Circulation, Vol 85, 1542-1547, Copyright © 1992 by American Heart Association
JY Lam, L Lacoste and MG Bourassa
BACKGROUND. Cilazapril, a converting enzyme inhibitor, has been shown to
significantly decrease the extent of intimal smooth muscle cell
proliferation after arterial injury in a normotensive rat model. METHODS
AND RESULTS. To assess the influence of cilazapril on myofibrotic changes
after balloon injury, control (n = 7) or cilazapril- treated (n = 9) (20
mg/kg b.i.d.) normal 3-month-old pigs underwent dilatation angioplasty of
the right, and deendothelialization of the left common carotid artery.
Carotid arteries isolated at 4 weeks were examined morphometrically with a
computerized digitizer after in situ glutaraldehyde fixation. Both in the
deendothelialized and dilated arteries, the surface area in square
millimeters of the neointima and media were similar in the treated and
control animals; therefore, the ratio of neointima to media was again not
different. The neointimal changes included a combination of proliferative
changes as well as organization of mural thrombus and were equally well
distributed in the two groups of animals. At the time that the animals were
killed, blood pressure (38.2 +/- 2.1 versus 56.8 +/- 4.8 mm Hg, p = 0.003)
and plasma angiotensin converting enzyme activity (5.6 +/- 4.1 versus 182.3
+/- 70.4, p = 0.02) were lower in treated than in control pigs, but aortic
media thrombogenicity (as assessed in an ex vivo perfusion flow chamber)
and serum lipids were not different between groups. CONCLUSIONS. In pigs,
cilazapril did not alter the development of myofibrotic changes after mild
or severe balloon injury despite plasma angiotensin converting enzyme
activity inhibition.
ARTICLES
Cilazapril and early atherosclerotic changes after balloon injury of porcine carotid arteries
Department of Medicine, Montreal Heart Institute, Quebec, Canada.
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