Circulation, Vol 87, 921-930, Copyright © 1993 by American Heart Association
M Ruzicka, B Yuan, E Harmsen and FH Leenen
BACKGROUND. The degree of cardiac hypertrophy is not only load dependent:
Among other factors, the renin-angiotensin system may play a role in the
regulation of cardiac myocyte growth. METHODS AND RESULTS. To evaluate the
role of the renin-angiotensin system in volume overload- induced cardiac
hypertrophy, we assessed: 1) the time course of changes in cardiac
hemodynamics, cardiac anatomy, and plasma and cardiac renin activity in
response to volume overload induced by two sizes of abdominal aortocaval
shunt and 2) the effects of chronic treatment with an angiotensin
converting enzyme inhibitor (ACEI) versus an angiotensin II receptor
blocker on hemodynamics and cardiac hypertrophy. Drug treatment started 3
days before shunt surgery. An increase in left ventricular end-diastolic
pressure (LVEDP) and the development of right ventricular (RV) and left
ventricular (LV) eccentric hypertrophy in response to volume overload
occurred within the first week after induction of the shunt. Plasma renin
activity (PRA) and cardiac renin activity peaked shortly after induction of
the shunt. During the chronic phase, LVEDP and PRA decreased somewhat but
remained significantly elevated up to 7 weeks after shunt surgery. Cardiac
renin activity returned toward normal within 4 weeks after surgery.
Treatment with the ACEI enalapril caused only a modest decrease in LV
internal diameter but did not affect increases in LV and RV weights in
response to volume overload despite a major decrease in LVEDP after chronic
treatment. In contrast, treatment with the angiotensin II receptor blocker
losartan, which had similar effects on cardiac and peripheral hemodynamics,
prevented dilation of the LV after 7 days and attenuated the dilation of
the LV after 28 days. Moreover, increases in LV and RV weights were
significantly attenuated by losartan. CONCLUSIONS. The development of
volume overload-induced cardiac hypertrophy is associated with significant
increases in PRA and cardiac renin activity shortly after induction of an
aortocaval shunt. Whereas the two blockers of the renin-angiotensin system
decreased LVEDP to a similar extent, only the angiotensin II receptor
blocker blunted the hypertrophic response of the heart to volume overload,
which is indicative for other than hemodynamic determinants of the cardiac
hypertrophic response. One trophic factor may be cardiac angiotensin II
generated via an angiotensin II-forming enzyme resistant to ACEI and
possibly activated by cardiac volume overload.
ARTICLES
The renin-angiotensin system and volume overload-induced cardiac hypertrophy in rats. Effects of angiotensin converting enzyme inhibitor versus angiotensin II receptor blocker
Hypertension Unit, University of Ottawa Heart Institute, Ontario, Canada.
This article has been cited by other articles:
 |
|
 |
|
  B. Bishara, H. Shiekh, T. Karram, I. Rubinstein, Z. S. Azzam, N. Abu-Saleh, S. Nitecki, J. Winaver, A. Hoffman, and Z. A. Abassi Effects of Novel Vasopressin Receptor Antagonists on Renal Function and Cardiac Hypertrophy in Rats with Experimental Congestive Heart Failure J. Pharmacol. Exp. Ther., August 1, 2008; 326(2): 414 - 422. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Vellaichamy, D. Zhao, N. Somanna, and K. N. Pandey Genetic disruption of guanylyl cyclase/natriuretic peptide receptor-A upregulates ACE and AT1 receptor gene expression and signaling: role in cardiac hypertrophy Physiol Genomics, October 19, 2007; 31(2): 193 - 202. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. M. D. Stefano, L. S. Matsubara, and B. B. Matsubara Myocardial dysfunction with increased ventricular compliance in volume overload hypertrophy Eur J Heart Fail, December 1, 2006; 8(8): 784 - 789. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Winaver, E. Ovcharenko, I. Rubinstein, K. Gurbanov, P. Pollesello, B. Bishara, A. Hoffman, and Z. Abassi Involvement of Rho kinase pathway in the mechanism of renal vasoconstriction and cardiac hypertrophy in rats with experimental heart failure Am J Physiol Heart Circ Physiol, May 1, 2006; 290(5): H2007 - H2014. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. S. Dhalla, M. R. Dent, P. S. Tappia, R. Sethi, J. Barta, and R. K. Goyal Subcellular Remodeling as a Viable Target for the Treatment of Congestive Heart Failure Journal of Cardiovascular Pharmacology and Therapeutics, March 1, 2006; 11(1): 31 - 45. [Abstract] [PDF]
