This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Horner, S. M. Search for Related Content PubMed PubMed Citation Articles by Horner, S. M.

Circulation, Vol 86, 774-779, Copyright © 1992 by American Heart Association

ARTICLES

Efficacy of intravenous magnesium in acute myocardial infarction in reducing arrhythmias and mortality. Meta-analysis of magnesium in acute myocardial infarction

SM Horner
Department of Cardiology, Middlesex Hospital, London, UK.

BACKGROUND. To ascertain the effect of the intravenous administration of magnesium in acute myocardial infarction on the frequency of arrhythmias and mortality, a meta-analysis of randomized controlled trials was performed. METHODS AND RESULTS. The study included 930 patients with acute myocardial infarction admitted to primary referral hospitals. Administration of magnesium in acute myocardial infarction was associated with a 49% reduction in ventricular tachycardia and fibrillation. The incidence of cardiac arrest was reduced by 58%. The frequency of supraventricular tachycardias was also lower. Overall, there was a 54% reduction in mortality. CONCLUSIONS. Intravenous magnesium is a safe and effective method of reducing the frequency of arrhythmias and mortality in acute myocardial infarction.

This article has been cited by other articles:

				S. E. Lehnart, X. H.T. Wehrens, P. J. Laitinen, S. R. Reiken, S.-X. Deng, Z. Cheng, D. W. Landry, K. Kontula, H. Swan, and A. R. Marks Sudden Death in Familial Polymorphic Ventricular Tachycardia Associated With Calcium Release Channel (Ryanodine Receptor) Leak Circulation, June 29, 2004; 109(25): 3208 - 3214. [Abstract] [Full Text] [PDF]

				J. Amighi, S. Sabeti, O. Schlager, W. Mlekusch, M. Exner, W. Lalouschek, R. Ahmadi, E. Minar, and M. Schillinger Low Serum Magnesium Predicts Neurological Events in Patients With Advanced Atherosclerosis Stroke, January 1, 2004; 35(1): 22 - 27. [Abstract] [Full Text] [PDF]

				T B Hassan, C Jagger, and D B Barnett A randomised trial to investigate the efficacy of magnesium sulphate for refractory ventricular fibrillation Emerg. Med. J., January 1, 2002; 19(1): 57 - 62. [Abstract] [Full Text] [PDF]

				I. Sim and M. A Hlatky Growing pains of meta-analysis BMJ, September 21, 1996; 313(7059): 702 - 703. [Full Text]

				W. R. Herzog, M. L. Schlossberg, K. S. MacMurdy, L. R. Edenbaum, M. J. Gerber, R. A. Vogel, and V. L. Serebruany Timing of Magnesium Therapy Affects Experimental Infarct Size Circulation, November 1, 1995; 92(9): 2622 - 2626. [Abstract] [Full Text]

				Magnesium, myocardial infarction, meta-analysis and megatrials DTB, April 1, 1995; 33(4): 25 - 27. [Abstract] [Full Text] [PDF]

				J. Caspi, E. Rudis, I. Bar, T. Safadi, and M. Saute Effects of Magnesium on Myocardial Function After Coronary Artery Bypass Grafting Ann. Thorac. Surg., April 1, 1995; 59(4): 942 - 947. [Abstract] [Full Text]