L. Garrett, J. C. Fang, J. Igo, M. Katai, P. Ganz, and M. A. Creager Contribution of endothelin to pulmonary vascular tone under normoxic and hypoxic conditions Am J Physiol Heart Circ Physiol, August 1, 2002; 283(2): H568 - H575. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Matsumoto, H. Aihara, R. Yamauchi-Kohno, Y. Reien, T. Ogura, H. Yabana, Y. Masuda, T. Sato, I. Komuro, and H. Nakaya Long-Term Endothelin A Receptor Blockade Inhibits Electrical Remodeling in Cardiomyopathic Hamsters Circulation, July 30, 2002; 106(5): 613 - 619. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Ceconi, R. Ferrari, T. Bachetti, C. Opasich, M. Volterrani, B. Colombo, G. Parrinello, and A. Corti Chromogranin A in heart failure. A novel neurohumoral factor and a predictor for mortality Eur. Heart J., June 2, 2002; 23(12): 967 - 974. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Johnson, T. Omland, C. Hall, C. Lucas, O. L. Myking, C. Collins, M. Pfeffer, J.-L. Rouleau, and L. W. Stevenson Neurohormonal activation rapidly decreases after intravenous therapy withdiuretics and vasodilators for class IV heart failure J. Am. Coll. Cardiol., May 15, 2002; 39(10): 1623 - 1629. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Alioglu, A. Orem, I. Bulbul, C. Boz, M. Ozmenoglu, and B. Vanizor Evaluation of Plasma Endothelin-1 Levels in Patients with Cerebral Infarction Angiology, January 1, 2002; 53(1): 77 - 82. [Abstract] [PDF]
|
|
|
|
|
|
P.J. Cowburn and J.G.F. Cleland Endothelin antagonists for chronic heart failure: do they have a role? Eur. Heart J., October 1, 2001; 22(19): 1772 - 1784. [PDF]
|
|
|
|
 |
|
 K. Tadano, J. Suzuki, K. Hanada, M. Nakao, R. Nakao, S. Uehara, H. Ohta, T. Miyauchi, and M. Nishikibe Pathophysiological Roles of Endogenous Endothelin-1 in Dogs with Chronic Heart Failure Produced by Rapid Right Ventricular Pacing J. Pharmacol. Exp. Ther., August 1, 2001; 298(2): 729 - 736. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. K. A. Witte, A. L. Clark, and J. G. F. Cleland Chronic heart failure and micronutrients J. Am. Coll. Cardiol., June 1, 2001; 37(7): 1765 - 1774. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. E. Spieker, G. Noll, F. T. Ruschitzka, and T. F. Luscher Endothelin receptor antagonists in congestive heart failure: a new therapeutic principle for the future? J. Am. Coll. Cardiol., May 1, 2001; 37(6): 1493 - 1505. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-P. Cheng, T. Ukai, K. Onishi, N. Ohte, M. Suzuki, Z.-S. Zhang, H.-J. Cheng, H. Tachibana, A. Igawa, and W. C. Little The role of ANG II and endothelin-1 in exercise-induced diastolic dysfunction in heart failure Am J Physiol Heart Circ Physiol, April 1, 2001; 280(4): H1853 - H1860. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. F. Luscher and M. Barton Endothelins and Endothelin Receptor Antagonists : Therapeutic Considerations for a Novel Class of Cardiovascular Drugs Circulation, November 7, 2000; 102(19): 2434 - 2440. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. A. Walker, S. C. Baicu, A. T. Goldberg, C. E. Widener, D. J. Fary, D. K. Almany, A. Ergul, F. A. Crawford Jr, and F. G. Spinale Temporal endothelin dynamics of the myocardial interstitium and systemic circulation in cardiopulmonary bypass J. Thorac. Cardiovasc. Surg., November 1, 2000; 120(5): 864 - 871. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-T. Shen, P. S Buie, J. J Lynch, S. M Krause, and X.-L. Ma Chronic therapy with an ETA/B receptor antagonist in conscious dogs during progression of congestive heart failure: Intracellular Ca2+ regulation and nitric oxide mediated coronary relaxation Cardiovasc Res, November 1, 2000; 48(2): 332 - 345. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Zolk and M. Bohm The role of the cardiac endothelin system in heart failure Nephrol. Dial. Transplant., June 1, 2000; 15(6): 758 - 760. [Full Text] [PDF]
|
|
|
|
|
|