|
|
|
|
|
|
X. Wang, E. Sentex, D. Chapman, and N. S. Dhalla Alterations of adenylyl cyclase and G proteins in aortocaval shunt-induced heart failure Am J Physiol Heart Circ Physiol, July 1, 2004; 287(1): H118 - H125. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Yousufuddin, S. Haji, R. C. Starling, E. M. Tuzcu, N. B. Ratliff, D. J. Cook, A. Abdo, Y. Saad, S. S. Karnik, D. Wang, et al. Cardiac angiotensin II receptors as predictors of transplant coronary artery disease following heart transplantation Eur. Heart J., March 1, 2004; 25(5): 377 - 385. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Schoenmakers, C. Ramakers, J. M. van Opstal, J. D.M. Leunissen, C. Londono, and M. A. Vos Asynchronous development of electrical remodeling and cardiac hypertrophy in the complete AV block dog Cardiovasc Res, August 1, 2003; 59(2): 351 - 359. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Wang, B. Ren, S. Liu, E. Sentex, P. S. Tappia, and N. S. Dhalla Characterization of cardiac hypertrophy and heart failure due to volume overload in the rat J Appl Physiol, February 1, 2003; 94(2): 752 - 763. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Lapointe and J.-L. Rouleau Activation of vascular tissue angiotensin-converting enzyme (ACE) in heart failure: Effects of ACE inhibitors J. Am. Coll. Cardiol., March 6, 2002; 39(5): 776 - 779. [Full Text] [PDF]
|
|
|
|
 |
|
 N. H. Andersen and C. E. Mogensen Review: Inhibition of the renin-angiotensin system, with particular reference to dual blockade treatment Journal of Renin-Angiotensin-Aldosterone System, September 1, 2001; 2(3): 146 - 152. [PDF]
|
|
|
|
 |
|
 G. J. Perry, T. Mori, C.-C. Wei, X. Y. Xu, Y.-F. Chen, S. Oparil, P. Lucchesi, and L. J. Dell'Italia Genetic Variation in Angiotensin-Converting Enzyme Does Not Prevent Development of Cardiac Hypertrophy or Upregulation of Angiotensin II in Response to Aortocaval Fistula Circulation, February 20, 2001; 103(7): 1012 - 1016. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. H. H. Leenen and B. Yuan Mortality After Coronary Artery Occlusion in Different Models of Cardiac Hypertrophy in Rats Hypertension, February 1, 2001; 37(2): 209 - 215. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Di Fusco, S. Hashim, and M. B. Anand-Srivastava Volume overload cardiac hypertrophy exhibits decreased expression of Gsalpha and not of Gialpha in heart Am J Physiol Cell Physiol, October 1, 2000; 279(4): C990 - C998. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Colson, F. Ryckwaert, and P. Coriat Renin Angiotensin System Antagonists and Anesthesia Anesth. Analg., November 1, 1999; 89(5): 1143 - 1143. [Full Text] [PDF]
|
|
|
|
 |
|
 R. Malhotra, J. Sadoshima, F. C. Brosius III, and S. Izumo Mechanical Stretch and Angiotensin II Differentially Upregulate the Renin-Angiotensin System in Cardiac Myocytes In Vitro Circ. Res., July 23, 1999; 85(2): 137 - 146. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Brodsky, K. Gurbanov, Z. Abassi, A. Hoffman, R. R. Ruffolo Jr, G. Z. Feuerstein, and J. Winaver Effects of Eprosartan on Renal Function and Cardiac Hypertrophy in Rats With Experimental Heart Failure Hypertension, October 1, 1998; 32(4): 746 - 752. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Hu, P. Gaudron, H.-J. Anders, F. Weidemann, O. Turschner, M. Nahrendorf, and G. Ertl Chronic effects of early started angiotensin converting enzyme inhibition and angiotensin AT1-receptor subtype blockade in rats with myocardial infarction: role of bradykinin Cardiovasc Res, August 1, 1998; 39(2): 401 - 412. