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Circulation. 1992;86:1475-1484

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Circulation, Vol 86, 1475-1484, Copyright © 1992 by American Heart Association


ARTICLES

A prospective study of nutritional factors and hypertension among US men

A Ascherio, EB Rimm, EL Giovannucci, GA Colditz, B Rosner, WC Willett, F Sacks and MJ Stampfer
Department of Epidemiology, Harvard School of Public Health, Boston, MA.

BACKGROUND. An effect of diet in determining blood pressure is suggested by epidemiological studies, but the role of specific nutrients is still unsettled. METHODS AND RESULTS. The relation of various nutritional factors with hypertension was examined prospectively among 30,681 predominantly white US male health professionals, 40-75 years old, without diagnosed hypertension. During 4 years of follow-up, 1,248 men reported a diagnosis of hypertension. Age, relative weight, and alcohol consumption were the strongest predictors for the development of hypertension. Dietary fiber, potassium, and magnesium were each significantly associated with lower risk of hypertension when considered individually and after adjustment for age, relative weight, alcohol consumption, and energy intake. When these nutrients were considered simultaneously, only dietary fiber had an independent inverse association with hypertension. For men with a fiber intake of < 12 g/day, the relative risk of hypertension was 1.57 (95% confidence interval, 1.20-2.05) compared with an intake of > 24 g/day. Calcium was significantly associated with lower risk of hypertension only in lean men. Dietary fiber, potassium, and magnesium were also inversely related to baseline systolic and diastolic blood pressure and to change in blood pressure during the follow-up among men who did not develop hypertension. Calcium was inversely associated with baseline blood pressure but not with change in blood pressure. No significant associations with hypertension were observed for sodium, total fat, or saturated, transunsaturated, and polyunsaturated fatty acids. Fruit fiber but not vegetable or cereal fiber was inversely associated with incidence of hypertension. CONCLUSIONS. These results support hypotheses that an increased intake of fiber and magnesium may contribute to the prevention of hypertension.


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L. J. Appel, T. J. Moore, E. Obarzanek, W. M. Vollmer, L. P. Svetkey, F. M. Sacks, G. A. Bray, T. M. Vogt, J. A. Cutler, M. M. Windhauser, et al.
A Clinical Trial of the Effects of Dietary Patterns on Blood Pressure
N. Engl. J. Med., April 17, 1997; 336(16): 1117 - 1124.
[Abstract] [Full Text] [PDF]


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HypertensionHome page
D. G. Simons-Morton, S. A. Hunsberger, L. Van Horn, B. A. Barton, A. M. Robson, R. P. McMahon, L. E. Muhonen, P. O. Kwiterovich, N. L. Lasser, S. Y. S. Kimm, et al.
Nutrient Intake and Blood Pressure in the Dietary Intervention Study in Children
Hypertension, April 1, 1997; 29(4): 930 - 936.
[Abstract] [Full Text]


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CirculationHome page
C. J. O'Donnell, P. M. Ridker, R. J. Glynn, K. Berger, U. Ajani, J. E. Manson, and C. H. Hennekens
Hypertension and Borderline Isolated Systolic Hypertension Increase Risks of Cardiovascular Disease and Mortality in Male Physicians
Circulation, March 4, 1997; 95(5): 1132 - 1137.
[Abstract] [Full Text]


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CirculationHome page
G. C. Curhan, W. C. Willett, E. B. Rimm, D. Spiegelman, A. L. Ascherio, and M. J. Stampfer
Birth Weight and Adult Hypertension, Diabetes Mellitus, and Obesity in US Men
Circulation, December 15, 1996; 94(12): 3246 - 3250.
[Abstract] [Full Text]


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HypertensionHome page
F. M. Sacks, L. E. Brown, L. Appel, N. O. Borhani, D. Evans, and P. Whelton
Combinations of Potassium, Calcium, and Magnesium Supplements in Hypertension
Hypertension, December 1, 1995; 26(6): 950 - 956.
[Abstract] [Full Text]


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Arch Fam MedHome page
C. K. Lardinois
Nutritional Factors and Hypertension
Arch Fam Med, August 1, 1995; 4(8): 707 - 713.
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Arch Intern MedHome page
H. B. Simon
Patient-Directed, Nonprescription Approaches to Cardiovascular Disease
Arch Intern Med, October 24, 1994; 154(20): 2283 - 2296.
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ScienceHome page
W. Willett
Diet and health: what should we eat?
Science, April 22, 1994; 264(5158): 532 - 537.
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Arch Intern MedHome page
National High Blood Pressure Education Program Working Group Report on Primary Prevention of Hypertension
Arch Intern Med, January 25, 1993; 153(2): 186 - 208.
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JWatch GeneralHome page
DIETARY FIBER MAY HELP PREVENT HYPERTENSION
Journal Watch (General), November 17, 1992; 1992(1117): 4 - 4.
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