Circulation, Vol 87, 909-920, Copyright © 1993 by American Heart Association
J Zhang, ZX Yu, S Fujita, ML Yamaguchi and VJ Ferrans
BACKGROUND. This study was undertaken to investigate the qualitative and
quantitative changes that interstitial dendritic cells (IDC) of the heart
undergo during the time course of experimental myocardial infarction.
METHODS AND RESULTS. Left coronary arterial ligations were performed in 43
rats that were killed 2, 4, 7, 14, and 21 days after surgery. Thirteen
unoperated and 39 sham-operated rats were used as controls. Frozen sections
were stained with monoclonal antibodies (OX 6 and W3/25) to identify and
count IDC by light microscopy. Immunoelectron microscopy was also used to
identify IDC. The number of IDC per mm2 of tissue section was calculated
for all hearts. In hearts with myocardial infarction, IDC were counted in
three areas: the center of the myocardial infarction, the border zone, and
the noninfarcted left ventricle. In OX 6 antibody-stained preparations, the
number of IDC per mm2 was 82 +/- 10 in the left ventricle of unoperated
rats. Hearts with myocardial infarction showed marked increases in the
numbers of IDC per mm2 in the border zone (796 +/- 79 at 7 days and 528 +/-
98 at 14 days). In the border zone, IDC often were associated with small
clusters of T-helper lymphocytes, which reacted with W3/25 antibody (the
rat homologue of human CD4). The center of the myocardial infarction showed
an increase in IDC only on day 7 (120 +/- 18). By 21 days, IDC in the
border zone were only slightly increased (159 +/- 15). CONCLUSIONS. These
findings suggest that IDC migrate to the myocardial infarction border zone.
They participate in the activation of lymphocytes and in the initiation of
immune responses and decrease in number as inflammation subsides and
scarring develops.
ARTICLES
Interstitial dendritic cells of the rat heart. Quantitative and ultrastructural changes in experimental myocardial infarction
Ultrastructure Section, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md 20892.
This article has been cited by other articles:
 |
|
 |
|
  Y. Mori, T. Izawa, S. Takenaka, M. Kuwamura, and J. Yamate Participation of Functionally Different Macrophage Populations and Monocyte Chemoattractant Protein-1 in Early Stages of Thioacetamide-induced Rat Hepatic Injury Toxicol Pathol, June 1, 2009; 37(4): 463 - 473. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Naito, T. Anzai, Y. Sugano, Y. Maekawa, T. Kohno, T. Yoshikawa, K. Matsuno, and S. Ogawa Differential Effects of GM-CSF and G-CSF on Infiltration of Dendritic Cells during Early Left Ventricular Remodeling after Myocardial Infarction J. Immunol., October 15, 2008; 181(8): 5691 - 5701. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Takahashi, S. Fukushima, K. Yamahara, K. Yashiro, Y. Shintani, S. R. Coppen, H. K. Salem, S. W. Brouilette, M. H. Yacoub, and K. Suzuki Modulated Inflammation by Injection of High-Mobility Group Box 1 Recovers Post-Infarction Chronically Failing Heart Circulation, September 30, 2008; 118(14_suppl_1): S106 - S114. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Yamate, Y. Machida, M. Ide, M. Kuwamura, T. Kotani, O. Sawamoto, and J. LaMarre Cisplatin-Induced Renal Interstitial Fibrosis in Neonatal Rats, Developing as Solitary Nephron Unit Lesions Toxicol Pathol, February 1, 2005; 33(2): 207 - 217. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Yamate, K. Sato, M. Ide, M. Nakanishi, M. Kuwamura, S. Sakuma, and S. Nakatsuji Participation of Different Macrophage Populations and Myofibroblastic Cells in Chronically Developed Renal Interstitial Fibrosis after Cisplatin-induced Renal Injury in Rats Vet. Pathol., May 1, 2002; 39(3): 322 - 333. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. V. Tjurmin, N. M. Ananyeva, E. P. Smith, Y. Gao, M. K. Hong, M. B. Leon, and C. C. Haudenschild Studies on the Histogenesis of Myxomatous Tissue of Human Coronary Lesions Arterioscler. Thromb. Vasc. Biol., January 1, 1999; 19(1): 83 - 97. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Yamate, A. Okado, M. Kuwamura, Y. Tsukamoto, F. Ohashi, Y. Kiso, S. Nakatsuji, T. Kotani, S. Sakuma, and J. Lamarre Immunohistochemical Analysis of Macrophages, Myofibroblasts, and Transforming Growth Factor-{beta} Localization during Rat Renal Interstitial Fibrosis Following Long-Term Unilateral Ureteral Obstruction Toxicol Pathol, November 1, 1998; 26(6): 793 - 801. [Abstract] [PDF]
|
|
|
|
|
|
Jun Zhang, R. J. Wenthold JR., Z.-X. Yu, E. H. Herman, and V. J. Ferrans Characterization of the Pulmonary Lesions Induced in Rats by Human Recombinant Interleukin-2 Toxicol Pathol, November 1, 1995; 23(6): 653 - 666. [Abstract] [PDF]
|
|