Circulation, Vol 86, 394-405, Copyright © 1992 by American Heart Association
KH Bonaa and E Arnesen
BACKGROUND. Prospective epidemiological studies indicate that elevated
heart rate may carry increased risk for coronary heart disease. Little is
known about the relation between heart rate and serum lipid and lipoprotein
concentrations in the general population. METHODS AND RESULTS. We assessed
anthropometric and life-style determinants of heart rate and examined the
association between heart rate and serum lipid and lipoprotein
concentrations in a cross-sectional study of 9,719 men and 9,433 women
12-59 years old. Stratified and multivariate analyses were used to detect
possible modification of effect and to control for confounding variables.
Heart rate was positively associated with male sex and smoking, decreased
with body height and physical activity, and showed a U-shaped relation to
body mass index. In both sexes, there was a significant progressive
increase in age-adjusted levels of total cholesterol, non-high density
lipoprotein (HDL) cholesterol, and triglycerides and a decrease in HDL
cholesterol with heart rate. Men with heart rate greater than 89 beats per
minute had 14.5% higher non-HDL cholesterol and 36.3% higher triglyceride
levels than men with heart rate less than 60 beats per minute. The
corresponding differences in women were 12.5% and 22.2%. The associations
remained significant when anthropometric and life-style factors were
controlled for. The slopes relating total and non-HDL cholesterol level to
heart rate were steeper with advancing age. CONCLUSIONS. Increases in heart
rate correlate with higher levels of atherogenic serum lipid fractions in
the general population. Alterations in aortic impedance and/or autonomic
influences may underlie these associations.
ARTICLES
Association between heart rate and atherogenic blood lipid fractions in a population. The Tromso Study
Institute of Community Medicine, University of Tromso, Norway.
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