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Circulation, Vol 86, 1004-1017, Copyright © 1992 by American Heart Association
WG Kuhle, G Porenta, SC Huang, D Buxton, SS Gambhir, H Hansen, ME Phelps and HR Schelbert
BACKGROUND. Regional myocardial blood flow has been quantified using
transaxial positron emission tomographic (PET) imaging and tracer kinetic
modeling. However, the use of transaxial images limits the accuracy of
regional partial volume corrections and the localization of the quantified
regional flow values. The purpose of the present study was to overcome both
problems by calculating regional flows from reoriented short-axis PET
images. METHODS AND RESULTS. Twelve experiments were performed in four
dogs. 13N-ammonia was injected intravenously while microspheres were
administered into the left atrium during baseline, hyperemic, and low-flow
conditions. Serial transaxial frames were acquired with a 15-plane PET
scanner and reoriented into short-axis frames. The arterial input function
and eight regional myocardial tissue activity curves were derived from the
reoriented frames. The arterial input functions were corrected for ammonia
metabolites, and the myocardial tissue curves were corrected for spillover
of activity, partial volume effects, and heterogeneities in the image's
spatial resolution introduced during reorientation. Corrections for
regional partial volume were based on estimates of the regional myocardial
activity thickness derived from reoriented diastolic images of the heart.
The myocardial 13N-ammonia kinetics were described with a two-pool
compartmental model. Values of regional myocardial blood flow by PET
correlated linearly with those by microspheres (slope, 0.94; y intercept,
0.06 ml/min/g; r = 0.93) over a wide range of flows. CONCLUSIONS. Regional
myocardial blood flow can be measured accurately and noninvasively from
serially acquired and reoriented short-axis 13N-ammonia images, thus
overcoming limitations inherent to the use of transaxially acquired images
and permitting a more complete evaluation of regional blood flows
throughout the left ventricular myocardium.
ARTICLES
Quantification of regional myocardial blood flow using 13N-ammonia and reoriented dynamic positron emission tomographic imaging
Department of Radiological Sciences, UCLA School of Medicine, University of California.
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