L. E. Spieker, V. Mitrovic, G. Noll, R. Pacher, M. R. Schulze, J.o. Muntwyler, C. Schalcher, W. Kiowski, T. F. Luscher, and on behalf of the ET 003 Investigators Acute hemodynamic and neurohumoral effects of selective ETA receptor blockade in patients with congestive heart failure J. Am. Coll. Cardiol., June 1, 2000; 35(7): 1745 - 1752. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C Berry and A.L Clark Catabolism in chronic heart failure Eur. Heart J., April 1, 2000; 21(7): 521 - 532. [PDF]
|
|
|
|
|
|
H. Kjekshus, O. A. Smiseth, R. Klinge, E. Oie, M. E. Hystad, and H. Attramadal Regulation of ET: pulmonary release of ET contributes to increased plasma ET levels and vasoconstriction in CHF Am J Physiol Heart Circ Physiol, April 1, 2000; 278(4): H1299 - H1310. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. N. Cohn, R. Ferrari, N. Sharpe, and on Behalf of an International Forum on Cardiac Rem Cardiac remodeling--concepts and clinical implications: a consensus paper from an international forum on cardiac remodeling J. Am. Coll. Cardiol., March 1, 2000; 35(3): 569 - 582. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Walker, F. A. Crawford Jr, and F. G. Spinale MYOCYTE CONTRACTILE DYSFUNCTION WITH HYPERTROPHY AND FAILURE: RELEVANCE TO CARDIAC SURGERY J. Thorac. Cardiovasc. Surg., February 1, 2000; 119(2): 388 - 400. [Full Text] [PDF]
|
|
|
|
|
|
P. A. MacCarthy, R. Grocott-Mason, B. D. Prendergast, and A. M. Shah Contrasting Inotropic Effects of Endogenous Endothelin in the Normal and Failing Human Heart : Studies With an Intracoronary ETA Receptor Antagonist Circulation, January 18, 2000; 101(2): 142 - 147. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Becker, B. Merkely, A. Bauer, L. Geller, L. Fazekas, K. D. Freigang, F. Voss, J. C. Senges, W. Kuebler, and W. Schoels Ventricular arrhythmias induced by endothelin-1 or by acute ischemia: a comparative analysis using three-dimensional mapping Cardiovasc Res, January 14, 2000; 45(2): 310 - 320. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. E. Negrao, M. A. Hamilton, G. C. Fonarow, A. Hage, J. D. Moriguchi, and H. R. Middlekauff Impaired endothelium-mediated vasodilation is not the principal cause of vasoconstriction in heart failure Am J Physiol Heart Circ Physiol, January 1, 2000; 278(1): H168 - H174. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Brunner Cardiac endothelin and big endothelin in right-heart hypertrophy due to monocrotaline-induced pulmonary hypertension in rat Cardiovasc Res, October 1, 1999; 44(1): 197 - 206. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Battistelli, M. Billi, G. Manasse, A. Vittoria, F. Roviello, and S. Forconi Behavior of Circulating Endothelin-1 in a Group of Patients with Acute Myocardial Infarction Angiology, August 1, 1999; 50(8): 629 - 638. [Abstract] [PDF]
|
|
|
|
|
|
M. Malmsjo, A. Bergdahl, X.-H. Zhao, X.-Y. Sun, T. Hedner, L. Edvinsson, and D. Erlinge Enhanced acetylcholine and P2Y-receptor stimulated vascular EDHF-dilatation in congestive heart failure Cardiovasc Res, July 1, 1999; 43(1): 200 - 209. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Bajoria, M. Sullivan, and N. M. Fisk Endothelin concentrations in monochorionic twins with severe twin–twin transfusion syndrome Hum. Reprod., June 1, 1999; 14(6): 1614 - 1618. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Zolk, J. Quattek, G. Sitzler, T. Schrader, G. Nickenig, P. Schnabel, K. Shimada, M. Takahashi, and M. Bohm Expression of Endothelin-1, Endothelin-Converting Enzyme, and Endothelin Receptors in Chronic Heart Failure Circulation, April 27, 1999; 99(16): 2118 - 2123. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Pieske, B. Beyermann, V. Breu, B. M. Loffler, K. Schlotthauer, L. S. Maier, S. Schmidt-Schweda, H. Just, and G. Hasenfuss Functional Effects of Endothelin and Regulation of Endothelin Receptors in Isolated Human Nonfailing and Failing Myocardium Circulation, April 13, 1999; 99(14): 1802 - 1809. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Parker, J. J. Thiessen, R. Reilly, J. H. Tong, D. J. Stewart, and A. S. Pandey Human Endothelin-1 Clearance Kinetics Revealed by a Radiotracer Technique J. Pharmacol. Exp. Ther., April 1, 1999; 289(1): 261 - 265. [Abstract] [Full Text]
|
|