Circulation, Vol 88, 198-207, Copyright © 1993 by American Heart Association
SM Carroll, FC White, DM Roth and CM Bloor
BACKGROUND. Coronary collaterals develop in response to an ischemic
stimulus. However, collateral growth is not sufficient to result in the
complete recovery of coronary reserves. Using a porcine model of gradual
coronary artery occlusion, we investigated the effect of continuous heparin
infusion on coronary collateral development. METHODS AND RESULTS. We placed
ameroid constrictors on the left circumflex coronary artery of 16 minipigs;
the ameroid constrictors completely occluded the left circumflex coronary
artery at 10 +/- 1 days. Half of the animals also were instrumented with
subcutaneously placed osmotic pumps and catheters that delivered heparin
(300 units/h) into the external jugular vein. At 2, 3, and 4 weeks, we
assessed blood flow at rest and during vasodilation using radioactive
microspheres. Our results indicate that the animals receiving heparin
restored resting myocardial blood flow to normal levels at or before 2
weeks; in contrast, we did not see normal resting myocardial blood flow
levels in the untreated-ameroid animals until 3 weeks. Under vasodilated
conditions, untreated-ameroid animals experienced a severe loss of coronary
reserves at 2 weeks. Although this improved with time, these animals still
were significantly underperfused at 4 weeks. In contrast, in the
heparin-treated animals, coronary reserves returned to near- normal levels
between 3 and 4 weeks. In addition, infarct size was significantly smaller
in the heparin-treated animals. CONCLUSIONS. These experiments suggest that
the administration of heparin in the early phases of gradual coronary
occlusion accelerates the rate of return of normal blood flow under resting
conditions, substantially increases the recovery of coronary reserve, and
reduces the risk of infarction.
ARTICLES
Heparin accelerates coronary collateral development in a porcine model of coronary artery occlusion
Department of Pathology, University of California, San Diego, La Jolla.
This article has been cited by other articles:
 |
|
 |
|
  S. B. O'Blenes, S. L. Merklinger, A. Jegatheeswaran, A. Campbell, M. Rabinovitch, I. Rebeyka, and G. Van Arsdell Low Molecular Weight Heparin and Unfractionated Heparin Are Both Effective at Accelerating Pulmonary Vascular Maturation in Neonatal Rabbits Circulation, September 9, 2003; 108(90101): II-161 - 166. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Narasinga Rao, R. N. S. Kumar, D. Anil Kumar, H. M. Mohmoud, S. Chandran, A. K. Dhir, D. K. Saxena, S. P. Azhagappan, V. R. Pillai, C. G. Venkitachalam, et al. Coarctation of the Aorta in Neonates And Young Infants: Surgical Experience Asian Cardiovasc Thorac Ann, December 1, 2002; 10(4): 310 - 313. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Tateno, M. Terai, K. Niwa, T. Jibiki, H. Hamada, K. Yasukawa, T. Honda, S. Oana, and Y. Kohno Alleviation of Myocardial Ischemia After Kawasaki Disease by Heparin and Exercise Therapy Circulation, May 29, 2001; 103(21): 2591 - 2597. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Simovic, J. M. Isner, A. H. Ropper, A. Pieczek, and D. H. Weinberg Improvement in Chronic Ischemic Neuropathy After Intramuscular phVEGF165 Gene Transfer in Patients With Critical Limb Ischemia Arch Neurol, May 1, 2001; 58(5): 761 - 768. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y Zhu, Y Hojo, U Ikeda, K Shimada;, and G F BAXTER Production of hepatocyte growth factor during acute myocardial infarction Heart, April 1, 2000; 83(4): 450 - 455. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. Fujita Heparin and angiogenic therapy Eur. Heart J., February 2, 2000; 21(4): 270 - 274. [PDF]
|
|
|
|
 |
|
 D. Bonnet, J. Patkai, D. Tamisier, J. Kachaner, P. Vouhe, and D. Sidi A new strategy for the surgical treatment of aortic coarctation associated with ventricular septal defect in infants using an absorbable pulmonary artery band J. Am. Coll. Cardiol., September 1, 1999; 34(3): 866 - 870. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Jelly, A. Jelly, M. O. Galal, F. Al Fadley, M. de Moor, and Z. Al Halees Influence of Associated Defects and Type of Surgery in Neonatal Aortic Coarctation Asian Cardiovasc Thorac Ann, June 1, 1999; 7(2): 115 - 120. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. J Lopez, R. J. Laham, A. Stamler, J. D Pearlman, S. Bunting, A. Kaplan, J. P Carrozza, F. W Sellke, and M. Simons VEGF administration in chronic myocardial ischemia in pigs Cardiovasc Res, November 1, 1998; 40(2): 272 - 281. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. A. Seirafi, K. G. Warner, R. L. Geggel, D. D. Payne, and R. J. Cleveland Repair of coarctation of the aorta during infancy minimizes the risk of late hypertension Ann. Thorac. Surg., October 1, 1998; 66(4): 1378 - 1382. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Bombardini, E. Picano, and T. Bombardini The Coronary Angiogenetic Effect of Heparin: Experimental Basis and Clinical Evidence Angiology, November 1, 1997; 48(11): 969 - 976. [Abstract] [PDF]
|
|
|
|
|
|
R. A. Brauner, H. Laks, D. C. Drinkwater Jr, F. Scholl, and S. McCaffery Multiple Left Heart Obstructions (Shone's Anomaly) With Mitral Valve Involvement: Long-Term Surgical Outcome Ann. Thorac. Surg., September 1, 1997; 64(3): 721 - 729. [Abstract] [Full Text]
|
|
|
|
|
|
K. Ono, A. Matsumori, T. Shioi, Y. Furukawa, and S. Sasayama Enhanced Expression of Hepatocyte Growth Factor/c-Met by Myocardial Ischemia and Reperfusion in a Rat Model Circulation, June 3, 1997; 95(11): 2552 - 2558. [Abstract] [Full Text]
|
|
|
|
|
|
S. F. Kaine, E. O'Brian Smith, A. R. Mott, C. E. Mullins, and T. Geva Quantitative Echocardiographic Analysis of the Aortic Arch Predicts Outcome of Balloon Angioplasty of Native Coarctation of the Aorta Circulation, September 1, 1996; 94(5): 1056 - 1062. [Abstract] [Full Text]
|
|
|
|
 |
|
 H. T. Yang, R. W. Ogilvie, and R. L. Terjung Heparin Increases Exercise-Induced Collateral Blood Flow in Rats With Femoral Artery Ligation Circ. Res., March 1, 1995; 76(3): 448 - 456. [Abstract] [Full Text]
|
|