Circulation, Vol 87, 1806-1815, Copyright © 1993 by American Heart Association
WH Barry and JH Bridge
Calcium homeostasis in cardiac myocytes results from the integrated
function of transsarcolemmal Ca2+ influx and efflux pathways modulated by
membrane potential and from intracellular Ca2+ uptake and release caused
predominantly by SR function. These processes can be importantly altered in
different disease states as well as by pharmacological agents, and the
resulting changes in systolic and diastolic [Ca2+]i can cause clinically
significant alterations in contraction and relaxation of the heart. It may
be anticipated that a rapid increase in our understanding of the
pathophysiology of Ca2+ homeostasis in cardiac myocytes will be forthcoming
as the powerful new tools of molecular and structural biology are used to
investigate the regulation of Ca2+ transport systems.
ARTICLES
Intracellular calcium homeostasis in cardiac myocytes
Division of Cardiology, University of Utah School of Medicine, Salt Lake City.
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