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Circulation, Vol 85, 1799-1807, Copyright © 1992 by American Heart Association
JL Megnien, V Sene, S Jeannin, A Hernigou, MC Plainfosse, I Merli, V Atger, N Moatti, J Levenson and A Simon
BACKGROUND. The prevalence of coronary calcifications and extracoronary
plaques was studied in patients with asymptomatic hypercholesterolemia.
METHODS AND RESULTS. Ultrafast computed tomography for coronary
calcification (presence or absence: calcium score) and echographic
assessment of carotid, aortic, and femoral plaques were performed in 111
hypercholesterolemic men: 65% had coronary calcification, 72% had
extracoronary plaque. The two lesions were associated as: 1) compared with
subjects without coronary calcification, those with calcification had a
higher prevalence of aortic (p less than 0.05) and femoral (p less than
0.01) plaque and of two diseased sites (p less than 0.05); 2) the
prevalence of coronary calcification was higher in the presence than in the
absence of aortic (p less than 0.05) or femoral (p less than 0.01) plaque
and higher in two (p less than 0.01) and three diseased (p less than 0.05)
sites than in no diseased site; 3) the calcium score was higher in the
presence than in the absence of carotid (p less than 0.05), aortic (p less
than 0.05), or femoral (p less than 0.001) plaque, higher in two (p less
than 0.001) and three diseased (p less than 0.05) sites than in no diseased
sites, and higher in two (p less than 0.01) than in one diseased site; and
4) the calcium score correlated with femoral plaque (p less than 0.001).
Overall, the presence of two or three diseased extracoronary sites versus
no or one diseased site showed a power of 78% for predicting coronary
calcification. Coronary calcium score correlated with age (p less than
0.01) and triglycerides (p less than 0.05). CONCLUSIONS. The close relation
between coronary calcium and extracoronary plaques suggests that echography
of extracoronary vessels could aid in the screening of coronary
atherosclerosis in high-risk, asymptomatic individuals.
ARTICLES
Coronary calcification and its relation to extracoronary atherosclerosis in asymptomatic hypercholesterolemic men. The PCV METRA Group
Centre de Medecine Preventive Cardio-vasculaire, INSERM U 28, Paris, France.
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