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. D. Everett, T. D. Le Cras, C. Xue, and R. A. Johns eNOS expression is not altered in pulmonary vascular remodeling due to increased pulmonary blood flow Am J Physiol Lung Cell Mol Physiol, June 1, 1998; 274(6): L1058 - L1065. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kyriakidis, F. Triposkiadis, J. Dernellis, A. E. Androulakis, P. Mellas, G. A. Kelepeshis, and J. E. Gialafos Effects of Cardiac Versus Circulatory Angiotensin-Converting Enzyme Inhibition on Left Ventricular Diastolic Function and Coronary Blood Flow in Hypertrophic Obstructive Cardiomyopathy Circulation, April 14, 1998; 97(14): 1342 - 1347. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. N. Muller, W. Fischli, J.-P. Clozel, K. F. Hilgers, J. Bohlender, J. Menard, A. Busjahn, D. Ganten, and F. C. Luft Local Angiotensin II Generation in the Rat Heart : Role of Renin Uptake Circ. Res., January 23, 1998; 82(1): 13 - 20. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Balcells, Q. C. Meng, W. H. Johnson Jr., S. Oparil, and L. J. Dell'Italia Angiotensin II formation from ACE and chymase in human and animal hearts: methods and species considerations Am J Physiol Heart Circ Physiol, October 1, 1997; 273(4): H1769 - H1774. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. O. Weinberg, M. A. Lee, M. Weigner, K. Lindpaintner, S. P. Bishop, C. R. Benedict, K. K. L. Ho, P. S. Douglas, E. Chafizadeh, and B. H. Lorell Angiotensin AT1 Receptor Inhibition : Effects on Hypertrophic Remodeling and ACE Expression in Rats With Pressure-Overload Hypertrophy due to Ascending Aortic Stenosis Circulation, March 18, 1997; 95(6): 1592 - 1600. [Abstract] [Full Text]
|
|
|
|
|
|
A. Wickman, P. Friberg, M. A. Adams, G. L. Matejka, C. Brantsing, G. Guron, and J. Isgaard Induction of Growth Hormone Receptor and Insulin-Like Growth Factor-I mRNA in Aorta and Caval Vein During Hemodynamic Challenge Hypertension, January 1, 1997; 29(1): 123 - 130. [Abstract] [Full Text]
|
|
|
|
|
|
R. M. Touyz, J. Fareh, G. Thibault, and E. L. Schiffrin Intracellular Ca2+ Modulation by Angiotensin II and Endothelin-1 in Cardiomyocytes and Fibroblasts From Hypertrophied Hearts of Spontaneously Hypertensive Rats Hypertension, November 1, 1996; 28(5): 797 - 805. [Abstract] [Full Text]
|
|
|
|
|
|
G. Guron, P. Friberg, A. Wickman, C. Brantsing, B. Gabrielsson, and J. Isgaard Cardiac Insulin-like Growth Factor I and Growth Hormone Receptor Expression in Renal Hypertension Hypertension, March 1, 1996; 27(3): 636 - 642. [Abstract] [Full Text]
|
|
|
|
|
|
J. Fareh, R. M. Touyz, E. L. Schiffrin, and G. Thibault Endothelin-1 and Angiotensin II Receptors in Cells From Rat Hypertrophied Heart : Receptor Regulation and Intracellular Ca2+ Modulation Circ. Res., February 1, 1996; 78(2): 302 - 311. [Abstract] [Full Text]
|
|
|
|
|
|
M. Ruzicka, V. Skarda, and F. H.H. Leenen Effects of ACE Inhibitors on Circulating Versus Cardiac Angiotensin II in Volume OverloadInduced Cardiac Hypertrophy in Rats Circulation, December 15, 1995; 92(12): 3568 - 3573. [Abstract] [Full Text]
|
|
|
|
|
|
A. Calderone, N. Takahashi, N. J. Izzo Jr, C. M. Thaik, and W. S. Colucci Pressure- and Volume-Induced Left Ventricular Hypertrophies Are Associated With Distinct Myocyte Phenotypes and Differential Induction of Peptide Growth Factor mRNAs Circulation, November 1, 1995; 92(9): 2385 - 2390. [Abstract] [Full Text]
|
|
|
|
|
|
N. Iwai, H. Shimoike, and M. Kinoshita Cardiac Renin-Angiotensin System in the Hypertrophied Heart Circulation, November 1, 1995; 92(9): 2690 - 2696. [Abstract] [Full Text]
|
|
|
|
|
|
M. Ruzicka and F. H. H. Leenen Relevance of Blockade of Cardiac and Circulatory Angiotensin-Converting Enzyme for the Prevention of Volume Overload–Induced Cardiac Hypertrophy Circulation, January 1, 1995; 91(1): 16 - 19. [Abstract] [Full Text]
|
|