Circulation, Vol 87, 1130-1134, Copyright © 1993 by American Heart Association
E Linnanmaki, M Leinonen, K Mattila, MS Nieminen, V Valtonen and P Saikku
BACKGROUND. An association of chronic Chlamydia pneumoniae infection to
coronary heart disease has been suggested recently. In a recent study, we
demonstrated circulating immune complexes containing chlamydial
genus-specific lipopolysaccharide in patients with coronary heart disease.
The objective of the present study was to investigate whether C. pneumoniae
species-specific immune complexes are present in chronic coronary heart
disease. METHODS AND RESULTS. The presence of Chlamydia- specific
circulating immune complexes was studied in 46 patients with chronic
coronary heart disease and in control subjects. Chlamydial
lipopolysaccharide-containing immune complexes were detected with the
antigen-specific capture method, and they were present in 41% of patients
and 15% of control subjects (p < 0.01). The presence of C. pneumoniae
antibodies in circulating immune complexes was studied by testing the
specificity of antibodies derived from isolated and dissociated immune
complexes by microimmunofluorescence testing and immunoblotting. The C.
pneumoniae indexes based on the relative amount of immune complex-derived
antibodies and free antibodies were significantly higher among patients
compared with control subjects (median, 1/8 versus 1/16; p < 0.001).
Immune complex bound antibodies showed specificity for 98-kd and 42-kd
proteins of C. pneumoniae. CONCLUSIONS. The results suggest that the
majority of the patients with chronic coronary heart disease have a chronic
C. pneumoniae infection in which chlamydial components have an easy access
to circulation to form immune complexes with preexisting antibodies. These
findings give further evidence for the association of chronic C. pneumoniae
infection with coronary heart disease.
ARTICLES
Chlamydia pneumoniae-specific circulating immune complexes in patients with chronic coronary heart disease
Department of Virology, University of Helsinki, Finland.
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